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MGNX

MacroGenics

$14.34

-0.15 (-1.04%)

, ZLAB

Zai Lab

$32.56

0.64 (2.01%)

07:54
09/03/19
09/03
07:54
09/03/19
07:54

MacroGenics, Zai Lab to initiate registrational trial of margetuximab in 2019

In January 2019, MacroGenics (MGNX) presented updated clinical data from a combination study of margetuximab plus pembrolizumab in gastric cancer at the 2019 ASCO Gastrointestinal Cancers Symposium. Based on these positive data, MacroGenics and Zai Lab (ZLAB) plan to initiate a global registrational clinical trial of margetuximab in combination with checkpoint inhibitor molecules, including INCMGA0012 and MGD013 in first line patients with HER2-positive gastric or gastroesophageal junction cancer in 2019.

MGNX

MacroGenics

$14.34

-0.15 (-1.04%)

ZLAB

Zai Lab

$32.56

0.64 (2.01%)

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MGNX MacroGenics
$14.34

-0.15 (-1.04%)

05/16/19
FBCO
05/16/19
NO CHANGE
Target $29
FBCO
Outperform
MacroGenics SOPHIA abstract leaves more questions than answers, says Credit Suisse
Commenting on MacroGenics' Phase 3 SOPHIA trial, Credit Suisse analyst Michael Morabito says that physician experts with whom he has been consulting were hoping for a benefit of at least 2 months compared to Herceptin, which they would consider practice changing in this third-line setting of patients who progressed on Herceptin/Perjeta/Kadcyla. With the net benefit for margetuximab coming in at only 0.9 months, the analyst would expect the shares could see increased pressure on this data. He reiterates an Outperform rating and $29 price target on the shares.
06/04/19
STFL
06/04/19
NO CHANGE
STFL
Stifel 'gut reaction' to margetuximab data aligns with 19% selloff
Stifel analyst Stephen Willey says his "gut reaction" to today's more-detailed Sophia data appears to align with how the stock is trading post this morning's presentation. Shares of MacroGenics are down 19%, or $3.55, to $15.17 in midday trading. The analyst found the overall survival data of margetuximab the most disappointing. He had hoped the large absolute median OS benefit in low-affinity CD16A-158 patients favoring margetuximab would offset some of the concern around the clinical relevance of the progression free survival benefit. Unfortunately, however, this benefit appears to be less compelling when viewed in the context of the full Kaplan-Meier curve, Willey tells investors in a research note titled "First Take on SOPHIA Data Presentation - Don't Expect OS to Pick Up the PFS Slack." The analyst continues to believe the Sophia data represents an approvable data set, but he admits the addressable market opportunity is "likely now amplified following today's presentation." The continued perception of margetuximab as an overhang could serve to keep near-term enthusiasm in MacroGenics shares "muted," says Willey. He keeps a Buy rating on the shares.
06/05/19
STFL
06/05/19
NO CHANGE
Target $29
STFL
Buy
MacroGenics price target lowered to $29 from $36 at Stifel
Stephen analyst Kevin Willey lowered his price target for MacroGenics to $29 from $36, saying he expects maturing overall survival data from Sophia to command "meaningful" regulatory and commercial importance given what is likely to remain perceived to be a progression free survival benefit of uncertain clinical relevance. Willey tells investors in a research note that he is now less optimistic directionally-supportive OS data will manifest over time in the intent-to-treat patient population and has "minimal" confidence the early numerical OS separation favoring margetuximab in CD16A-158F patients will prove durable. He maintains a Buy rating.
07/18/19
HCWC
07/18/19
NO CHANGE
Target $39
HCWC
Buy
H.C. Wainwright sees 'nothing sinister' with MacroGenics regaining drug rights
H.C. Wainwright analyst Debjit Chattopadhyay sees nothing "inherently sinister" with flotetuzumab after MacroGenics regained the full rights to the drug. After speaking with management, the analyst says that ex-partner Servier was not been particularly engaged during the development process and that to date, MacroGenics has been funding both the U.S. and European studies. Further, flotetuzumab's emerging clinical profile remains consistent with what was presented at ASH 2018, and an updated presentation on the fully enrolled dose expansion cohort is expected at ASH 2019, Chattopadhyay tells investors in a research note. He keeps a Buy rating on MacroGenics shares with a $39 price target.
ZLAB Zai Lab
$32.56

0.64 (2.01%)

02/07/19
SBSH
02/07/19
UPGRADE
SBSH
Buy
Citi double upgrades MacroGenics to Buy from Sell even after 130% stock rally
Citi analyst Yigal Nochomovitz double upgraded MacroGenics (MGNX) to Buy from Sell and raised his price target for the shares to $39 from $10. The stock closed yesterday up 130%, or $14.49, to $25.60. Following yesterday's data, the analyst raised his probability of success estimate to 70% from 50% for enoblituzumab in head and neck squamous cell carcinoma and non-small cell lung cancer. Additional Phase 1 readouts in 2019 should provide further stock momentum for MacroGenics, Nochomovitz tells investors in a research note. The analyst also sees MacroGenics as positive for Zai Lab (ZLAB). The Sophia data go a long way to validate Zai's choice of partner in MacroGenics, says the analyst.
07/05/19
MACQ
07/05/19
INITIATION
MACQ
Outperform
Zai Lab initiated with an Outperform at Macquarie
07/12/19
BOFA
07/12/19
INITIATION
Target $43
BOFA
Buy
Zai Lab initiated with a Buy at BofA/Merrill
BofA Merrill Lynch analyst Yang Huang initiated Zai Lab with a Buy rating and $43 price target, citing what he views as its strong pipeline of "potential blockbusters" and its emerging in-house discovery abilities.
08/27/19
08/27/19
NO CHANGE

Zai Lab management to meet with SVB Leerink
Meetings to be held in Boston on August 26-30 hosted by SVB Leerink.

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BGNE

BeiGene

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2.61 (1.96%)

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CE

Celanese

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Boeing

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AA

Alcoa

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CMC

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Downgrade
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CMC

Commercial Metals

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Sony

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Disney

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Viacom

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Viacom

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Vivendi

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Sony

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Patterson-UTI

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ESE

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CoStar Group

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CNNE

Cannae Holdings

$28.05

0.875 (3.22%)

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Exagen

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Datadog

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PING

Ping Identity

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IGMS

IGM Biosciences

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Envista

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PTON

Peloton

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Endeavor

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Oportun Financial

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WE

We Company

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CSCO

Cisco

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SoftBank

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SoftBank

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PG

Procter & Gamble

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0.37 (0.30%)

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Coca-Cola

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08:17
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Periodicals
Kellogg, Coca-Cola among staples stocks for dividends, Barron's says »

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PG

Procter & Gamble

$122.22

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KO

Coca-Cola

$53.90

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PEP

PepsiCo

$134.49

-0.98 (-0.72%)

CL

Colgate-Palmolive

$70.97

0.01 (0.01%)

KMB

Kimberly-Clark

$135.13

0.9 (0.67%)

K

Kellogg

$63.79

0.07 (0.11%)

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CMCSA

Comcast

$46.36

-0.32 (-0.69%)

, CMCSK

Comcast

$0.00

(0.00%)

08:09
09/21/19
09/21
08:09
09/21/19
08:09
Periodicals
Facebook, Microsoft among growth stocks for risky times, Barron's says »

Comcast (CMCSA), Delta…

CMCSA

Comcast

$46.36

-0.32 (-0.69%)

CMCSK

Comcast

$0.00

(0.00%)

DAL

Delta Air Lines

$58.63

-0.05 (-0.09%)

FANG

Diamondback Energy

$96.90

-0.45 (-0.46%)

EHC

Encompass Health

$64.41

-0.01 (-0.02%)

FB

Facebook

$189.88

-0.27 (-0.14%)

JNJ

Johnson & Johnson

$131.73

1.75 (1.35%)

MSFT

Microsoft

$139.34

-1.74 (-1.23%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

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