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SNY

Sanofi

$52.42 /

+0.34 (+0.65%)

08:37
09/21/20
09/21
08:37
09/21/20
08:37

Sanofi presents trial data for investigational use of Libtayo in NSCLC

Positive pivotal trial data for the investigational use of PD-1 inhibitor Libtayo in first-line locally advanced or metastatic non-small cell lung cancer were shared in a presentation at the European Society for Medical Oncology Virtual Congress 2020. The trial compared Libtayo monotherapy to platinum-doublet chemotherapy in patients whose tumor cells expressed PD-L1, including those whose cancers had confirmed PD-L1 expression of greater than or equal to50%.These results form the basis of regulatory submissions, including in the U.S. and European Union. The late-breaking ESMO presentation expands on topline results shared in April. In the overall trial population, the median follow-up was 13 months for both Libtayo and chemotherapy. Among these patients, Libtayo demonstrated the following results compared to chemotherapy: 32% reduced risk of death. 22-month median overall survival compared to 14 months. 41% reduced risk of disease progression. The median progression-free survival was 6.2 months compared to 5.6 months. 37% objective response rate compared to 21% ORR. A prespecified analysis of data from patients whose cancers had confirmed PD-L1 expression greater than or equal to50% was also conducted. In this group, the median follow-up was 11 months for both Libtayo and chemotherapy, and Libtayo demonstrated the following results compared to chemotherapy: 43% reduced risk of death. Median OS was not yet reached compared to 14 months. 46% reduced risk of disease progression. The median PFS was 8 months compared to 6 months. 39% ORR compared to 20% ORR. The trial also found a direct correlation between tumor response and PD-L1 expression level in Libtayo-treated patients. The ORR was highest in tumors with greater than or equal to90% PD-L1 expression, with target tumors shrinking by more than 40% after 6 months of treatment on average. This correlation with PD-L1 expression level was not observed with chemotherapy. In the overall trial population, the median duration of exposure to Libtayo was 27 weeks and 18 weeks for chemotherapy. Overall adverse events occurred in 88% of Libtayo patients and 94% of chemotherapy patients. Grade 3 or higher AEs occurred in 37% of Libtayo patients and 49% of chemotherapy patients. Immune-mediated AEs were reported in 17% of Libtayo patients and included hypothyroidism, hyperthyroidism, pneumonitis, hepatitis, skin adverse reaction, arthritis, increased blood thyroid stimulating hormone, thyroiditis, colitis, nephritis and peripheral neuropathy. Treatment discontinuation due to an AE occurred in 6% of Libtayo patients and 4% of chemotherapy patients. No new Libtayo safety signals were observed. Libtayo is being jointly developed by Regeneron and Sanofi under a global collaboration agreement. The use of Libtayo to treat advanced NSCLC is investigational and has not been fully evaluated by any regulatory authority.

  • 21

    Sep

  • 23

    Sep

SNY Sanofi
$52.42 /

+0.34 (+0.65%)

09/14/20 Roth Capital
Immunic has 'significant' opportunity in RRMS, says Roth Capital
08/24/20 SVB Leerink
SVB Leerink continues to view Alexion as good M&A fit for number of suitors
08/19/20 Stifel
Principia Biopharma downgraded to Hold from Buy at Stifel
08/18/20 SVB Leerink
Principia Biopharma downgraded to Market Perform at SVB Leerink

TODAY'S FREE FLY STORIES

Recommendations
Glencore price target raised to 250 GBp from 240 GBp at Deutsche Bank » 11:41
11/25/20
11/25
11:41
11/25/20
11:41
GLNCY

Glencore

$0.00 /

+ (+0.00%)

Deutsche Bank analyst…

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GLNCY Glencore
$0.00 /

+ (+0.00%)

GLNCY Glencore
$0.00 /

+ (+0.00%)

11/24/20 Barclays
Glencore price target lowered to 210 GBp from 220 GBp at Barclays
11/24/20 Jefferies
Glencore upgraded to Buy from Hold at Jefferies
10/07/20 JPMorgan
Glencore upgraded to Neutral from Underweight at JPMorgan
09/24/20 Morgan Stanley
Glencore price target raised to 221 GBp from 220 GBp at Morgan Stanley
GLNCY Glencore
$0.00 /

+ (+0.00%)

Periodicals
Salesforce has recently held talks to buy Slack, WSJ reports  11:40
11/25/20
11/25
11:40
11/25/20
11:40
WORK

Slack Technologies

$29.73 /

+0.16 (+0.54%)

, CRM

Salesforce

$263.72 /

+3.01 (+1.15%)

 
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WORK Slack Technologies
$29.73 /

+0.16 (+0.54%)

CRM Salesforce
$263.72 /

+3.01 (+1.15%)

WORK Slack Technologies
$29.73 /

+0.16 (+0.54%)

11/23/20 KeyBanc
Slack Technologies initiated with a Sector Weight at KeyBanc
11/23/20 KeyBanc
Slack Technologies initiated with a Sector Weight at KeyBanc
10/23/20 Barclays
Slack Technologies price target raised to $36 from $31 at Barclays
10/21/20
Fly Intel: Top five analyst downgrades
CRM Salesforce
$263.72 /

+3.01 (+1.15%)

09:19 Today BMO Capital
Salesforce price target raised to $285 from $260 at BMO Capital
11/23/20 KeyBanc
Salesforce initiated with an Overweight at KeyBanc
11/23/20 KeyBanc
Salesforce initiated with an Overweight at KeyBanc
11/22/20 Jefferies
Salesforce price target raised to $320 from $285 at Jefferies
WORK Slack Technologies
$29.73 /

+0.16 (+0.54%)

CRM Salesforce
$263.72 /

+3.01 (+1.15%)

WORK Slack Technologies
$29.73 /

+0.16 (+0.54%)

CRM Salesforce
$263.72 /

+3.01 (+1.15%)

WORK Slack Technologies
$29.73 /

+0.16 (+0.54%)

CRM Salesforce
$263.72 /

+3.01 (+1.15%)

WORK Slack Technologies
$29.73 /

+0.16 (+0.54%)

CRM Salesforce
$263.72 /

+3.01 (+1.15%)

Conference/Events
Radiant Logistics management to meet virtually with Loop Capital » 11:39
11/25/20
11/25
11:39
11/25/20
11:39
RLGT

Radiant Logistics

$5.94 /

-0.02 (-0.34%)

Virtual Meeting to be…

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RLGT Radiant Logistics
$5.94 /

-0.02 (-0.34%)

RLGT Radiant Logistics
$5.94 /

-0.02 (-0.34%)

05/12/20 Lake Street
Radiant Logistics price target lowered to $7 from $9 at Lake Street
02/28/20 Benchmark
Radiant Logistics initiated with a Buy at Benchmark
RLGT Radiant Logistics
$5.94 /

-0.02 (-0.34%)

RLGT Radiant Logistics
$5.94 /

-0.02 (-0.34%)

Periodicals
Salesforce has held talks to acquire Slack Technologies, WSJ reports  11:39
11/25/20
11/25
11:39
11/25/20
11:39
WORK

Slack Technologies

$29.77 /

+0.2 (+0.68%)

, CRM

Salesforce

$263.92 /

+3.21 (+1.23%)

 
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WORK Slack Technologies
$29.77 /

+0.2 (+0.68%)

CRM Salesforce
$263.92 /

+3.21 (+1.23%)

WORK Slack Technologies
$29.77 /

+0.2 (+0.68%)

11/23/20 KeyBanc
Slack Technologies initiated with a Sector Weight at KeyBanc
11/23/20 KeyBanc
Slack Technologies initiated with a Sector Weight at KeyBanc
10/23/20 Barclays
Slack Technologies price target raised to $36 from $31 at Barclays
10/21/20
Fly Intel: Top five analyst downgrades
CRM Salesforce
$263.92 /

+3.21 (+1.23%)

09:19 Today BMO Capital
Salesforce price target raised to $285 from $260 at BMO Capital
11/23/20 KeyBanc
Salesforce initiated with an Overweight at KeyBanc
11/23/20 KeyBanc
Salesforce initiated with an Overweight at KeyBanc
11/22/20 Jefferies
Salesforce price target raised to $320 from $285 at Jefferies
WORK Slack Technologies
$29.77 /

+0.2 (+0.68%)

CRM Salesforce
$263.92 /

+3.21 (+1.23%)

WORK Slack Technologies
$29.77 /

+0.2 (+0.68%)

CRM Salesforce
$263.92 /

+3.21 (+1.23%)

WORK Slack Technologies
$29.77 /

+0.2 (+0.68%)

CRM Salesforce
$263.92 /

+3.21 (+1.23%)

WORK Slack Technologies
$29.77 /

+0.2 (+0.68%)

CRM Salesforce
$263.92 /

+3.21 (+1.23%)

Recommendations
Arcelik price target raised to TRY 34.50 from TRY 32.70 at JPMorgan » 11:38
11/25/20
11/25
11:38
11/25/20
11:38
ACKAY

Arcelik

$0.00 /

+ (+0.00%)

JPMorgan analyst Hanzade…

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ACKAY Arcelik
$0.00 /

+ (+0.00%)

ACKAY Arcelik
$0.00 /

+ (+0.00%)

10/26/20 JPMorgan
Arcelik price target raised to TRY 32.70 from TRY 31 at JPMorgan
10/12/20 JPMorgan
Arcelik upgraded to Overweight from Neutral at JPMorgan
07/28/20 HSBC
Arcelik upgraded to Buy from Hold at HSBC
07/13/20 JPMorgan
Arcelik price target raised to TRY 19.90 from TRY 18.37 at JPMorgan
Recommendations
AO World price target raised to 225 GBp from 190 GBp at JPMorgan » 11:37
11/25/20
11/25
11:37
11/25/20
11:37
AOWDF

AO World

$0.00 /

+ (+0.00%)

JPMorgan analyst Georgina…

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AOWDF AO World
$0.00 /

+ (+0.00%)

10/20/20 JPMorgan
AO World price target raised to 190 GBp from 120 GBp at JPMorgan
07/15/20 Jefferies
AO World price target raised to 195 GBp from 165 GBp at Jefferies
05/28/20 Jefferies
AO World upgraded to Buy from Hold at Jefferies
05/13/20 JPMorgan
AO World price target raised to 101 GBp from 93 GBp at JPMorgan
Recommendations
Akbank price target raised to TRY 10.50 from TRY 8.40 at JPMorgan » 11:35
11/25/20
11/25
11:35
11/25/20
11:35
AKBTY

Akbank

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+ (+0.00%)

JPMorgan analyst Samuel…

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AKBTY Akbank
$0.00 /

+ (+0.00%)

09/22/20 JPMorgan
Akbank price target lowered to TRY 8.40 from TRY 9.20 at JPMorgan
07/16/20 JPMorgan
Akbank price target raised to TRY 9.20 from TRY 8.20 at JPMorgan
06/16/20 Societe Generale
Akbank upgraded to Buy from Hold at Societe Generale
05/22/20 JPMorgan
Akbank price target raised to TRY 8.20 from TRY 7.90 at JPMorgan
Options
Barclays put volume heavy and directionally bearish » 11:35
11/25/20
11/25
11:35
11/25/20
11:35
BCS

Barclays

$7.65 /

-0.365 (-4.55%)

Bearish flow noted in…

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BCS Barclays
$7.65 /

-0.365 (-4.55%)

BCS Barclays
$7.65 /

-0.365 (-4.55%)

11/24/20 Morgan Stanley
Barclays price target raised to 145 GBp from 130 GBp at Morgan Stanley
11/10/20 AlphaValue
Barclays upgraded to Add from Reduce at AlphaValue
11/10/20 Investec
Barclays downgraded to Hold from Buy at Investec
10/26/20 Morgan Stanley
Barclays price target raised to 130 GBp from 120 GBp at Morgan Stanley
BCS Barclays
$7.65 /

-0.365 (-4.55%)

BCS Barclays
$7.65 /

-0.365 (-4.55%)

BCS Barclays
$7.65 /

-0.365 (-4.55%)

BCS Barclays
$7.65 /

-0.365 (-4.55%)

General news
The U.S. advance indicators report » 11:30
11/25/20
11/25
11:30
11/25/20
11:30

The U.S. advance…

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Recommendations
H.C. Wainwright keeps Buy rating on Revance, says FDA news 'not surprising' » 11:28
11/25/20
11/25
11:28
11/25/20
11:28
RVNC

Revance

$24.28 /

+0.92 (+3.94%)

H.C. Wainwright analyst…

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RVNC Revance
$24.28 /

+0.92 (+3.94%)

RVNC Revance
$24.28 /

+0.92 (+3.94%)

11/10/20 Mizuho
Revance price target lowered to $30 from $32 at Mizuho
10/26/20 Barclays
Revance price target raised to $38 from $35 at Barclays
10/15/20 H.C. Wainwright
Revance price target raised to $33 from $27 at H.C. Wainwright
09/28/20 Barclays
Revance price target raised to $35 from $32 at Barclays
RVNC Revance
$24.28 /

+0.92 (+3.94%)

  • 04
    Dec
RVNC Revance
$24.28 /

+0.92 (+3.94%)

Conference/Events
Element Solutions management to meet virtually with Loop Capital » 11:28
11/25/20
11/25
11:28
11/25/20
11:28
ESI

Element Solutions

$13.96 /

-0.32 (-2.24%)

Virtual Meeting to be…

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ESI Element Solutions
$13.96 /

-0.32 (-2.24%)

ESI Element Solutions
$13.96 /

-0.32 (-2.24%)

10/12/20 Loop Capital
Element Solutions initiated with a Buy at Loop Capital
04/20/20 SunTrust
Element Solutions upgraded to Buy from Hold at SunTrust
ESI Element Solutions
$13.96 /

-0.32 (-2.24%)

ESI Element Solutions
$13.96 /

-0.32 (-2.24%)

ESI Element Solutions
$13.96 /

-0.32 (-2.24%)

Recommendations
Endeavour Mining price target raised to C$56 from C$51 at Berenberg » 11:25
11/25/20
11/25
11:25
11/25/20
11:25
EDVMF

Endeavour Mining

$0.00 /

+ (+0.00%)

Berenberg analyst Richard…

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EDVMF Endeavour Mining
$0.00 /

+ (+0.00%)

EDVMF Endeavour Mining
$0.00 /

+ (+0.00%)

11/19/20 RBC Capital
Endeavour Mining price target raised to C$51 from C$50 at RBC Capital
11/16/20 BMO Capital
Endeavour Mining price target lowered to C$46 from C$48 at BMO Capital
11/11/20 RBC Capital
Endeavour Mining price target raised to C$50 from C$47 at RBC Capital
10/22/20 National Bank
Endeavour Mining price target raised to C$60 from C$56 at National Bank
Options
Chegg call volume above normal and directionally bullish » 11:25
11/25/20
11/25
11:25
11/25/20
11:25
CHGG

Chegg

$71.20 /

+2.47 (+3.59%)

Bullish option flow…

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CHGG Chegg
$71.20 /

+2.47 (+3.59%)

CHGG Chegg
$71.20 /

+2.47 (+3.59%)

11/06/20
Fly Intel: Top five analyst initiations
11/06/20 Exane BNP Paribas
Chegg initiated with an Underperform at Exane BNP Paribas
10/27/20 Lake Street
Chegg price target raised to $85 from $79 at Lake Street
10/20/20 Morgan Stanley
Morgan Stanley sees more upside as likely for Chegg
CHGG Chegg
$71.20 /

+2.47 (+3.59%)

CHGG Chegg
$71.20 /

+2.47 (+3.59%)

CHGG Chegg
$71.20 /

+2.47 (+3.59%)

CHGG Chegg
$71.20 /

+2.47 (+3.59%)

Conference/Events
Sunnova Energy participates in a webinar with Roth Capital » 11:23
11/25/20
11/25
11:23
11/25/20
11:23
NOVA

Sunnova Energy

$41.65 /

+1.83 (+4.60%)

Sustainability Analyst…

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NOVA Sunnova Energy
$41.65 /

+1.83 (+4.60%)

NOVA Sunnova Energy
$41.65 /

+1.83 (+4.60%)

11/09/20 Goldman Sachs
Sunnova Energy upgraded to Conviction Buy from Buy at Goldman Sachs
10/27/20 B. Riley Securities
Sunnova Energy price target raised to $33 from $30 at B. Riley Securities
10/26/20 Credit Suisse
Sunnova Energy price target raised to $38 from $26 at Credit Suisse
10/22/20 Baird
Baird a buyer of solar stocks insulated from supply chain disruptions
NOVA Sunnova Energy
$41.65 /

+1.83 (+4.60%)

  • 14
    Aug
  • 01
    Jul
NOVA Sunnova Energy
$41.65 /

+1.83 (+4.60%)

NOVA Sunnova Energy
$41.65 /

+1.83 (+4.60%)

Recommendations
Pets at Home Group price target raised to 480 GBp from 450 GBp at Berenberg » 11:23
11/25/20
11/25
11:23
11/25/20
11:23
PAHGF

Pets at Home Group

$0.00 /

+ (+0.00%)

Berenberg analyst Owen…

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PAHGF Pets at Home Group
$0.00 /

+ (+0.00%)

10/13/20 Citi
Pets at Home Group price target raised to 460 GBp from 355 GBp at Citi
08/06/20 Berenberg
Pets at Home Group price target raised to 350 GBp from 300 GBp at Berenberg
08/03/20 Morgan Stanley
Pets at Home Group price target raised to 210 GBp from 190 GBp at Morgan Stanley
06/24/20 Citi
Pets at Home Group upgraded to Buy from Neutral at Citi
Technical Analysis
NASDAQ market internals summary » 11:17
11/25/20
11/25
11:17
11/25/20
11:17
$NSD

NASDAQ Market Internals

$0.00 /

+ (+0.00%)

Volume is above average…

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$NSD NASDAQ Market Internals
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Technical Analysis
NYSE market internals summary » 11:16
11/25/20
11/25
11:16
11/25/20
11:16
$NYE

NYSE Market Internals

$0.00 /

+ (+0.00%)

Volume is above average…

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$NYE NYSE Market Internals
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General news
FX Action: USD-CAD » 11:15
11/25/20
11/25
11:15
11/25/20
11:15

FX Action: USD-CAD…

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General news
The U.S. durable goods report sharply exceeded estimates » 11:15
11/25/20
11/25
11:15
11/25/20
11:15

The U.S. durable goods…

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General news
Treasury Action: yields remain a little richer on the session » 11:15
11/25/20
11/25
11:15
11/25/20
11:15

Treasury Action: yields…

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General news
4-Week Bill Auction to be released at 11:30  11:15
11/25/20
11/25
11:15
11/25/20
11:15
 
General news
8-Week Bill Auction to be released at 11:30  11:15
11/25/20
11/25
11:15
11/25/20
11:15
 
General news
8-Week Bill Auction to be released at 11:30  11:15
11/25/20
11/25
11:15
11/25/20
11:15
 
General news
4-Week Bill Auction to be released at 11:30  11:15
11/25/20
11/25
11:15
11/25/20
11:15
 
Recommendations
Fraport price target lowered to EUR 54 from EUR 74 at Morgan Stanley » 11:13
11/25/20
11/25
11:13
11/25/20
11:13
FPRUY

Fraport

$0.00 /

+ (+0.00%)

Morgan Stanley analyst…

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FPRUY Fraport
$0.00 /

+ (+0.00%)

11/13/20 JPMorgan
Fraport upgraded to Neutral from Underweight at JPMorgan
11/05/20 Barclays
Fraport price target lowered to EUR 32 from EUR 35 at Barclays
09/17/20 Berenberg
Fraport upgraded to Buy from Hold at Berenberg
08/28/20 Deutsche Bank
Fraport downgraded to Hold from Buy at Deutsche Bank

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