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APTO

Aptose Biosciences

$2.55

-0.04 (-1.54%)

12:11
12/07/19
12/07
12:11
12/07/19
12:11

Aptose reports CG-806 data in patients with chronic lymphocytic leukemia

Aptose Biosciences released highlights from a corporate event and clinical update held at the American Society of Hematology Annual Meeting. The company said, "As the first clinical data from CG-806 in patients with chronic lymphocytic leukemia have begun to emerge, Drs. Howell, Bejar, and Druker highlighted the consistency between the drug's robust preclinical profile and the early clinical observations on safety, tolerability, pharmacokinetics, and activity. William G. Rice, Ph.D., Chairman, President and Chief Executive Officer of Aptose also provided a corporate update on the clinical activities of CG-806, Aptose's highly potent pan-FLT3/pan-BTK inhibitor." Key findings from dose levels 1 and 2 of CG-806 in heavily pretreated R/R chronic lymphocytic leukemia patients: "CG-806's safety profile remains clean; no unexpected toxicities have been observed to date...Early evidence of clinical response has already been observed in a R/R CLL patient at dose level 2...Evidence of Bruton's tyrosine kinase target engagement...Meaningful oral absorption and predictable pharmacokinetic profile...Exposures are likely therapeutic for acute myeloid leukemia patients." The company added APTO-253 is "demonstrating safety and MYC target engagement in a Phase 1b clinical trial for the treatment of patients with relapsed or refractory AML or high-risk myelodysplastic syndrome." It continues to escalate dosing with both assets, as all current dose cohorts to date have exhibited favorable safety profiles and evidence of target engagement.

APTO Aptose Biosciences
$2.55

-0.04 (-1.54%)

01/25/19
OPCO
01/25/19
INITIATION
Target $6
OPCO
Outperform
Aptose Biosciences initiated with an Outperform at Oppenheimer
As previously reported, Oppenheimer analyst Matthew Biegler initiated Aptose Biosciences with an Outperform rating and $6 price target, citing the commercial potential of CG-806 in two major hematology/oncology indications. In a research note to investors, Biegler says he believes CG-806 can selectively disable key signaling pathways that cancer cells need without the "safety baggage" usually associated with multi-kinase inhibitors. Biegler says he would be a buyer of Aptose ahead of CG-806's expected 1H19 entry into the clinic.
01/25/19
01/25/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. SS&C (SSNC) initiated with a Buy at Buckingham. 2. Capital Southwest (CSWC) initiated with a Neutral at B. Riley FBR. 3. Natural Gas Services (NGS) initiated with a Buy at Maxim. 4. Aptose Biosciences (APTO) initiated with an Outperform at Oppenheimer. 5. AzurRx BioPharma (AZRX) initiated with a Buy at Roth Capital. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
03/01/19
RBCM
03/01/19
INITIATION
Target $6
RBCM
Outperform
Aptose Biosciences initiated with an Outperform at RBC Capital
RBC Capital analyst Gregory Renza initiated Aptose Biosciences with an Outperform and $6 price target citing the promising profile and solid per-clinical data for key asset CG-806. Renza sees an opportunity as clinical data generated to de-risk and increase appreciation for its prospects in the complex heme/onc treatment paradigm and a driver of share upside.
03/01/19
RBCM
03/01/19
INITIATION
Target $6
RBCM
Outperform
Aptose Biosciences initiated with an Outperform at RBC Capital
RBC Capital analyst Gregory Renza started Aptose Biosciences with an Outperform rating and $6 price target, stating that he believes key asset CG-806 has a "promising profile and solid pre-clinical data" in targeted oncology.

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