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ESPR

Esperion

$35.95

-0.8 (-2.18%)

07:42
08/29/19
08/29
07:42
08/29/19
07:42

Esperion announces results from Phase 2 study of bempedoic acid/ezetimibe combo

Esperion announced positive top-line results from the Phase 2 bempedoic acid / ezetimibe combination tablet study. This was a randomized, double-blind, parallel group study assessing the efficacy and safety of the bempedoic acid / ezetimibe combination tablet compared to ezetimibe and placebo in 179 patients with both hypercholesterolemia and type 2 diabetes. Patients enrolled were on stable background diabetes medications and washed out of lipid modifying therapies. The 12-week study met its primary endpoints as well as key secondary endpoints, including that the bempedoic acid / ezetimibe combination tablet: Significantly lowered LDL-C by 40 percent compared to placebo; Reduced high-sensitivity C-reactive protein, an important marker of inflammation associated with cardiovascular disease, by 25 percent; No worsening of glycemic control; Overall adverse events comparable to placebo; Had no increase in muscle-related AEs, serious adverse events, discontinuations due to AEs or elevations in liver function tests; Achieved LDL-C levels of less than70 mg/dl and an LDL-C reduction of greater than50 percent in approximately 40 percent of patients. The results showed no clinical differences between the bempedoic acid / ezetimibe combination tablet, placebo, and ezetimibe patient groups in the occurrence of: Adverse events with 43 percent, 37 percent, and 30 percent, respectively; Serious adverse events with 0 percent, 2 percent, and 2 percent, respectively; Discontinuations due to AEs with 0 percent, 0 percent, and 2 percent, respectively; No elevations in liver function tests were observed.

ESPR Esperion
$35.95

-0.8 (-2.18%)

05/06/19
BOFA
05/06/19
UPGRADE
BOFA
Neutral
Esperion upgraded to Neutral from Underperform at BofA/Merrill
05/29/19
GSCO
05/29/19
DOWNGRADE
Target $50
GSCO
Sell
Esperion downgraded to Sell from Neutral at Goldman Sachs
Goldman Sachs analyst Paul Choi downgraded Esperion Therapeutics to Sell from Neutral with an unchanged price target of $50. With the regulatory path for bempedoic acid "looking clear," the analyst downgrades the shares on valuation following the recent outperformance. He sees the launch in 2020 as the next driver of the stock.
06/27/19
JEFF
06/27/19
NO CHANGE
Target $85
JEFF
Buy
Esperion funding agreement brings flexibility into 2020, says Jefferies
Esperion's debt financing brings in an immediate $125M, lifting the company's total pro-forma cash to $355M, and gives it flexibility going into 2020, Jefferies analyst Michael Yee tells investors in a research note. The analyst views the deal as a non-dilutive, "fundamentally good access to cash," that helps shore up Esperion's balance sheet "in case of uncertainty and macro risk in 2020." He keeps a Buy rating on the shares with an $85 price target.
06/27/19
JMPS
06/27/19
NO CHANGE
Target $153
JMPS
Outperform
Esperion funding deal with Oberland a positive, says JMP Securities
JMP Securities analyst Jason Butler said he views Esperion's funding transaction with Oberland Capital Management as a positive step for the company that provides it with optionality to optimize investment into bempedoic acid's commercial launch. The capped revenue-based funding agreement provides substantial immediate capital and strengthens the company's resources, said Butler, who maintains an Outperform rating and $153 price target on Esperion shares.

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