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ORTX

Orchard Therapeutics

$17.00

-0.86 (-4.82%)

07:15
04/25/19
04/25
07:15
04/25/19
07:15

Orchard Therapeutics announces first patient dosed with OTL-103 gene therapy

Orchard Therapeutics announced that the first patient with Wiskott-Aldrich Syndrome, or WAS, has been dosed in a open label study designed to evaluate engraftment of the cryopreserved formulation of OTL-103, its ex vivo autologous hematopoietic stem cell, or HSC, gene therapy. While the registrational trial for OTL-103 for WAS used a fresh cell formulation, Orchard plans to commercialize this and other HSC gene therapies, if approved, using a cryopreserved formulation. In total, nearly 40 patients have been treated with a cryopreserved product across the company's portfolio. The WAS cryopreserved formulation trial will enroll up to six patients, with the number of patients with successful engraftment measured at six months as the primary endpoint. This patient data will be used to supplement the company's in vitro CMC comparability work between the fresh and cryopreserved formulation.

  • 30

    Apr

ORTX Orchard Therapeutics
$17.00

-0.86 (-4.82%)

02/08/19
GSCO
02/08/19
NO CHANGE
Target $21
GSCO
Buy
Goldman says Orchard track record stands out amid disappointments in gene space
Goldman Sachs analyst Graig Suvannavejh noted that February 7 was "a day of disappointment" in the gene therapy and gene editing space, as Solid Biosciences (SLDB) and Sangamo (SGMO) both reported clinical efficacy data that missed investor expectations and "perhaps also raised concerns about the long-term promise of gene-based approaches." Within this context, he pointed out that he believes Orchard Therapeutics (ORTX) has "the most robust clinical experience in gene therapy, with over 150 patients treated across multiple product candidates and indications." The analyst, who expects new clinical data for Orchard candidates OTL-101 and OTL-102 to be presented later this month to re-affirm his confidence, reiterated his Buy rating and $21 price target on Orchard shares.
12/17/18
GSCO
12/17/18
NO CHANGE
GSCO
Goldman starts Argenx at Conviction Buy, upgrades Orchard to Buy
Goldman Sachs analyst Graig Suvannavejh initiated coverage of Argenx (ARGX) with a Buy rating and $154 price target while adding the shares to his firm's Pan-Europe Conviction List. The company has "unique" antibody technology and a "promising" Phase 3 asset in efgartigimod for the treatment of severe autoimmune disorders, Suvannavejh tells investors in a research note. He believes efgartigimod has a "best-in-class profile" and could reach peak global risk-adjusted sales of EUR 1.6B. Further, Argenx has been advancing cusatuzumab, a novel anti-CD70 antibody for potential use in blood cancers, says the analyst. Suvannavejh also upgraded Orchard Therapeutics (ORTX) to Buy from Neutral and raised his price target for the shares to $21 from $18. The analyst projects $1.2B in peak global sales or Orchard's leading programs and sees "limited" clinical risk. With multiple sets of clinical data expected throughout 2019 on three late-stage candidates currently in registrational trials, anticipated news flow in 2019 could position shares of Orchard well for potential appreciation, Suvannavejh writes.
12/17/18
GSCO
12/17/18
UPGRADE
Target $21
GSCO
Buy
Orchard Therapeutics upgraded to Buy from Neutral at Goldman Sachs
Goldman Sachs analyst Graig Suvannavejh upgraded Orchard Therapeutics to Buy citing increased confidence in the company's pipeline. The analyst raised his price target for the shares to $21 from $18.
11/26/18
11/26/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Nvidia (NVDA) initiated with an Outperform at Credit Suisse. 2. Orchard Therapeutics (ORTX) initiated with an Outperform at Wedbush and Cowen, an Overweight at JPMorgan, and a Neutral at Goldman Sachs. 3. Twist Bioscience (TWST) initiated with an Outperform at Cowen and Baird as well as a Neutral at JPMorgan. 4. Axonics (AXNX) initiated with a Buy at BofA/Merrill and SunTrust, an Outperform at Wells Fargo, and an Overweight at Morgan Stanley. 5. Gamida Cell (GMDA) initiated with a Buy at Needham. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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United Technologies

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United Technologies

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TLRY

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APHA

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Bristol-Myers

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CRY

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IAC

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Osiris

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Wolters Kluwer

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AbbVie

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Incyte

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AbbVie

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Incyte

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ArQule

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AMGN

Amgen

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ALXN

Alexion

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AGIO

Agios Pharmaceuticals

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AZN

AstraZeneca

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BLUE

Bluebird Bio

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BMY

Bristol-Myers

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CELG

Celgene

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NVS

Novartis

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NSTG

NanoString

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KPTI

Karyopharm

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JAZZ

Jazz Pharmaceuticals

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GSK

GlaxoSmithKline

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GILD

Gilead

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DSNKY

Daiichi Sankyo

$0.00

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PFE

Pfizer

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PTLA

Portola Pharmaceuticals

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QGEN

Qiagen

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RHHBY

Roche

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RIGL

Rigel Pharmaceuticals

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SNY

Sanofi

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SGEN

Seattle Genetics

$68.67

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STML

Stemline

$14.20

0.12 (0.85%)

VSTM

Verastem

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CNC

Centene

$53.52

-0.26 (-0.48%)

, WCG

WellCare

$287.16

0.145 (0.05%)

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CNC

Centene

$53.52

-0.26 (-0.48%)

WCG

WellCare

$287.16

0.145 (0.05%)

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HMC

Honda

$25.34

-0.405 (-1.57%)

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RH

RH

$111.28

1.42 (1.29%)

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DISH

Dish

$37.54

-0.35 (-0.92%)

, S

Sprint

$7.01

0.2 (2.94%)

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18:08
Periodicals
Dish leads bidding for Sprint, T-Mobile assets, WSJ reports »

Dish Network (DISH) is…

DISH

Dish

$37.54

-0.35 (-0.92%)

S

Sprint

$7.01

0.2 (2.94%)

TMUS

T-Mobile

$74.90

0.44 (0.59%)

CHTR

Charter

$392.20

2.76 (0.71%)

ATUS

Altice USA

$23.82

0.15 (0.63%)

03/08/13
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AAL

American Airlines

$32.69

-0.39 (-1.18%)

17:31
06/14/19
06/14
17:31
06/14/19
17:31
Periodicals
American Air asks court to end 'devastating' work slowdown, Bloomberg says »

American Airlines urged a…

03/08/13
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03/08/13
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03/06/13
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03/06/13
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ROLL

RBC Bearings

$150.43

-3.38 (-2.20%)

17:16
06/14/19
06/14
17:16
06/14/19
17:16
Hot Stocks
RBC Bearings CEO sells over 5,000 common shares »

In a regulatory filing,…

03/08/13
Wedge Partners
03/08/13
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03/06/13
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03/06/13
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FTNW

FTE Networks

$1.25

(0.00%)

17:14
06/14/19
06/14
17:14
06/14/19
17:14
Hot Stocks
FTE Networks granted financial viability exception by NYSE regulation »

FTE Networks announced…

03/08/13
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03/08/13
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03/06/13
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BA

Boeing

$347.19

-1.54 (-0.44%)

17:14
06/14/19
06/14
17:14
06/14/19
17:14
Hot Stocks
Boeing awarded Air Force contract modification, increases ceiling by $6.53B »

Boeing has been awarded a…

03/08/13
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03/06/13
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  • 17

    Jun

  • 09

    Jul

MDR

McDermott

$7.60

-0.12 (-1.55%)

17:11
06/14/19
06/14
17:11
06/14/19
17:11
Hot Stocks
Chatterjee Fund Management reports 5.6% passive stake in McDermott »

In a regulatory filing,…

03/08/13
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03/08/13
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03/06/13
Citigroup
03/06/13
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PZZA

Papa John's

$50.74

0.28 (0.55%)

17:09
06/14/19
06/14
17:09
06/14/19
17:09
Hot Stocks
Papa John's dismisses KPMG as auditors, hires Ernst & Young »

In a regulatory filing,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
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  • 17

    Jun

  • 20

    Jun

  • 20

    Jun

  • 13

    Nov

EPZM

Epizyme

$11.62

-0.36 (-3.01%)

16:55
06/14/19
06/14
16:55
06/14/19
16:55
Conference/Events
Epizyme to hold a conference call »

Conference call to…

03/08/13
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03/08/13
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03/06/13
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  • 21

    Jun

CACI

CACI

$202.80

-1.205 (-0.59%)

16:54
06/14/19
06/14
16:54
06/14/19
16:54
Conference/Events
CACI to hold a conference call »

Management holds a fiscal…

03/08/13
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03/06/13
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03/06/13
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  • 20

    Jun

HCR

Hi-Crush Inc.

$2.84

0.115 (4.22%)

16:53
06/14/19
06/14
16:53
06/14/19
16:53
Syndicate
Hi-Crush Inc files $1B mixed securities shelf »

The company also files to…

03/08/13
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03/06/13
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SHIP

Seanergy Marine

$0.63

-0.0381 (-5.70%)

16:51
06/14/19
06/14
16:51
06/14/19
16:51
Earnings
Seanergy Marine reports Q1 EPS ($3.23), two estimates ($2.85) »

Reports Q1 revenue…

03/08/13
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03/06/13
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03/06/13
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