Breaking News Instant updates and real-time market news.

APTO

Aptose Biosciences

$2.21

0.04 (1.84%)

07:20
06/14/19
06/14
07:20
06/14/19
07:20

Aptose Biosciences presents new preclinical data for CG-806

Aptose Biosciences announced that new preclinical data for CG-806, its oral, first-in-class pan-FLT3/pan-BTK inhibitor, is being presented in a poster presentation today at the 24th Congress of the European Hematology Association in Amsterdam, the Netherlands. The poster, CG-806, preclinical in vivo efficacy and safety profile as a pan-FLT3 / pan-BTK inhibitor, highlights the in vivo anti-leukemic efficacy of CG-806 and its GLP toxicology and toxicokinetic profile. In a preclinical MV4-11 FLT3-ITD AML xenograft mouse model, CG-806 suppressed leukemia growth at all doses tested throughout the 28-day period of dosing. After dosing was halted, tumors treated with 10 mg/kg and 30 mg/kg resumed growth but responded again when CG-806 dosing was restarted. In the mice treated with 100 mg/kg, 5 of 11 were cured through day 120, and in the 300 mg/kg group, 10 of 11 of the mice were cured. Retreating the "uncured' mice in these two dose groups for an additional 28 days beginning on day 88 led to rapid and robust antitumor response resulting in "cures" in all retreated mice through day 120. In the "re-treated" mice, no drug resistance and no toxicities were observed. GLP 28-day toxicology and TK studies mice and dogs showed no adverse CG-806-related effects on body weight, ophthalmic, respiratory or neurological examinations, clinical pathology organ weight or macroscopic evaluations. No CG-806-related cardiovascular effects were noted in the 28-day GLP toxicology study or in a separate preclinical cardiovascular safety study.

APTO Aptose Biosciences
$2.21

0.04 (1.84%)

03/01/19
RBCM
03/01/19
INITIATION
Target $6
RBCM
Outperform
Aptose Biosciences initiated with an Outperform at RBC Capital
RBC Capital analyst Gregory Renza started Aptose Biosciences with an Outperform rating and $6 price target, stating that he believes key asset CG-806 has a "promising profile and solid pre-clinical data" in targeted oncology.
03/01/19
RBCM
03/01/19
INITIATION
Target $6
RBCM
Outperform
Aptose Biosciences initiated with an Outperform at RBC Capital
RBC Capital analyst Gregory Renza initiated Aptose Biosciences with an Outperform and $6 price target citing the promising profile and solid per-clinical data for key asset CG-806. Renza sees an opportunity as clinical data generated to de-risk and increase appreciation for its prospects in the complex heme/onc treatment paradigm and a driver of share upside.
01/25/19
01/25/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. SS&C (SSNC) initiated with a Buy at Buckingham. 2. Capital Southwest (CSWC) initiated with a Neutral at B. Riley FBR. 3. Natural Gas Services (NGS) initiated with a Buy at Maxim. 4. Aptose Biosciences (APTO) initiated with an Outperform at Oppenheimer. 5. AzurRx BioPharma (AZRX) initiated with a Buy at Roth Capital. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
01/25/19
OPCO
01/25/19
INITIATION
Target $6
OPCO
Outperform
Aptose Biosciences initiated with an Outperform at Oppenheimer
As previously reported, Oppenheimer analyst Matthew Biegler initiated Aptose Biosciences with an Outperform rating and $6 price target, citing the commercial potential of CG-806 in two major hematology/oncology indications. In a research note to investors, Biegler says he believes CG-806 can selectively disable key signaling pathways that cancer cells need without the "safety baggage" usually associated with multi-kinase inhibitors. Biegler says he would be a buyer of Aptose ahead of CG-806's expected 1H19 entry into the clinic.

TODAY'S FREE FLY STORIES

KNX

Knight-Swift

$30.43

0.37 (1.23%)

11:45
06/25/19
06/25
11:45
06/25/19
11:45
Options
Knight Transportation call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 13

    Nov

11:45
06/25/19
06/25
11:45
06/25/19
11:45
General news
Breaking General news story  »

Atlanta Federal Reserve…

AMZN

Amazon.com

$1,890.97

-22.46 (-1.17%)

, MSFT

Microsoft

$134.89

-2.91 (-2.11%)

11:44
06/25/19
06/25
11:44
06/25/19
11:44
On The Fly
Microsoft slips as analyst sees stock 'materially overvalued' as Azure 'not AWS' »

Saying that Microsoft…

AMZN

Amazon.com

$1,890.97

-22.46 (-1.17%)

MSFT

Microsoft

$134.89

-2.91 (-2.11%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 25

    Jun

  • 09

    Jul

  • 10

    Jul

  • 06

    Aug

WPX

WPX Energy

$11.01

-0.02 (-0.18%)

11:35
06/25/19
06/25
11:35
06/25/19
11:35
Options
WPX Energy put volume heavy and directionally bearish »

Bearish flow noted in WPX…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

LEN

Lennar

$51.10

-0.31 (-0.60%)

11:34
06/25/19
06/25
11:34
06/25/19
11:34
Hot Stocks
Lennar remains confident in reaching FY19 home delivery target of 50,000 homes »

Expects margins to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 27

    Jun

  • 28

    Jun

LEN

Lennar

$50.94

-0.47 (-0.91%)

11:33
06/25/19
06/25
11:33
06/25/19
11:33
Earnings
Lennar sees Q3 EPS $1.25-$1.35, consensus $1.52 »

Sees Q3 new orders of…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 27

    Jun

  • 28

    Jun

11:30
06/25/19
06/25
11:30
06/25/19
11:30
General news
Treasury announced a $75 B batch of auctions for Thursday »

Treasury announced a $75…

ACER

Acer Therapeutics

$4.31

-14.86 (-77.52%)

11:25
06/25/19
06/25
11:25
06/25/19
11:25
Downgrade
Acer Therapeutics rating change  »

Acer Therapeutics…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

CLDR

Cloudera

$5.53

0.005 (0.09%)

11:25
06/25/19
06/25
11:25
06/25/19
11:25
Options
Cloudera call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

CODI

Compass Diversified

$19.00

0.345 (1.85%)

11:25
06/25/19
06/25
11:25
06/25/19
11:25
Conference/Events
Compass Diversified to host investor & analyst meeting »

Investor & Analyst…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

UMC

UMC

$2.14

-0.01 (-0.47%)

11:23
06/25/19
06/25
11:23
06/25/19
11:23
Upgrade
UMC rating change  »

UMC upgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Jul

ACER

Acer Therapeutics

$4.30

-14.87 (-77.57%)

11:18
06/25/19
06/25
11:18
06/25/19
11:18
Downgrade
Acer Therapeutics rating change  »

Acer Therapeutics…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

IBKR

Interactive Brokers

$52.52

0.07 (0.13%)

, ETFC

E-Trade

$44.03

-0.54 (-1.21%)

11:17
06/25/19
06/25
11:17
06/25/19
11:17
Conference/Events
Sandler O'Neill financial analyst to hold an analyst/industry conference call »

Financial Analyst Repetto…

IBKR

Interactive Brokers

$52.52

0.07 (0.13%)

ETFC

E-Trade

$44.03

-0.54 (-1.21%)

SCHW

Charles Schwab

$39.09

-0.06 (-0.15%)

AMTD

TD Ameritrade

$47.90

-0.19 (-0.40%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 23

    Jul

  • 06

    Aug

  • 27

    Oct

$NSD

NASDAQ Market Internals

$0.00

(0.00%)

11:17
06/25/19
06/25
11:17
06/25/19
11:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

$NYE

NYSE Market Internals

$0.00

(0.00%)

11:16
06/25/19
06/25
11:16
06/25/19
11:16
Technical Analysis
NYSE market internals summary »

Volume is average for…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

DLTR

Dollar Tree

$110.51

-2.21 (-1.96%)

11:15
06/25/19
06/25
11:15
06/25/19
11:15
Options
Dollar Tree put volume heavy and directionally bearish »

Bearish flow noted in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

PBR

Petrobras

$16.24

-0.34 (-2.05%)

11:05
06/25/19
06/25
11:05
06/25/19
11:05
Options
Petrobras call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 26

    Jun

RDS.B

Royal Dutch Shell

$66.83

0.04 (0.06%)

11:02
06/25/19
06/25
11:02
06/25/19
11:02
Conference/Events
Royal Dutch Shell management to meet with JPMorgan »

Meetings to be held in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 26

    Jun

MSADY

MS&AD Insurance

$0.00

(0.00%)

11:00
06/25/19
06/25
11:00
06/25/19
11:00
Conference/Events
MS&AD Insurance management to meet with JPMorgan »

Meetings to be held in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 26

    Jun

  • 27

    Jun

DNKN

Dunkin' Brands

$79.51

-1.5 (-1.85%)

, GRUB

GrubHub

$75.00

2.95 (4.09%)

11:00
06/25/19
06/25
11:00
06/25/19
11:00
On The Fly
Grubhub upgrade, Brighthouse downgrades among today's top analyst actions »

Check out today's top…

DNKN

Dunkin' Brands

$79.51

-1.5 (-1.85%)

GRUB

GrubHub

$75.00

2.95 (4.09%)

BHF

Brighthouse Financial

$34.28

-3.82 (-10.03%)

MSFT

Microsoft

$135.30

-2.5 (-1.81%)

AMZN

Amazon.com

$1,887.85

-25.58 (-1.34%)

SHAK

Shake Shack

$67.38

0.7 (1.05%)

CMG

Chipotle

$735.05

10.91 (1.51%)

SBUX

Starbucks

$84.19

0.54 (0.65%)

MCD

McDonald's

$204.99

1.07 (0.52%)

YUM

Yum! Brands

$110.44

-0.18 (-0.16%)

WEN

Wendy's

$19.21

0.06 (0.31%)

JACK

Jack in the Box

$81.61

-1.22 (-1.47%)

TIF

Tiffany

$90.50

-1.36 (-1.48%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 25

    Jun

  • 25

    Jun

  • 27

    Jun

  • 09

    Jul

  • 09

    Jul

  • 09

    Jul

  • 10

    Jul

  • 23

    Jul

  • 26

    Jul

  • 06

    Aug

  • 08

    Aug

  • 14

    Aug

  • 14

    Aug

  • 13

    Nov

11:00
06/25/19
06/25
11:00
06/25/19
11:00
General news
The U.S. consumer confidence drop to a 2-year low »

The U.S. consumer…

HR

Healthcare Realty Trust

$32.43

0.23 (0.71%)

10:59
06/25/19
06/25
10:59
06/25/19
10:59
Conference/Events
Healthcare Realty Trust management to meet with JPMorgan »

Meetings to be held in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 26

    Jun

UN

Unilever; also tag UL

$61.77

-0.11 (-0.18%)

, UL

Unilever; also tag UN

$62.81

-0.11 (-0.17%)

10:59
06/25/19
06/25
10:59
06/25/19
10:59
Periodicals
Unilever to close Nevada plant, impacting about 300 jobs, Reuters reports »

Unilever plans to close…

UN

Unilever; also tag UL

$61.77

-0.11 (-0.18%)

UL

Unilever; also tag UN

$62.81

-0.11 (-0.17%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

BCKIF

Babcock

$0.00

(0.00%)

10:57
06/25/19
06/25
10:57
06/25/19
10:57
Conference/Events
Babcock management to meet with JPMorgan »

Meetings to be held in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 26

    Jun

  • 27

    Jun

ALKS

Alkermes

$21.78

0.19 (0.88%)

10:55
06/25/19
06/25
10:55
06/25/19
10:55
Conference/Events
Alkermes management to meet with JPMorgan »

Meetings to be held in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jun

  • 26

    Jun

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.