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MRKR

Marker Therapeutics

$6.28

-2.4 (-27.65%)

16:46
07/21/19
07/21
16:46
07/21/19
16:46

Marker Therapeutics reports interim results of MultiTAA T Cell Therapy

Marker Therapeutics announced interim data from an ongoing investigator-sponsored clinical trial led by Baylor College of Medicine, evaluating the company's MultiTAA T cell therapy in patients with pancreatic adenocarcinoma. The trial plans to enroll a total of 45 patients with advanced or borderline resectable pancreatic adenocarcinoma in a three-arm trial. Arm A is for patients with unresectable/metastatic disease who are responding to standard first-line chemotherapy. Arm B is for patients with progressive disease or therapy intolerance. Arm C is an exploratory arm for patients with surgically resectable disease. To date, a total of 19 patients have been administered infusions of MultiTAA T cell therapy. Arm A: This arm was designed to evaluate the safety and potential efficacy of using MultiTAA cells as part of first-line treatment for patients with pancreatic cancer. These patients in the chemo-responsive arm have completed or will complete at least three months of standard-of-care chemotherapy - the period during which a response to chemotherapy would typically occur - before receiving up to six administrations of MultiTAA T cells in conjunction with chemotherapy. Overall tumor volume shrinkage was observed in six out of the eight patients with a measurable tumor after administration of MultiTAA cells. One evaluable patient did not have tumor measurements for analysis. Of the 9 evaluable patients, over half have survived to or beyond the historical median overall survival associated with their respective chemotherapy regimens, and 7 of the 9 patients remain alive. In patients responding to therapy, significant expansion of the infused MultiTAA cells was observed, along with broad-based epitope spreading, with significant expansion of endogenous T cells specific for other tumor specific antigens. Arm B: This arm was designed to evaluate the use of MultiTAA cells as a second-line therapy for patients who have failed first-line chemotherapy. The patients in this chemo-refractory arm are either ineligible for chemotherapy or have progressed on chemotherapy and have received or are receiving up to six doses of MultiTAA T cells as a monotherapy. Among the patients who saw clinical disease stabilization, significant expansion of the infused MultiTAA cells was observed, along with broad-based epitope spreading, with significant expansion of endogenous T cells specific for other tumor specific antigens. Arm C: This arm was designed to assess T cell infiltration and expansion. These patients with borderline surgically resectable disease received or will receive a dose of T cells following chemotherapy, radiotherapy or combination prior to surgical resection and up to five additional doses of T cells after surgery. In these patients, MultiTAA T cells were measurable in meaningful numbers as detected by correlative analysis of resected tumor, and significant expansion of the infused MultiTAA cells was observed, along with broad-based epitope spreading, with significant expansion of endogenous T cells specific for other tumor specific antigens. Overall, investigators observed a clinical benefit correlated with the detection of tumor-reactive T cells in patient peripheral blood and within tumor biopsy samples post-infusion. T cells exhibited activity against both targeted antigens as well as non-targeted TAAs including WT-1, AFP, MART-1 and numerous antigens of the MAGE family, indicating induction of antigen/epitope spreading. No infusion-related systemic- or neurotoxicity was observed, and patients continue to be evaluated and enrolled in the trial.

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  • 09

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MRKR Marker Therapeutics
$6.28

-2.4 (-27.65%)

03/29/19
WBBS
03/29/19
UPGRADE
WBBS
Strong Buy
Marker Therapeutics upgraded to Strong Buy from Buy at WBB Securities
05/30/19
ROTH
05/30/19
INITIATION
Target $10
ROTH
Buy
Marker Therapeutics initiated with a Buy at Roth Capital
Roth Capital analyst Tony Butler started Marker Therapeutics with a Buy rating and $10 price target. The analyst finds the stock undervalued at current levels, saying its acute myeloid leukemia opportunity alone in the adjuvant setting could be valued at $10 per share on a "heavily risk-adjusted" net present value basis. Further, pancreatic cancer data expected during the second half of 2019 could expand Marker's MultiTAA opportunity into solid tumors and provide potential upside to current estimates, adds the analyst.
07/03/19
OPCO
07/03/19
INITIATION
Target $15
OPCO
Outperform
Marker Therapeutics initiated with an Outperform at Oppenheimer
Oppenheimer analyst Matthew Biegler initiated Marker Therapeutics with an Outperform rating and $15 price target.
07/03/19
07/03/19
INITIATION
Target $15

Outperform
Oppenheimer bullish on Marker Therapeutics, initiates with an Outperform
As previously reported, Oppenheimer analyst Matthew Biegler initiated Marker Therapeutics with an Outperform rating and a $15 price target. The analyst sees the Phase 2 trial in AML supporting a streamlined path to market, while multiple readouts from ongoing academic-sponsored trials could de-risk MultiTAA in additional indications.

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