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ACIU

AC Immune

$5.53

0.13 (2.41%)

07:23
08/12/19
08/12
07:23
08/12/19
07:23

AC Immune announces research collaboration with University of Pennsylvania

AC Immune announced a research partnership with leading scientists in the Perelman School of Medicine at the University of Pennsylvania focused on studying the pathological mechanisms of TDP-43 misfolding and aggregation. TDP-43, the transactive response DNA binding protein, is a transcription factor found in most human tissues. It is a recently identified target of growing interest for neuroOrphan indications such as frontotemporal lobar degeneration and amyotrophic lateral sclerosis. It also plays an important role in other significant neurodegenerative indications such as Alzheimer's disease. The collaboration is aimed at deciphering the governing principles of how pathological forms of TDP-43 spread from neuron to neuron, leading to a better understanding of the TDP-43 pathologies in order to support the Company's mission to develop novel therapeutic and diagnostic approaches against FTLD and other neurodegenerative diseases. AC Immune will contribute a two-year research grant to the laboratory of Dr. John Trojanowski and Dr. Virginia M.-Y. Lee. Dr. Trojanowski's research focuses on neurodegeneration and has led to the novel view that major disease-related proteins including Tau, alpha-synuclein and TDP-43, are co-deposited in most neurodegenerative diseases and how these copathologies impact the clinical representation of these diseases. Dr. Lee is a world-renowned leader in research on Tau, alpha-synuclein and the Abeta precursor protein, studying their pathobiological roles in neurodegenerative diseases.

ACIU AC Immune
$5.53

0.13 (2.41%)

11/13/18
LEER
11/13/18
INITIATION
Target $18
LEER
Outperform
AC Immune initiated with an Outperform at Leerink
Leerink analyst Marc Goodman started AC Immune with an Outperform and $18 price target as he initiates Neuroscience space with a Positive View. The analyst believes the Neuroscience sector is experiencing a "renaissance" as multiple new agents and mechanisms are coming up the pipeline across major therapeutic areas, the number of clinical studies is growing nicely, and the FDA is friendly to innovation in this space, companies are getting smarter about speed-to-market strategies and selecting niche sub-populations to focus on for initial product approvals, payer pushback on usage is much lower than in other categories, and physicians are enthusiastic about new agents. Regarding AC Immune, Goodman notes that it has a diversified pipeline of drug candidates and diagnostics for Alzheimer's disease led by a late stage antibody with crenezumab, and has strong partners with Roche (RHHBY) for crenezumab, Johnson & Johnson (JNJ) for Anti-Tau vaccine, Biogen (BIIB) for alphasynuclein-PET tracer diagnostic, and Piramal for TauPET tracer diagnostic.
01/04/19
UBSW
01/04/19
INITIATION
Target $16
UBSW
Buy
AC Immune initiated with a Buy at UBS
UBS analyst Carter Gould initiated AC Immune with a Buy rating and $16 price target.
02/01/19
UBSW
02/01/19
DOWNGRADE
Target $4
UBSW
Neutral
AC Immune downgraded to Neutral from Buy at UBS
UBS analyst Carter Gould downgraded AC Immune to Neutral and cut his price target for the shares to $4 from $6. The analyst says "life after crenezumab is a waiting game until tau."
02/04/19
HCWC
02/04/19
NO CHANGE
Target $8
HCWC
Buy
AC Immune price target lowered to $8 from $18 at H.C. Wainwright
H.C. Wainwright analyst Andrew Fein lowered his price target for AC Immune to $8 to reflect the discontinuation of crenezumab in the valuation. However, despite this setback, the analyst still believes that the fundamental approach of AC Immune is "de-risking in itself" with multiple targets in multiple modalities. The company possesses one of the deepest pipelines in the neurodegenerative space, Fein tells investors in a research note. He reiterates a Buy rating on the shares.

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