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GNPX

Genprex

$0.88

-0.0065 (-0.73%)

08:14
09/11/19
09/11
08:14
09/11/19
08:14

Genprex announces study that shows TUSC2 prevented tumor growth in TNBC

Genprex announced that independent researchers reported in a recent study that TUSC2, a tumor suppressor gene and the active agent in Genprex's Oncoprex immunogene therapy, prevented tumor growth in triple-negative breast cancer, or TNBC, which is currently considered an incurable cancer with limited therapeutic options. Genprex has no affiliation with these researchers. The study, published in Nature, first found MicroRNA-138 as a diagnostic biomarker for TNBC, which currently lacks targeted therapies due to its inability to express the estrogen and progesterone hormone receptors and the human epidermal growth factor receptor 2, or HER2, thus the name for triple-negative breast cancer. Depletion of miR-138 was found to lead to apoptotic cell death in vitro and prevented tumorigenesis in vivo. TUSC2 was found to be a direct target of miR-138, and TUSC2 mimics the effects of miR-138 knockdown, preventing tumor growth. The researchers deduced that TUSC2 is a downstream tumor suppressor that is directly repressed by miR-138. The study reports that triple-negative breast cancer is an extremely aggressive subtype of breast cancer which is associated with poor prognosis and high mortality rates. The lack of targeted treatment for triple-negative breast cancer makes it an increasingly feared diagnosis. Genprex is conducting clinical and pre-clinical research to evaluate the effectiveness of TUSC2 when combined with targeted therapies and immunotherapies for non-small cell lung cancer. Existing pre-clinical data also suggest that TUSC2 may be effective against glioblastoma, head and neck cancer, kidney cancer and soft tissue sarcomas. Now, this new independent study raises the possibility that TUSC2 expression, through miR-138 targeting, may also be used to treat the most aggressive subset of breast cancer.

GNPX Genprex
$0.88

-0.0065 (-0.73%)

09/14/18
MAXM
09/14/18
INITIATION
MAXM
Buy
Genprex initiated with a Buy at Maxim
09/14/18
MAXM
09/14/18
INITIATION
Target $5
MAXM
Buy
Genprex initiated with a Buy at Maxim
Maxin analyst Caroline Palomeque initiated Genprex with a Buy rating and a price target of $5. The analyst cites the potential of the company's lead therapeutic candidate Oncoprex in treating non-small cell lung cancer, with preclinical studies suggesting that the drug may "sensitize cancer cells to other targeted therapies and improve efficacy". Palomeque adds that the "unique design" of Oncoprex may have success in targeting the tumor suppressor gene.
09/14/18
09/14/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Shopify (SHOP) and Angi Homeservices (ANGI) initiated with an Outperform at Wedbush. 2. Griffon (GFF) initiated with a Neutral at Baird. 3. Genprex (GNPX) initiated with a Buy at Maxim. 4. Zogenix (ZGNX) initiated with a Buy at BofA/Merrill. 5. Masimo (MASI) initiated with a Buy at Needham. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
04/01/19
MAXM
04/01/19
DOWNGRADE
MAXM
Hold
Genprex downgraded to Hold from Buy at Maxim

TODAY'S FREE FLY STORIES

BYND

Beyond Meat

$155.04

1.31 (0.85%)

, TSLA

Tesla

$246.51

3.08 (1.27%)

16:48
09/19/19
09/19
16:48
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16:48
Hot Stocks
Beyond Meat names Sanjay Shah COO »

Beyond Meat (BYND)…

BYND

Beyond Meat

$155.04

1.31 (0.85%)

TSLA

Tesla

$246.51

3.08 (1.27%)

AMZN

Amazon.com

$1,822.21

4.21 (0.23%)

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SMTX

SMTC Corp.

$2.96

0.16 (5.71%)

16:40
09/19/19
09/19
16:40
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16:40
Earnings
SMTC Corp. guides initial FY20 revenue $390M-$410M, two estimate $421.85M »

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CLXT

Calyxt

$6.97

-0.2 (-2.79%)

16:40
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Calyxt signs seed agreement with Landus Cooperative in Iowa »

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SMTX

SMTC Corp.

$2.96

0.16 (5.71%)

16:39
09/19/19
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16:39
Earnings
SMTC Corp to exit China operations, cuts FY19 revenue view to $354M-$362M »

Two estimates $392.79M. …

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ACRGF

Acreage Holdings

$0.00

(0.00%)

16:36
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16:36
Initiation
Acreage Holdings initiated  »

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SMTX

SMTC Corp.

$2.96

0.16 (5.71%)

16:36
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16:36
Hot Stocks
Breaking Hot Stocks news story on SMTC Corp. »

SMTC Corp to exit China…

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16:35
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16:35
General news
Money Supply M2 Weekly Change data reported »

Week of 9/9 Money Supply…

16:35
09/19/19
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16:35
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16:35
General news
Fed Balance Sheet Level data reported »

Week of 9/18 Fed Balance…

FSLR

First Solar

$67.09

1.32 (2.01%)

16:35
09/19/19
09/19
16:35
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16:35
Hot Stocks
First Solar transitions to leveraging third-party EPC services »

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HEXO

HEXO Corp

$3.94

-0.175 (-4.25%)

16:35
09/19/19
09/19
16:35
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16:35
Initiation
HEXO Corp initiated  »

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  • 12

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CURLF

Curaleaf Holdings

$0.00

(0.00%)

16:34
09/19/19
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16:34
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16:34
Initiation
Curaleaf Holdings initiated  »

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  • 14

    Nov

CHNR

China Natural Resources

$2.53

0.13 (5.42%)

16:34
09/19/19
09/19
16:34
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16:34
Syndicate
Breaking Syndicate news story on China Natural Resources »

China Natural Resources…

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KEY

KeyCorp

$18.04

-0.18 (-0.99%)

16:32
09/19/19
09/19
16:32
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16:32
Hot Stocks
KeyCorp CEO Beth Mooney to retire »

KeyCorp announced that…

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  • 17

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ASA

ASA Limited

$12.56

0.25 (2.03%)

16:31
09/19/19
09/19
16:31
09/19/19
16:31
Hot Stocks
ASA Limited reports NAV positive 59.4% for 9 months ended August 31 »

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16:30
09/19/19
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Options
Preliminary option volume of 20.3M today »

Preliminary option volume…

NDLS

Noodles & Company

$5.92

-0.05 (-0.84%)

16:29
09/19/19
09/19
16:29
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16:29
Hot Stocks
Noodles & Company names Jeffrey Jones as board chairman »

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TLRY

Tilray

$29.91

-0.59 (-1.93%)

16:29
09/19/19
09/19
16:29
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16:29
Initiation
Tilray initiated  »

Tilray initiated with a…

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    Sep

MSFT

Microsoft

$141.08

2.55 (1.84%)

, TGT

Target

$107.84

0.92 (0.86%)

16:29
09/19/19
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16:29
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16:29
On The Fly
Fly Intel: Wall Street's top stories for Thursday »

Stocks spent the morning…

MSFT

Microsoft

$141.08

2.55 (1.84%)

TGT

Target

$107.84

0.92 (0.86%)

MO

Altria Group

$40.12

-0.72 (-1.76%)

PM

Philip Morris

$71.70

0.12 (0.17%)

GE

General Electric

$9.41

0.03 (0.32%)

CBPO

China Biologic

$113.97

10.78 (10.45%)

MLHR

Herman Miller

$45.05

0.57 (1.28%)

X

U.S. Steel

$11.06

-1.39 (-11.16%)

GRUB

GrubHub

$60.54

-3.245 (-5.09%)

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PGR

Progressive

$75.77

0.57 (0.76%)

16:28
09/19/19
09/19
16:28
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16:28
Hot Stocks
Progressive's Chief Investment Officer William Cody retiring, succesor appointed »

Progressive appointed…

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CGC

Canopy Growth

$26.33

-2.49 (-8.64%)

16:28
09/19/19
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16:28
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Initiation
Canopy Growth initiated  »

Canopy Growth initiated…

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CRON

Cronos Group

$10.23

-0.725 (-6.62%)

16:28
09/19/19
09/19
16:28
09/19/19
16:28
Initiation
Cronos Group initiated  »

Cronos Group initiated…

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ACB

Aurora Cannabis

$5.16

-0.11 (-2.09%)

16:27
09/19/19
09/19
16:27
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16:27
Initiation
Aurora Cannabis initiated  »

Aurora Cannabis initiated…

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AWK

American Water

$122.48

1.01 (0.83%)

16:26
09/19/19
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16:26
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16:26
Hot Stocks
Illinois American Water acquires Village of Glasford water, wastewater systems »

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  • 10

    Nov

NXST

Nexstar

$101.96

-1.23 (-1.19%)

, TRCO

Tribune Media

$46.66

(0.00%)

16:25
09/19/19
09/19
16:25
09/19/19
16:25
Hot Stocks
Nexstar completes accretive Tribune deal, sees 2019/2020 pro-forma FCF $1.02B »

Nexstar Media Group…

NXST

Nexstar

$101.96

-1.23 (-1.19%)

TRCO

Tribune Media

$46.66

(0.00%)

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  • 23

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STZ

Constellation Brands

$207.45

-0.06 (-0.03%)

, STZ.B

Constellation Brands; also tag STZ

$182.94

(0.00%)

16:25
09/19/19
09/19
16:25
09/19/19
16:25
Initiation
Constellation Brands, Constellation Brands; also tag STZ initiated  »

Constellation Brands…

STZ

Constellation Brands

$207.45

-0.06 (-0.03%)

STZ.B

Constellation Brands; also tag STZ

$182.94

(0.00%)

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