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GBT

Global Blood Therapeutics

$57.45

2.58 (4.70%)

05:59
06/14/19
06/14
05:59
06/14/19
05:59

Global Blood Therapeutics Phase 3 HOPE study of voxelotor met primary endpoint

Global Blood Therapeutics announced new results from its Phase 3 HOPE Study of voxelotor in patients ages 12 and older with sickle cell disease, or SCD. The findings from 274 adolescents and adults treated with voxelotor showed the HOPE Study met its primary endpoint of an improvement in hemoglobin greater than 1 g/dL at 24 weeks with voxelotor 1500 mg compared with placebo, with a favorable safety and tolerability profile. In the study, voxelotor provided a rapid, statistically significant and sustained improvement in hemoglobin levels and reduced the incidence of worsening anemia and hemolysis.

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GBT Global Blood Therapeutics
$57.45

2.58 (4.70%)

05/13/19
PIPR
05/13/19
NO CHANGE
PIPR
Piper 'incrementally more bullish' on GlycoMimetics, Global Blood
After speaking to a practicing hematologist and emergency medicine doctor at a leading medical institution, Piper Jaffray analyst Danielle Brill is "incrementally more bullish" on both GlycoMimetics (GLYC) and Global Blood Therapeutics (GBT). The former has pivotal Phase 3 data with rivipansel expected in July and the latter is in the process of submitting a new drug application for voxelotor via the accelerated approval pathway, Brill tells investors in a research note. Further, the analyst says feedback from the expert reaffirmed her neutral outlook for Bluebird Bio's (BLUE) LentiGlobin. The hematologist expects rivipansel to be successful in the Phase 3 trial and anticipates use for most acute sickle cell disease crises requiring provider intervention, according to Brill. Further, she was surprised to hear how enthusiastic the expert was about voxelotor.
05/28/19
PIPR
05/28/19
NO CHANGE
PIPR
Piper more bullish on GlycoMimetics, Global Blood into upcoming catalysts
After surveying 25 sickle cell disease experts, Piper Jaffray analyst Danielle Brill is "incrementally more bullish" on both GlycoMimetics (GLYC) and Global Blood Therapeutics (GBT) into their upcoming catalysts. GlycoMimetics and partner Pfizer (PFE) have pivotal Phase 3 results with rivipansel, their pan-selectin inhibitor, reading out in July, Brill tells investors in a research note. And Global Blood Therapeutics is expected to complete its new drug application submission for voxelotor via the accelerated approval pathway and present full Phase 3 Hope trial data in June, adds the analyst. Following expert feedback, Brill remains confident for a successful Phase 3 outcome with rivipansel. She believes positive data will drive GlycoMimetics shares "meaningfully higher" in July. Further, the majority of the surveyed doctors believe voxelotor's hemolytic anemia benefit is clinically relevant and most expect accelerated approval based on these data, adds the analyst.
05/29/19
GSCO
05/29/19
INITIATION
Target $75
GSCO
Neutral
Global Blood Therapeutics assumed with a Neutral at Goldman Sachs
Goldman Sachs analyst Paul Choi assumed coverage of Global Blood Therapeutics with a Neutral rating and $75 price target. Prior analyst Terence Flynn had a Neutral rating on the shares with a $59 price target. Choi believes the company's lead asset voxelotor could "shift the paradigm" in the treatment of sickle cell disease, but he believes investors should await more more visibility on the clinical and commercial outcomes.
06/03/19
WEDB
06/03/19
NO CHANGE
Target $107
WEDB
Outperform
Global Blood Therapeutics price target raised to $107 from $95 at Wedbush
Wedbush analyst Liana Moussatos raised her price target for Global Blood Therapeutics to $107 from $95 given reduced clinical, regulatory, commercial and manufacturing risk along with sufficient cash for initial U.S. launch, strong IP and upside potential from multiple potentially material catalysts and as more investors appreciate that FDA is not solely focused on VOC as a primary endpoint for SCD. The analyst reiterates an Outperform rating on the shares.

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