Galectin NASH-CX Phase 2 clinical trial results published in Gastroenterology
Galectin Therapeutics announced that a paper highlighting the results of its NASH-CX Phase 2 clinical trial in NASH cirrhosis have been published in the peer-reviewed journal Gastroenterology. The paper, titled "Effects of Belapectin, an Inhibitor of Galectin-3, in Patients with Nonalcoholic Steatohepatitis with Cirrhosis and Portal Hypertension," was authored primarily by Naga Chalasani, M.D., of the Indiana University School of Medicine with the extensive support and assistance of many others. "The paper outlines that in a phase 2b study of 162 patients with NASH, cirrhosis, and portal hypertension, one year of biweekly infusion of belapectin was safe but not associated with significant reduction in HVPG or fibrosis, compared with placebo. However, in a subgroup analysis of patients without esophageal varices, 2 mg/kg belapectin (GR-MD-02) did reduce HVPG and development of varices. This subgroup analysis suggests that there may be benefits from belapectin in patients with NASH cirrhosis without esophageal varices. Further, if this observation can be reproduced in subsequent studies, belapectin may have a role in the management of patients with NASH cirrhosis and portal hypertension but no varices. Galectin Therapeutics is planning an adaptively-designed Phase 3 trial of belapectin in NASH cirrhosis patients as previously disclosed."