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GNPX

Genprex

$0.88

-0.0065 (-0.73%)

08:14
09/11/19
09/11
08:14
09/11/19
08:14

Genprex announces study that shows TUSC2 prevented tumor growth in TNBC

Genprex announced that independent researchers reported in a recent study that TUSC2, a tumor suppressor gene and the active agent in Genprex's Oncoprex immunogene therapy, prevented tumor growth in triple-negative breast cancer, or TNBC, which is currently considered an incurable cancer with limited therapeutic options. Genprex has no affiliation with these researchers. The study, published in Nature, first found MicroRNA-138 as a diagnostic biomarker for TNBC, which currently lacks targeted therapies due to its inability to express the estrogen and progesterone hormone receptors and the human epidermal growth factor receptor 2, or HER2, thus the name for triple-negative breast cancer. Depletion of miR-138 was found to lead to apoptotic cell death in vitro and prevented tumorigenesis in vivo. TUSC2 was found to be a direct target of miR-138, and TUSC2 mimics the effects of miR-138 knockdown, preventing tumor growth. The researchers deduced that TUSC2 is a downstream tumor suppressor that is directly repressed by miR-138. The study reports that triple-negative breast cancer is an extremely aggressive subtype of breast cancer which is associated with poor prognosis and high mortality rates. The lack of targeted treatment for triple-negative breast cancer makes it an increasingly feared diagnosis. Genprex is conducting clinical and pre-clinical research to evaluate the effectiveness of TUSC2 when combined with targeted therapies and immunotherapies for non-small cell lung cancer. Existing pre-clinical data also suggest that TUSC2 may be effective against glioblastoma, head and neck cancer, kidney cancer and soft tissue sarcomas. Now, this new independent study raises the possibility that TUSC2 expression, through miR-138 targeting, may also be used to treat the most aggressive subset of breast cancer.

GNPX Genprex
$0.88

-0.0065 (-0.73%)

09/14/18
MAXM
09/14/18
INITIATION
MAXM
Buy
Genprex initiated with a Buy at Maxim
09/14/18
MAXM
09/14/18
INITIATION
Target $5
MAXM
Buy
Genprex initiated with a Buy at Maxim
Maxin analyst Caroline Palomeque initiated Genprex with a Buy rating and a price target of $5. The analyst cites the potential of the company's lead therapeutic candidate Oncoprex in treating non-small cell lung cancer, with preclinical studies suggesting that the drug may "sensitize cancer cells to other targeted therapies and improve efficacy". Palomeque adds that the "unique design" of Oncoprex may have success in targeting the tumor suppressor gene.
09/14/18
09/14/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Shopify (SHOP) and Angi Homeservices (ANGI) initiated with an Outperform at Wedbush. 2. Griffon (GFF) initiated with a Neutral at Baird. 3. Genprex (GNPX) initiated with a Buy at Maxim. 4. Zogenix (ZGNX) initiated with a Buy at BofA/Merrill. 5. Masimo (MASI) initiated with a Buy at Needham. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
04/01/19
MAXM
04/01/19
DOWNGRADE
MAXM
Hold
Genprex downgraded to Hold from Buy at Maxim

TODAY'S FREE FLY STORIES

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UCBI

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ATR

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BUSE

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SMH

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REED

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KRG

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USO

United States Oil Fund

$11.35

0.145 (1.29%)

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LRN

K12

$24.84

-0.56 (-2.20%)

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BIIB

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MTH

Meritage Homes

$74.88

0.23 (0.31%)

16:36
10/22/19
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16:36
Earnings
Meritage Homes raises FY19 EPS view to $5.50-$5.70 from $5.20-$5.50 

Consensus $5.46.

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LRN

K12

$24.84

-0.56 (-2.20%)

16:34
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Earnings
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  • 22

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MTH

Meritage Homes

$74.88

0.23 (0.31%)

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Earnings
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LRN

K12

$24.84

-0.56 (-2.20%)

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Earnings
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  • 22

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MGNX

MacroGenics

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  • 06

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AMZN

Amazon.com

$1,766.07

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, MSFT

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MSFT

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TRMK

Trustmark

$34.83

-0.15 (-0.43%)

16:32
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Earnings
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FULT

Fulton Financial

$16.76

0.09 (0.54%)

16:32
10/22/19
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Earnings
Fulton Financial reports Q3 EPS 37c, consensus 35c »

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LRN

K12

$24.84

-0.56 (-2.20%)

16:32
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Earnings
K12 reports Q1 EPS (25c), consensus (19c) »

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  • 22

    Oct

IBIO

iBio

$0.57

0.0722 (14.44%)

16:31
10/22/19
10/22
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Earnings
iBio reports on NYSE American noncompliance notice, compliance plan »

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NTB

Butterfield

$30.90

-0.09 (-0.29%)

16:31
10/22/19
10/22
16:31
10/22/19
16:31
Earnings
Butterfield reports Q3 core EPS 91c, consensus 91c »

Net interest income…

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  • 23

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