LivaNova announces publication of chronic epilepsy study
LivaNova announced the publication of a new study in Neurology, which suggests that chronic epilepsy may be associated with key measures of sudden cardiac death risk. This is the third in a series of studies to evaluate cardiac electrical instability in patients with chronic epilepsy, but the first to compare the cardiac impact of the disease among patients with chronic epilepsy to those who are newly diagnosed. The study in Neurology evaluated established markers of sudden cardiac death risk, T-wave alternans, or TWA, and heart rate variability, or HRV, in patients with chronic epilepsy compared to patients with newly diagnosed epilepsy. Using data recorded on ambulatory electrocardiographic monitors, the investigators assessed whether cardiac electrical instability indicated by TWA and abnormal autonomic tone measured by HRV result from recurrent seizures. Results from the analysis showed that chronic epilepsy is associated with higher TWA levels and simultaneously with lower HRV, suggesting autonomic dysfunction or higher sympathetic tone.