Entasis Therapeutics announces new results on antimicrobial programs
Entasis Therapeutics Holdings announced multiple presentations of its innovative programs including sulbactam-durlobactam, zoliflodacin and ETX0282CPDP, during the American Society for Microbiology Microbe Conference 2019. Durlobactam has been approved as the international nonproprietary name for ETX2514. During the conference, Ruben Tommasi, PhD, Chief Scientific Officer at Entasis, provided an overview of the Company's pipeline, underscoring the broad antibacterial activity of sulbactam-durlobactam against Acinetobacter through inhibition of Class A, C and D beta-lactamases and the potential utility of zoliflodacin as a novel single-dose oral treatment for gonorrhea. Dr. Tommasi also discussed ETX0282CPDP's potential as a best-in-class oral agent with potent microbiological activity against multi-drug resistant Enterobacteriaceae, and the Company's novel non-beta-lactam PBP inhibitor program designed to address serious Gram-negative infections. John O'Donnell, Senior Director of Drug Metabolism and Pharmacokinetics at Entasis, spoke and provided a poster presentation on pharmacokinetics, pharmacodynamics and dose projections for sulbactam-durlobactam. These results formed the basis of the dosing regimen tested in the Phase 2 and ongoing ATTACK Phase 3 clinical trial. John Mueller, PhD, Chief Development Officer of Entasis, reviewed novel therapies targeting drug-resistant gonorrhea, including Entasis' first-in-class antibiotic zoliflodacin, which represents the only known novel treatment in late-stage development against this pathogen. In addition, multiple poster presentations demonstrated the potent antibacterial activity of sulbactam-durlobactam against recent geographically diverse, multidrug-resistant Acinetobacter isolates, and the potent antibacterial activity of ETX0282CPDP against contemporary multidrug-resistant Enterobacteriaceae isolates.