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ARAV

Aravive

$13.14

-0.6 (-4.37%)

08:05
01/13/20
01/13
08:05
01/13/20
08:05

Aravive receives IND clearance for Phase 1b/Phase 2 trial of AVB-500

Aravive announced that the U.S. Food and Drug Administration has cleared the company's Investigational New Drug application for investigation of the company's lead candidate, AVB-500, for the treatment of clear cell renal cell carcinoma. The study has a Phase 1b safety portion and a Phase 2 randomized, controlled portion. The Phase 1b portion will investigate the safety and tolerability of escalating doses of AVB-500 in combination with cabozantanib in patients with advanced clear cell renal cell carcinoma that have progressed with or were intolerant to front-line treatment. The primary endpoints for the Phase 1b portion of the clinical trial are safety, pharmacokinetic and pharmacodynamic measurements with secondary endpoints including preliminary activity measures. The Phase 2 portion of the study will investigate the recommended AVB-500 dose identified during the Phase 1b portion in combination with cabozantinib versus cabozantinib alone in patients with advanced clear cell renal cell carcinoma that have progressed with or were intolerant to front-line treatment. The primary endpoint will be progression free survival. The clinical trial will also explore AVB-500 effects on biomarkers (GAS6) in serum.

ARAV Aravive
$13.14

-0.6 (-4.37%)

12/10/19
CANT
12/10/19
INITIATION
Target $30
CANT
Overweight
Aravive initiated with an Overweight, $30 price target at Cantor Fitzgerald
Cantor Fitzgerald analyst Louise Chen last night initiated coverage of Aravive with an Overweight rating and $30 price target. The analyst believes upwards earnings revisions driven by positive data readouts from Aravive's pipeline will drive shares higher. Chen expects multiple clinical and program milestones in 2019 and beyond and notes the company's lead product candidate is AVB-500 for cancer and fibrosis..
12/10/19
12/10/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Restaurant Brands (QSR), Domino's Pizza (DPZ), McDonald's (MCD), and Starbucks (SBUX) were initiated with Outperform ratings at RBC Capital, while Wendy's (WEN), Chipotle (CMG), Dunkin' Brands (DNKN), Brinker (EAT), Yum! Brands (YUM), and Texas Roadhouse (TXRH) were initiated with Sector Perform ratings. 2. Aravive (ARAV) initiated with an Overweight at Cantor Fitzgerald. 3. Borr Drilling (BORR) initiated with a Buy at Goldman Sachs. 4. Axon (AAXN) initiated with an Outperform at JMP Securities. 5. Zoom Video (ZM) initiated with a Neutral at Piper Jaffray. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
12/20/19
HCWC
12/20/19
NO CHANGE
Target $25
HCWC
Buy
Aravive price target lowered to $25 from $31 at H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis lowered his price target for Aravive to reflect dilution from the November equity raise. The company this morning announced the expected initiation of a Phase 2a with AVB-500 in patients with kidney fibrosis, specifically IgA Nephropathy based on the expression of GAS6 more predominantly in IgAN tissue than normal tissue. The analyst views IgAN as a "risky but real opportunity" for Aravive and he keeps a Buy rating on the shares.
12/20/19
PIPR
12/20/19
NO CHANGE
PIPR
Piper Jaffray reiterates Overweight on Aravive after Phase IIa study initiation
Piper Jaffray analyst Edward Tenthoff reiterated an Overweight rating and $31 price target on Aravive following the company's initiation of a Phase IIa study of AVB-500 in IgA nephropathy patients. The analyst noted that safety has remained clean, and that predictive modeling shows that AVB-500 "should provide sufficient exposure for therapeutic efficacy and may support a pivotal trial start next year." Tenthoff also noted that Aravive intends to start AVB-500 studies in kidney cancer and IgA nephropathy.

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FB

Facebook

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TSLA

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JPM

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BAC

Bank of America

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CEL

Cellcom Israel

$3.18

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VRCA

Verrica Pharmaceuticals

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SO

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1.08 (1.63%)

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LIZI

Lizhi

$11.72

(0.00%)

, DNK

Phoenix Tree

$13.50

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$0.00

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TLGT

Teligent

$0.40

-0.0025 (-0.62%)

15:53
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AYTU

Aytu BioScience

$0.80

0.0014 (0.18%)

15:48
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    Jan

DVA

DaVita

$79.45

0.43 (0.54%)

15:32
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TSM

TSMC

$58.58

-0.18 (-0.31%)

09:16
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KKR

KKR

$31.20

0.7 (2.30%)

, APO

Apollo Global

$50.35

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SPCE

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GOOG

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SPOT

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CE

Celanese

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BYND

Beyond Meat

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DBD

Diebold

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IEF

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$111.28

-0.13 (-0.12%)

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$84.73

-0.005 (-0.01%)

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SHY

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$84.73

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SPY

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$331.98

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SLV

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$16.82

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UBSFY

Ubisoft

$0.00

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IMVT

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17:27
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