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SELB

Selecta Biosciences

$2.07

-0.17 (-7.59%)

08:19
06/12/19
06/12
08:19
06/12/19
08:19

Selecta Biosciences presents data from Phase 2 trial of Sel-212

Selecta Biosciences will present full data from the company's Phase 2 study of SEL-212 for the treatment of chronic refractory gout at the 2019 European League Against Rheumatism Annual European Congress of Rheumatology in Madrid, Spain. SEL-212 is a combination product candidate designed to sustain control of serum uric acid levels in patients with chronic refractory gout, potentially reducing harmful tissue urate deposits which when left untreated can lead to debilitating gout flares and joint deformity. SEL-212 consists of pegadricase, our proprietary pegylated uricase, co-administered with ImmTOR, designed to mitigate the formation of anti-drug antibodies. ADAs develop due to unwanted immune responses to biologic medicines, rendering these therapies less potent, which remains an issue across multiple therapeutic modalities and disease states including chronic refractory gout. The data to be presented will show that 66% of evaluable patients, maintained serum uric acid levels of less than6mg/dL after five once-monthly treatments of SEL-212 at doses of 0.1 or 0.15 mg/kg of ImmTOR in combination with 0.2 mg/kg of pegadricase. The sustained reduction of SUA correlated with inhibition of ADA formation. Furthermore, reduced tissue urate burden, low gout flare rates and severity of flares were observed in the Phase 2 clinical trial. Only 35% of patients treated with five doses of 0.1-0.15 mg/kg of ImmTOR experienced gout flares after initiation during the first month of treatment with continued reduction of gout flare rates over months two through five. No additional patients reported flares after the second month. SEL-212 has been generally well tolerated at clinically active doses following repeated administrations in the trial.

  • 14

    Jun

SELB Selecta Biosciences
$2.07

-0.17 (-7.59%)

10/23/18
STFL
10/23/18
NO CHANGE
STFL
Buy
Selecta SEL-212 data 'very competitive to Krystexxa mono/combo therapy, says Stifel
Stifel analyst Derek Archila views Selecta Biosciences (SELB) SEL-212 Phase 2 data in chronic severe gout as positive and thinks it represents a "very competitive" emerging profile relative to the incumbent brand, Horizon Pharma's (HZNP) Krystexxa. The analyst comes away positive with the fact SEL-212's projected response rate remains competitive on a modified intent-to-treat basis, SVP-Rapamycin was tolerable out to five months of dosing, and SEL-212's rate of gout flares was lower than Krystexxa alone and Krystexxa+methotrexate early on. Archila remains positive on the stock and believes SEL-212 could offer an improvement to the current standard of care for chronic severe gout. Further, Archila does not believe shares fully reflect the program's commercial potential and reiterates a Buy rating on Selecta's shares.
01/28/19
NEED
01/28/19
NO CHANGE
Target $12
NEED
Buy
Selecta Biosciences price target lowered to $12 from $28 at Needham
Needham analyst Chad Messer lowered his price target on Selecta Biosciences to $12 to reflect the impact of equity dilution from the company's recent financing and also the longer timeframe for the launch of its SEL-212 product. Longer term, the analyst keeps his Buy rating on Selecta Biosciences based on the potential for SEL-212 to succeed in clinical trials for refractory and tophaceous gout and for its possibility of "bringing additional SVP programs to the clinic."
02/04/19
MZHO
02/04/19
NO CHANGE
Target $4
MZHO
Buy
Selecta Biosciences price target lowered to $4 from $19 at Mizuho
Mizuho analyst Difei Yang lowered her price target for Selecta Biosciences to $4 following the company's "dilutive" capital raise on January 23. Selecta's cash runway is expected to be into Q2 of 2020 and should be sufficient to support the head-to-head phase 2 trial of SEL-212 versus Krystexxa, Yang tells investors in a research note. The analyst continues to see "significant value" in SEL-212 and believes results from the head-to-head trial could be the next key catalyst. However, additional capital is likely needed for the Phase III trials, she adds. Yang keeps a Buy rating on Selecta Biosciences.
03/18/19
ADAM
03/18/19
NO CHANGE
Target $13
ADAM
Buy
Selecta Biosciences price target cut to $13 from $25 at Canaccord
Canaccord analyst John Newman maintained a Buy rating on Selecta Biosciences and cut his price target to $13 from $25, telling investors that he is still "positive" on SEL-212, but is awaiting validating data from the COMPARE trial, which he says would reduce risk and provide a solid superiority to compare SEL-212 with its closest competitor, Krystexxa. Newman notes that the Phase 2 SEL-212 results did not clearly demonstrate the benefit he was expecting due to study design reasons, and is lowering the probabilyt of success to 60% from 80% and lowered his SEL-212 peak estimated U.S. sales to $750M from $1.2B in 2028.

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