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VRNA

Verona Pharma

$5.98 /

+0.38 (+6.79%)

09:11
01/13/20
01/13
09:11
01/13/20
09:11

Verona Pharma says Phase 2b COPD study met primary endpoint at all doses

Verona Pharma announced top-line data from a 4 week, 416 patient, Phase 2b dose-ranging study evaluating nebulized ensifentrine or placebo as an add-on treatment to tiotropium, a long acting anti-muscarinic bronchodilator, in patients with moderate to severe chronic obstructive pulmonary disease. The study met its primary endpoint of improved lung function, with ensifentrine added on to inhaled tiotropium, a LAMA commonly used to treat COPD. Ensifentrine produced a clinically and statistically significant, and dose-dependent improvement in peak forced expiratory volume in one second at week 4 compared to placebo added on to tiotropium. Highlights for ensifentrine as an add-on to tiotropium: Primary endpoint met at all doses: statistically significant and clinically meaningful improvement in lung function at week 4. Improvements ranged from 78 mL for the 0.375 mg dose to 124 mL for the 3.0 mg dose. Effects were maintained over 4 weeks. Dose-dependent improvements in lung function were observed on both peak FEV1 and FEV1 AUC 0-12 hours2. Statistically significant improvement in average FEV1 AUC 0-12 hours of 87 mL for the 3.0 mg dose is supportive of twice daily dosing.Clinically meaningful improvements in health-related quality of life were observed on top of tiotropium, exceeding the minimal clinically important difference of 4 units compared to placebo at week 4, with the two highest doses also achieving statistical significance. Ensifentrine was well tolerated at all doses with an adverse event profile similar to placebo. These data support dose selection for Phase 3.

  • 13

    Jan

VRNA Verona Pharma
$5.98 /

+0.38 (+6.79%)

01/14/19 WEDB
Wedbush says time to buy Verona Pharma, reaction to 3 day combo Phase 2 overdone
04/17/19 BTIG
Verona Pharma initiated with a Buy at BTIG
04/17/19 BTIG
Verona Pharma initiated with a Buy at BTIG

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Periodicals
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Earnings
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Recommendations
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Hot Stocks
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