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AXLA

Axcella

$3.63

-0.83 (-18.61%)

08:07
12/07/19
12/07
08:07
12/07/19
08:07

Axcella says preclinical of AXA4010 data show multifactorial potential

Axcella Health announced mechanistic data for AXA4010 that are being presented today at the American Society of Hematology's Annual Meeting. Plasma amino profiles of adults with sickle cell disease were significantly different from adults in the control group, with a 50% reduction in Arginine and more than a 30% reduction in total essential amino acids, which include Leucine, Valine, Lysine, and Histidine, the company said in a statement. Endothelial cell cultures treated with TNFalpha and constituents of AXA4010 saw reduction in markers of vascular adhesion, inflammation and cell migration, it added. This was compared to cell cultures that were treated with glutamine and TNFalpha, which saw an increase in adhesion, no change in inflammation and a reduction in cell migration. Compared against individual amino acids, AXA4010 "constituents were better at improving overall RBC deformability by improving membrane flexibility, surface-to-volume ratio and intracellular viscosity," according to Axcella. "These data again demonstrate the potential of EMMs to impact multiple dysregulated metabolic pathways," said Bill Hinshaw, president and CEO of Axcella. "We are excited about the continued expansion of Axcella's portfolio beyond our liver- and muscle-related programs, into hematology."

AXLA Axcella
$3.63

-0.83 (-18.61%)

06/03/19
LEER
06/03/19
INITIATION
Target $21
LEER
Outperform
Axcella initiated with an Outperform at SVB Leerink
SVB Leerink analyst Geoffrey Porges started Axcella Health with an Outperform rating and $21 price target.
06/03/19
JPMS
06/03/19
INITIATION
Target $20
JPMS
Overweight
Axcella initiated with an Overweight at JPMorgan
JPMorgan analyst Jessica Fye started Axcella with an Overweight rating and $20 price target. The company's data readouts over the next 12-18 months could lend further support to the company's mechanism of action and drive upside over time, Fye tells investors in a research note. The analyst sees am "interesting entry point" in a company with potential for long-term value creation.
06/03/19
06/03/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. DuPont (DD) initiated with an Overweight at Morgan Stanley. 2. Corteva (CTVA) was initiated with an Outperform at BMO Capital, an Equal Weight at Morgan Stanley, a Neutral at Goldman Sachs and Citi, as well as a Hold at SunTrust and Deutsche Bank. 3. Axcella (AXLA) was initiated with an Overweight at JPMorgan, an Outperform at SVB Leerink, and a Buy at Goldman Sachs. 4. Cortexyme (CRTX) was initiated with an Outperform at JMP Securities, a Buy at Canaccord, a Neutral at BofA/Merrill, and an Underperform at Credit Suisse. 5. Mayville Engineering (MEC) was initiated with an Outperform at Baird, a Buy at Jefferies and Citi, and a Neutral at UBS. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
10/24/19
10/24/19
NO CHANGE

Citigroup to hold a conference call
Conference call to discuss 3Q19 Fixed Income Investor Review will be held on October 29 at 11 am. Reference Link

TODAY'S FREE FLY STORIES

TWLO

Twilio

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0.47 (0.39%)

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NTDOY

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WILC

G. Willi-Food

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ELAN

Elanco

$31.41

0.77 (2.51%)

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Elanco Animal Health call volume above normal and directionally bullish »

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HUYA

Huya

$18.73

-1.75 (-8.54%)

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CMRE

Costamare

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-1.34 (-12.95%)

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CANG

Cango

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-0.71 (-8.89%)

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OCFT

OneConnect

$15.17

1.2 (8.59%)

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BDRBF

Bombardier

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(0.00%)

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  • 13

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FSB

Franklin Financial Network

$38.25

4.13 (12.10%)

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EXPR

Express

$4.88

0.73 (17.59%)

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BTI

British American Tobacco

$44.63

0.06 (0.13%)

11:56
01/22/20
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11:56
Upgrade
British American Tobacco rating change  »

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SPR

Spirit AeroSystems

$64.32

-0.24 (-0.37%)

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Spirit AeroSystems put volume heavy and directionally bearish »

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HARL

Harleysville Savings Financial Corp

$0.00

(0.00%)

11:53
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  • 22

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HARL

Harleysville Savings Financial Corp

$0.00

(0.00%)

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  • 22

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CATC

Cambridge Bancorp

$75.85

0.35 (0.46%)

11:48
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Downgrade
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WU

Western Union

$27.46

0.14 (0.51%)

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  • 11

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CS

Credit Suisse

$13.55

-0.095 (-0.70%)

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  • 23

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BTI

British American Tobacco

$44.44

-0.13 (-0.29%)

11:43
01/22/20
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British American Tobacco rating change  »

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UBSFY

Ubisoft

$0.00

(0.00%)

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Tencent

$0.00

(0.00%)

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UBSFY

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TCEHY

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(0.00%)

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  • 13

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PTON

Peloton

$32.41

0.39 (1.22%)

11:36
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  • 05

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BA

Boeing

$307.20

-6.11 (-1.95%)

, BHC

Bausch Health

$29.77

0.02 (0.07%)

11:28
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On The Fly
Boeing downgrade, Bausch upgrade among today's top analyst calls »

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BA

Boeing

$307.20

-6.11 (-1.95%)

BHC

Bausch Health

$29.77

0.02 (0.07%)

NPTN

NeoPhotonics

$9.02

0.44 (5.13%)

FTNT

Fortinet

$119.16

1.59 (1.35%)

TSLA

Tesla

$583.29

35.86 (6.55%)

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JMIA

Jumia Technologies

$8.30

-0.02 (-0.24%)

11:25
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Options
Jumia Technologies call volume above normal and directionally bullish »

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TAP

Molson Coors

$56.43

-0.07 (-0.12%)

11:25
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Molson Coors craft division agrees to acquire Atwater Brewery »

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