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TLSA

Tiziana Life Sciences

$2.60 /

+0.06 (+2.36%)

07:25
01/09/20
01/09
07:25
01/09/20
07:25

Tiziana Life Sciences reports completion of Phase 1 Foralumab

Tiziana Life Sciences reported the completion of a Phase 1 clinical study of Foralumab, a fully human anti-CD3 monoclonal antibody, or mAb, in healthy subjects. The proprietary oral formulation, comprising the lyophilized and stabilized free-flowing powder of formulated Foralumab encapsulated in an enteric-coated capsule, was well-tolerated at all doses tested and there were no drug-related safety issues even at the highest dose of 5 mg in this trial. This Phase 1 trial, conducted at the Brigham and Women's Hospital, Harvard Medical School, was a single-site, double-blind, placebo-controlled, single ascending dose, or SAD, study in healthy subjects in which Foralumab was orally administered at 1.25, 2.5 and 5.0 mg per dose as enteric-coated capsules. Each cohort comprised of 4 subjects, of whom 3 received Foralumab treatment and 1 received a placebo capsule. All subjects completed the trial without any safety concerns at any of the doses. It has previously been shown that orally administered Foralumab to NOD/SCID IL2?c-/- mice with skin xenografts was well-tolerated up to 15 microg/day for five days then weekly, prevented skin xenograft rejection indefinitely. Clinical studies conducted by other researchers have also shown that oral administration of OKT3, a murine anti-CD3 mAb, was well-tolerated up to 5 mg/day for 5 days to healthy subjects, to patients with nonalcoholic steatohepatitis for 30 days and to hepatitis C virus non-responders for 30 days. Data from a recently completed clinical study indicated that oral administration of OKT3 was well tolerated at 1 mg/day for 30 consecutive doses in patients with moderate-to-severe ulcerative colitis. Importantly, the treatment resulted in clinical responses in 3 out of 6 patients, including one patient with a complete clinical response.

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Diageo initiated with a Buy at Goldman Sachs » 19:45
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AB InBev initiated with a Neutral at Goldman Sachs » 19:40
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AB InBev

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Initiation
Britvic initiated with a Buy at Goldman Sachs » 19:33
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Britvic

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Pernod Ricard initiated with a Buy at Goldman Sachs » 19:30
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Pernod Ricard

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Hot Stocks
Fly Intel: After Hours Movers » 19:05
02/25/20
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19:05
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ACRS

Aclaris Therapeutics

$1.38 /

-0.04 (-2.82%)

, WW

WW

$34.84 /

-2.05 (-5.56%)

, MTDR

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$10.88 /

-1.32 (-10.82%)

, BGS

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$12.78 /

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, ALRM

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$44.82 /

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, NVRO

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$132.50 /

-3.01 (-2.22%)

, INFN

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$7.90 /

-0.2 (-2.47%)

, EVH

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$10.18 /

-1.13 (-9.99%)

, PRTK

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$3.58 /

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, ADMS

Adamas Pharmaceuticals

$4.77 /

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, AKCA

Akcea Therapeutics

$17.09 /

+0.29 (+1.73%)

, SDC

SmileDirectClub

$11.33 /

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, RVLV

Revolve Group

$19.93 /

+1 (+5.28%)

, SUPN

Supernus

$22.93 /

-1.04 (-4.34%)

, PODD

Insulet

$197.03 /

-10.46 (-5.04%)

, SCCO

Southern Copper

$35.05 /

-1.09 (-3.02%)

, TOL

Toll Brothers

$44.28 /

-2.765 (-5.88%)

, VICR

Vicor Corporation

$47.89 /

-0.14 (-0.29%)

, PEN

Penumbra

$176.15 /

-8.13 (-4.41%)

, UIS

Unisys

$15.88 /

-0.405 (-2.49%)

, PLNT

Planet Fitness

$81.51 /

-2.87 (-3.40%)

, SPCE

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$33.65 /

-0.51 (-1.49%)

, REAL

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$14.99 /

+0.03 (+0.20%)

, ORA

Ormat Technologies

$79.94 /

-3.12 (-3.76%)

, IOVA

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$31.61 /

+6.92 (+28.03%)

, EXEL

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$19.42 /

-0.76 (-3.77%)

, EVTC

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$31.36 /

-0.65 (-2.03%)

, CRM

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$181.65 /

-4.26 (-2.29%)

, JAZZ

Jazz Pharmaceuticals

$127.50 /

-3.31 (-2.53%)

, CZR

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$13.33 /

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, AMRN

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$17.54 /

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, RRGB

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$31.32 /

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, VNDA

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$11.51 /

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, DIS

Disney

$128.24 /

-4.79 (-3.60%)

UP AFTER EARNINGS:…

UP AFTER EARNINGS: Aclaris (ACRS) up 8.0%... WW International (WW) up 6.8%... Matador Resources (MTDR) up 6.0%... B&G Foods (BGS) up 5.7%... Alarm.com (ALRM) up 5.3%... Nevro (NVRO) up 3.4%... Infinera (INFN) up 3.4%... Evolent Health (EVH) up 3.1%... Paratek Pharma (PRTK) up 2.8%... Adamas Pharma (ADMS) up 1.9%... Akcea Therapeutics (AKCA) up 1.9%. DOWN AFTER EARNINGS: SmileDirectClub (SDC) down 20.5%... Revolve Group (RVLV) down 18.1%... Supernus Pharma (SUPN) down 15.0%... Insulet (PODD) down 12.1%... Southern Copper (SCCO) down 9.3%... Toll Brothers (TOL) down 9.0%... Vicor Corp (VICR) down 8.7%... Penumbra (PEN) down 6.9%... Unisys (UIS) down 6.1%... Planet Fitness (PLNT) down 5.9%... Virgin Galactic (SPCE) down 5.7%... RealReal (REAL) down 5.1%... Ormat Technologies (ORA) down 3.8%... Iovance Biotherapeutics (IOVA) down 3.1%... Exelixis (EXEL) down 3.1%... Evertec (EVTC) down 3.0%... Salesforce (CRM) down 2.1%... Jazz Pharma (JAZZ) down 1.8%... Caesars (CZR) down 1.6%... Amarin Corp (AMRN) down 1.4%... Red Robin (RRGB) down 1.3%. ALSO LOWER: Vanda Pharma (VNDA) down 7.6% after Phase 3 study of tradipitant did not meet primary endpoint... Disney (DIS) down 1.7% after naming new CEO. Movers as of 18:30ET.

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eBay to begin managing payments in U.K. » 19:02
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Recommendations
Kura Oncology price target cut to $30 from $32 at Piper Sandler » 18:47
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KURA

Kura Oncology

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CRM

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-4.26 (-2.29%)

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SEC, SDNY looking into Mattel's accounting » 18:41
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MAT

Mattel

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-0.5 (-4.03%)

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MasterCard CEO: It's a good time for me to step aside » 18:24
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MA

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TransUnion director sells 7.8K shares of common stock » 18:18
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TransUnion

$94.77 /

-2.33 (-2.40%)

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Periodicals
Envoy says White House in talks over Chevron's Venezuela ops, Reuters reports » 18:14
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CVX

Chevron

$100.75 /

-3.97 (-3.79%)

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Uber Eats head Droege to leave company » 18:10
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Uber

$35.86 /

-2.44 (-6.37%)

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Earnings
Tronox sees FY20 adjusted EPS 55c-$1.10, consensus $1.47 » 18:07
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TROX

Tronox

$7.57 /

-1.27 (-14.37%)

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Earnings
Tronox reports Q4 adjusted EPS 14c, consensus 12c » 18:04
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Tronox

$7.57 /

-1.27 (-14.37%)

Reports Q4 revenue $693M,…

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Periodicals
Royal Dutch Shell plans major deep-water drilling in Mexico, Bloomberg reports » 17:59
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RDS.A

Royal Dutch Shell

$45.91 /

-1.38 (-2.92%)

, RDS.B

Royal Dutch Shell

$46.23 /

-1.29 (-2.71%)

Royal Dutch Shell is…

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Hot Stocks
ShotSpotter CFO Alan Stewart sells almost 10K shares of company stock » 17:52
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SSTI

ShotSpotter

$36.57 /

-0.53 (-1.43%)

ShotSpotter CFO Alan…

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Hot Stocks
ShotSpotter CEO Ralph Clark sells almos $1.6M in company shares » 17:50
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17:50
SSTI

ShotSpotter

$36.57 /

-0.53 (-1.43%)

ShotSpotter CEO Ralph…

ShotSpotter CEO Ralph Clark disclosed in a filing that he had sold 42,764 shares of company stock at an average price of $36.60 per share between February 21 and February 25. The total transaction value of the sale was $1,565,004.

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Galaxy Gaming to acquire Progressive Games Partners for $12.4M » 17:43
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GLXZ

Galaxy Gaming

$0.00 /

+ (+0.00%)

Galaxy Gaming announced…

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Wyndham Hotels & Resorts raises quarterly dividend to 32c from 29c per share » 17:42
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WH

Wyndham Hotels & Resorts

$53.42 /

-2.77 (-4.93%)

Payable March 31 to…

Payable March 31 to shareholders of record as of March 13.

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Earnings
Weingarten Realty sees FY20 core FFO $2.06-$2.11, consensus $2.13 » 17:39
02/25/20
02/25
17:39
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17:39
WRI

Weingarten Realty

$29.60 /

-1.07 (-3.49%)

"We continue to…

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Earnings
Weingarten Realty reports Q4 core FFO 53c, consensus 53c » 17:38
02/25/20
02/25
17:38
02/25/20
17:38
WRI

Weingarten Realty

$29.60 /

-1.07 (-3.49%)

Reports Q4 revenue…

Reports Q4 revenue $119.47M, consensus $119.02M. "Our greatly transformed portfolio continues to produce solid operating results. Leasing activity was strong, generating increased rental rates on new leases during the quarter of 16%. Coupled with low tenant fallout, this resulted in an 80 basis points increase over the prior year in total occupancy with our shop space rising to a record 90.8%. Same Property NOI was also strong, increasing 3.3% during the year. While there are continued challenges in the retail marketplace, the improved quality of our portfolio clearly enables us to respond to these challenges much more effectively," said Johnny Hendrix, Executive Vice President and Chief Operating Officer.

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Oasis Petroleum sees FY20 production 82.5-86.5 MBOE/d » 17:36
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OAS

Oasis Petroleum

$1.77 /

-0.1 (-5.35%)

Sees Q1 total volumes to…

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