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ETTX

Entasis Therapeutics

$6.23

0.04 (0.65%)

08:21
06/27/19
06/27
08:21
06/27/19
08:21

Entasis Therapeutics announces new results on antimicrobial programs

Entasis Therapeutics Holdings announced multiple presentations of its innovative programs including sulbactam-durlobactam, zoliflodacin and ETX0282CPDP, during the American Society for Microbiology Microbe Conference 2019. Durlobactam has been approved as the international nonproprietary name for ETX2514. During the conference, Ruben Tommasi, PhD, Chief Scientific Officer at Entasis, provided an overview of the Company's pipeline, underscoring the broad antibacterial activity of sulbactam-durlobactam against Acinetobacter through inhibition of Class A, C and D beta-lactamases and the potential utility of zoliflodacin as a novel single-dose oral treatment for gonorrhea. Dr. Tommasi also discussed ETX0282CPDP's potential as a best-in-class oral agent with potent microbiological activity against multi-drug resistant Enterobacteriaceae, and the Company's novel non-beta-lactam PBP inhibitor program designed to address serious Gram-negative infections. John O'Donnell, Senior Director of Drug Metabolism and Pharmacokinetics at Entasis, spoke and provided a poster presentation on pharmacokinetics, pharmacodynamics and dose projections for sulbactam-durlobactam. These results formed the basis of the dosing regimen tested in the Phase 2 and ongoing ATTACK Phase 3 clinical trial. John Mueller, PhD, Chief Development Officer of Entasis, reviewed novel therapies targeting drug-resistant gonorrhea, including Entasis' first-in-class antibiotic zoliflodacin, which represents the only known novel treatment in late-stage development against this pathogen. In addition, multiple poster presentations demonstrated the potent antibacterial activity of sulbactam-durlobactam against recent geographically diverse, multidrug-resistant Acinetobacter isolates, and the potent antibacterial activity of ETX0282CPDP against contemporary multidrug-resistant Enterobacteriaceae isolates.

ETTX Entasis Therapeutics
$6.23

0.04 (0.65%)

10/22/18
FBCO
10/22/18
INITIATION
Target $18
FBCO
Outperform
Entasis Therapeutics initiated with an Outperform at Credit Suisse
Credit Suisse analyst Martin Auster started Entasis Therapeutics with an Outperform rating and $18 price target. The analyst notes that Entasis has two Phase 3-ready assets, with ETX2514 being the key value driver for the stock. ETX2514 is being developed to address difficult-to-treat Acinetobacter infections, and has shown promising preclinical efficacy, good tissue distribution, and a clean safety profile to date, he contends. Auster is modeling a 45% probability of success to this program, but projects a potential $400M global peak opportunity by 2033 in this setting.
10/24/18
RHCO
10/24/18
INITIATION
Target $20
RHCO
Buy
Entasis Therapeutics initiated with a Buy at SunTrust
SunTrust analyst Edward Nash initiated Entasis Therapeutics with a Buy rating and a price target of $20, saying the company is "uniquely positioned by targeting bacterial infections where few therapeutic options exist" while also "increasing rates of multi-drug resistance". The analyst notes that Entasis' lead antibiotic "has the potential to grab significant market share as the drug will target well-defined patient populations with limited treatment options" given up to 200K of registered Acinetobacter infections in the U.S. and the E.U.
10/24/18
10/24/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Tesla (TSLA) initiated with an Outperform at JMP Securities. 2. Comcast (CMCSA) resumed with a Buy at Deutsche Bank, reinstated with a Buy at Citi, and assumed with a Neutral at Guggenheim. 3. 2U (TWOU) initiated with a Buy at Needham. 4. Corbus Pharmaceuticals (CRBP) initiated with a Buy at B. Riley FBR. 5. Entasis Therapeutics (ETTX) initiated with a Buy at SunTrust. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
11/08/18
FBCO
11/08/18
NO CHANGE
Target $18
FBCO
Outperform
NEJM article on Entasis' Zoli increases awareness, validates novelty, says Credit Suisse
Credit Suisse analyst Martin Auster notes that Entasis Therapeutics' Phase 2 trial produced positive results, per protocol, demonstrating Zoliflodacin's potential impact on the growing antibiotic-resistance epidemic. As characterized by an NEJM editorial, N. gonorrhea can be a devastating infection if untreated, so the emergence of antibiotic-resistant strands is rather troublesome, he contends, adding that the article describes Zoli's single-dose regimen as "promising," owing to the challenges that occur when following up with patients. Auster continues to believe that an oral, single dose alternative to the SoC will add visibility and credibility to the company's novel pipeline. The analyst reiterates an Outperform rating and $18 price target on the shares.

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