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NKTR

Nektar

$24.02

2.49 (11.57%)

10:09
01/10/20
01/10
10:09
01/10/20
10:09

FDA discusses abuse potential for Nektar's NKTR-181 in briefing docs

The FDA released background information prepared by the Food and Drug Administration for the panel members of the advisory committee being convened to advise on the new drug application 211802 for oxycodegol for management of chronic low back pain in adult patients with pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative options are inadequate. The document states in part: "The results of human abuse potential Study 15-181-15 and the occurrence of adverse events are indicative of abuse potential in the clinical development program. NKTR-181 demonstrates an oral abuse potential comparable to oxycodone following oral administration. Results from Study 15-181-15 indicate that oxycodone, as a metabolite of NKTR-181, contributes in part to the subjective effects seen following oral administration of NKTR-181." Reference Link

  • 14

    Jan

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    Feb

NKTR Nektar
$24.02

2.49 (11.57%)

11/11/19
HCWC
11/11/19
NO CHANGE
Target $32
HCWC
Neutral
Nektar price target raised to $32 from $24 at H.C. Wainwright
H.C. Wainwright analyst Debjit Chattopadhyay raised his price target for Nektar Therapeutics to $32 from $24 while maintaining a Neutral rating on the shares. Durability in frontline melanoma is reassuring following this weekend's data, says Chattopadhyay, who notes he remains "wary." Reasons to be cautious on the new data include the sample size of 41, of which three have been excluded from analysis for a variety of reasons as disclosed previously, and patients having healthier baseline characteristics than historical studies, Chattopadhyay tells investors in a research note.
11/11/19
HCWC
11/11/19
NO CHANGE
Target $30
HCWC
Buy
Synthorx drug may be safer alternative to Nektar's, says H.C. Wainwright
H.C. Wainwright analyst Debjit Chattopadhyay says Synthorx's (THOR) THOR-707 is "creeping up" on Nektar Therapeutics' (NKTR) bempeg. With THOR-707's profile, the analyst anticipates "profound changes to the pre- and post-treatment biomarkers" when compared to bempeg. In addition, THOR-809 is "poised to be the safer alternative" when compared to Nektar's NKTR-358, Chattopadhyay tells investors in a research note. THOR-809 is "bestowed with a superior ability" to expand CD4 and CD25 and :markedly less" impact on NK cell proliferation compared to NKTR-358, contends the analyst. Chattopadhyay keeps a Buy rating on Synthorx with a $30 price target.
11/12/19
ADAM
11/12/19
NO CHANGE
Target $24
ADAM
Buy
Nektar price target raised to $24 from $20 at Canaccord
Canaccord analyst Arlinda Lee raised his price target on Nektar to $24 from $20 following its positive presentation of its Phase 1 PIVOT-2 update. The analyst said the increase reflects its increased melanoma prospects and success probability. Lee reiterated her Buy rating on Nektar shares.
01/10/20
HCWC
01/10/20
NO CHANGE
HCWC
Amended Nektar, Bristol pact reflects bempeg limitations, says H.C. Wainwright
No longer nine malignancies spread across 20 lines of treatment, the amended collaboration between Nektar Therapeutics (NKTR) and Bristol-Myers Squibb (BMY) limits bempeg to basically three tumor types, H.C. Wainwright analyst Debjit Chattopadhyay tells investors in a research note. While these programs are to be jointly funded, Bristol would independently conduct and fund a Phase 1/2 dose optimization and expansion study in first-line non-small-cell lung cancer with bempeg and nivolumab, which is a tacit admission of impeding competition from THOR-707, contends the analyst. He believes that should THOR-707 live up to its expectations, any wins for the bempeg combo "could prove to be ephemeral." Chattopadhyay keeps a Neutral rating on Nektar shares with a $32 price target.

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FDEF

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STIM

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TGP

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