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BLPH

Bellerophon

$0.57

0.0636 (12.66%)

08:37
10/23/19
10/23
08:37
10/23/19
08:37

Bellerophon presents data from Cohort 1 of Phase 2/3 study of INOpulse

Bellerophon Therapeutics presented additional new data from Cohort 1 of its ongoing Phase 2/3 randomized, double-blind, placebo-controlled clinical study of INOpuls for the treatment of Pulmonary Hypertension associated with Interstitial Lung Disease as a late-breaking oral presentation at the American College of Chest Physicians 2019 Annual Meeting in New Orleans. The data were presented by Steven D. Nathan, M.D., F.C.C.P., Medical Director of the Advanced Lung Disease and Lung Transplant Program at Inova Fairfax Hospital and Chair of Bellerophon's Steering Committee. Bellerophon previously presented positive top-line data from Cohort 1 of its ongoing iNO-PF trial. Cohort 1, the first of 3 cohorts, included 41 subjects randomized 1:1 to either iNO 30 or placebo, for a period of 8 weeks of blinded treatment. Data highlights included: MVPA improved by 34%. 23% of subjects on INOpulse had a clinically significant improvement in MVPA, compared to 0% of subjects on placebo. 39% of subjects on INOpulse had a clinically significant decline in MVPA, compared to 71% of subjects on placebo. Proportion of awake time spent in MVPA improved by 38%. Overall activity improved by 12%. The CHEST presentation included additional responder analysis data, as well as new long-term results for subjects on OLE. Presentation highlights included: Responder analysis: 85% of subjects on placebo declined in MVPA, overall activity and non-sedentary activity. 46% of subjects on INOpulse improved in MVPA, 62% in overall activity and 39% in non-sedentary activity. OLE: Collectively, subjects demonstrated maintenance of MVPA, overall activity and non-sedentary activity. Subjects randomized to active treatment in the blinded portion of the trial continued to maintain their activity levels when transitioning to OLE over 27 weeks of open-label treatment. Subjects randomized to placebo in the blinded portion of the trial transitioned from a decline during blinded treatment to stabilization of activity levels over 27 weeks of open-label treatment

BLPH Bellerophon
$0.57

0.0636 (12.66%)

01/24/19
MAXM
01/24/19
INITIATION
MAXM
Buy
Bellerophon initiated with a Buy at Maxim
01/24/19
MAXM
01/24/19
INITIATION
Target $3
MAXM
Buy
Bellerophon initiated with a Buy at Maxim
Maxim analyst Caroline Palomeque initiated Bellerophon with a Buy rating and a price target of $3, saying the company's lead product INOpulse is well positioned in the absence of other "FDA-approved treatment options for pulmonary hypertension associated with Interstitial Lung Disease". The analyst notes that shares were down significantly in Q3 of 2018 after the company's phase 3 study in pulmonary arterial hypertension was stopped for futility, but she sees upside from the program's intact clinical path forward and expectations of more data later this year.

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TORC

resTORbio

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WE

We Company

$0.00

(0.00%)

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FCBP

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AXP

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-0.03 (-0.02%)

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$NSD

NASDAQ Market Internals

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$NYE

NYSE Market Internals

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12:16
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