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CCCC

C4 Therapeutics

$38.00 /

+0.8 (+2.15%)

08:22
06/21/21
06/21
08:22
06/21/21
08:22

C4 Therapeutics presents preclinical data on CFT7455

C4 Therapeutics presented pre-clinical data for CFT7455, the Company's lead program. CFT7455 is an orally bioavailable MonoDAC targeting IKZF1/3 for the treatment of multiple myeloma and non-Hodgkin's lymphomas, including peripheral T-cell lymphoma and mantle cell lymphoma. These results, which support clinical evaluation of CFT7455 in non-Hodgkin's lymphomas, were delivered as a poster presentation at the 16th Annual International Conference on Malignant Lymphoma. C4T conducted in vitro studies which demonstrated that CFT7455 binds to cereblon with high affinity, inducing potent and deep degradation of IKZF1 in pre-clinical NHL models. Notable observations include: Cellular competition studies confirmed the high potency of CFT7455 as a cereblon binder. Treatment of the KiJK cell line of anaplastic large cell lymphoma with CFT7455 for 6 hours led to an 89% reduction in IKZF1 protein levels. CFT7455 demonstrated potent antiproliferative activity across a panel of NHL cell lines with MYC, BCL2, and/or BCL6 translocations or rearrangements. This includes in vitro models of cutaneous T-cell lymphoma, anaplastic large cell lymphoma, mantle cell lymphoma, and high-grade B-cell lymphoma. In xenograft models of NHL, CFT7455 achieved improved in vivo potency and efficacy, including deeper and more durable tumor regressions in models of ALCL, diffuse large B-cell lymphoma and MCL, when compared to approved and investigational IMiD therapies. Notable observations include: CFT7455 treatment led to durable tumor regression associated with deep IKZF1 degradation and IRF4 downregulation in KiJK xenografts, where pomalidomide treatment was ineffective at a clinically relevant dose. In the TMD8 DLBCL xenograft model, which proved insensitive to IMiD treatment, CFT7455 promoted tumor regression. In the REC1 MCL xenograft model, doses of CFT7455 greater than or equal to 10 microgram/kg promoted tumor regression. Pharmacodynamic studies showed that CFT7455 promoted degradation of IKZF1 and downregulation of cyclin D1 and E2F1. CFT7455 achieved dose-dependent efficacy in both ALK- and ALK+ xenograft models, from 3-100 microgram/kg with regressions at doses greater than or equal to 30 microgram/kg. In addition, CFT7455 was shown to be between greater than30-100 times more potent than other IKZF1/3 degraders in development. Global proteomic studies showed only IKZF1/3 proteins were significantly degraded in DL-40 tumors with treatment of CFT7455, resulting in modulation of IFN-regulated genes. These results support continued development of CFT7455, which C4T is currently exploring for the treatment of relapsed or refractory multiple myeloma and non-Hodgkin's lymphomas following the initiation of a Phase 1/2 clinical study in June 2021.

  • 02

    Oct

  • 17

    Jun

CCCC C4 Therapeutics
$38.00 /

+0.8 (+2.15%)

06/04/21 H.C. Wainwright
C4 Therapeutics initiated with a Buy at H.C. Wainwright
03/31/21 BMO Capital
C4 Therapeutics initiated with an Outperform at BMO Capital
12/08/20 BMO Capital
C4 Therapeutics price target raised to $45 from $33 at BMO Capital
11/24/20 Morgan Stanley
Kymera Therapeutics price target raised to $45 from $27 at Morgan Stanley

TODAY'S FREE FLY STORIES

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Recommendations
TCR2 Therapeutics price target lowered to $25 from $37 at H.C. Wainwright » 06:23
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  • 20
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Upgrade
Credit Suisse upgrades 'compelling' Acadia Healthcare on recent selloff » 06:21
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06:06 Today Credit Suisse
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Downgrade
Itamar Medical downgraded to Market Perform from Outperform at SVB Leerink » 06:18
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SVB Leerink analyst…

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  • 05
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Initiation
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$17.23 /

+0.385 (+2.29%)

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Downgrade
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Periodicals
Facebook leaders worry whether platform has gotten 'too big,' WSJ reports » 06:14
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FB Facebook
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Initiation
FinTech Acquisition Corp. V initiated with a Neutral at Compass Point » 06:12
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FTCV

FinTech Acquisition Corp. V

$10.26 /

-0.02 (-0.19%)

Compass Point analyst…

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FTCV FinTech Acquisition Corp. V
$10.26 /

-0.02 (-0.19%)

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Recommendations
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PTGX

Protagonist Therapeutics

$17.60 /

-28.53 (-61.85%)

H.C. Wainwright analyst…

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PTGX Protagonist Therapeutics
$17.60 /

-28.53 (-61.85%)

PTGX Protagonist Therapeutics
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Protagonist clinical hold brings more questions than answers, says Piper Sandler
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Protagonist Therapeutics price target raised to $60 from $50 at H.C. Wainwright
PTGX Protagonist Therapeutics
$17.60 /

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  • 16
    Jun
  • 11
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PTGX Protagonist Therapeutics
$17.60 /

-28.53 (-61.85%)

Recommendations
Sprout Social price target raised to $150 from $110 at BTIG » 06:11
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SPT

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$136.95 /

+1.66 (+1.23%)

BTIG analyst Matt…

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SPT Sprout Social
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$136.95 /

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Downgrade
Top Glove downgraded to Sell from Neutral at Citi » 06:09
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TGLVY

Top Glove

$3.19 /

-0.01 (-0.31%)

Citi analyst Megat Fais…

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TGLVY Top Glove
$3.19 /

-0.01 (-0.31%)

05/19/21 Credit Suisse
Top Glove upgraded to Outperform from Neutral at Credit Suisse
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Top Glove downgraded to Neutral from Outperform at Credit Suisse
Upgrade
Teradata upgraded to Overweight from Equal Weight at Morgan Stanley » 06:08
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$50.60 /

-0.67 (-1.31%)

Morgan Stanley analyst…

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TDC Teradata
$50.60 /

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09/10/21 JMP Securities
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Stifel says Parker-Hannifin's Meggitt bid has 'smoother route' with Teradata out
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Hot Stocks
OraSure receives $205M procurement contract for InteliSwab » 06:07
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+1.945 (+17.04%)

OraSure Technologies…

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Upgrade
Acadia Healthcare upgraded to Outperform from Neutral at Credit Suisse » 06:06
09/20/21
09/20
06:06
09/20/21
06:06
ACHC

Acadia Healthcare

$61.18 /

+1.87 (+3.15%)

Credit Suisse analyst…

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ACHC Acadia Healthcare
$61.18 /

+1.87 (+3.15%)

ACHC Acadia Healthcare
$61.18 /

+1.87 (+3.15%)

09/09/21 Cowen
Acadia Healthcare organic growth accelerating, says Cowen
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Acadia Healthcare price target raised to $68 from $60 at Credit Suisse
ACHC Acadia Healthcare
$61.18 /

+1.87 (+3.15%)

Hot Stocks
Moxian appoints Conglin Deng as CEO » 06:05
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Moxian

$7.32 /

+0.56 (+8.28%)

Moxian announced that it…

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Initiation
Clarus Therapeutics initiated with an Overweight at Cantor Fitzgerald » 06:05
09/20/21
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06:05
09/20/21
06:05
CRXT

Clarus Therapeutics

/

+

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CRXT Clarus Therapeutics
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National Bank upgraded to Overweight from Neutral at Piper Sandler » 06:05
09/20/21
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06:05
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NBHC

National Bank

$35.96 /

+1.06 (+3.04%)

Piper Sandler analyst…

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NBHC National Bank
$35.96 /

+1.06 (+3.04%)

NBHC National Bank
$35.96 /

+1.06 (+3.04%)

06/30/21 DA Davidson
National Bank upgraded to Buy at DA Davidson on above-peer growth profile
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NBHC National Bank
$35.96 /

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Hot Stocks
Amazon, Global Optimism announce 86 new signatories to The Climate Pledge » 06:04
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AMZN

Amazon.com

$3,461.96 /

-25.76 (-0.74%)

, PG

Procter & Gamble

$144.34 /

+0.22 (+0.15%)

, HPQ

HP Inc.

$27.68 /

-0.37 (-1.32%)

, CRM

Salesforce

$260.52 /

+0.13 (+0.05%)

, ASOMY

Asos

$43.78 /

+1.63 (+3.87%)

Amazon (AMZN) and Global…

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AMZN Amazon.com
$3,461.96 /

-25.76 (-0.74%)

PG Procter & Gamble
$144.34 /

+0.22 (+0.15%)

HPQ HP Inc.
$27.68 /

-0.37 (-1.32%)

CRM Salesforce
$260.52 /

+0.13 (+0.05%)

AMZN Amazon.com
$3,461.96 /

-25.76 (-0.74%)

09/14/21 Evercore ISI
Amazon price target raised to $4,700 from $4,200 at Evercore ISI
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Amazon.com initiated with a Buy at Goldman Sachs
09/10/21 BofA
Affirm price target raised to $119 from $82 at BofA
PG Procter & Gamble
$144.34 /

+0.22 (+0.15%)

05:05 Today Deutsche Bank
Colgate-Palmolive upgraded to Buy from Hold at Deutsche Bank
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Procter & Gamble called top household products pick at Morgan Stanley
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Procter & Gamble upgraded to Buy from Hold at Erste Group
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Procter & Gamble price target raised to $145 from $140 at Truist
HPQ HP Inc.
$27.68 /

-0.37 (-1.32%)

08/27/21
Fly Intel: Top five analyst downgrades
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Morgan Stanley prefers Dell to HP, ups price target to $133
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HP Inc. downgraded to Equal Weight from Overweight at Morgan Stanley
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CRM Salesforce
$260.52 /

+0.13 (+0.05%)

09/17/21 Barclays
Salesforce price target raised to $330 from $320 at Barclays
08/27/21 Loop Capital
Salesforce price target raised to $265 from $235 at Loop Capital
08/27/21 Societe Generale
Salesforce price target raised to $321 from $290 at Societe Generale
08/26/21 RBC Capital
Salesforce assumed with an Outperform at RBC Capital
ASOMY Asos
$43.78 /

+1.63 (+3.87%)

09/08/21 Exane BNP Paribas
Asos downgraded to Neutral from Outperform at Exane BNP Paribas
09/07/21 Berenberg
Asos price target lowered to 6,500 GBp from 6,700 GBp at Berenberg
09/03/21 JPMorgan
Asos price target lowered to 6,680 GBp from 6,800 GBp at JPMorgan
08/25/21 Deutsche Bank
Asos initiated with a Buy at Deutsche Bank
AMZN Amazon.com
$3,461.96 /

-25.76 (-0.74%)

PG Procter & Gamble
$144.34 /

+0.22 (+0.15%)

HPQ HP Inc.
$27.68 /

-0.37 (-1.32%)

CRM Salesforce
$260.52 /

+0.13 (+0.05%)

AMZN Amazon.com
$3,461.96 /

-25.76 (-0.74%)

PG Procter & Gamble
$144.34 /

+0.22 (+0.15%)

HPQ HP Inc.
$27.68 /

-0.37 (-1.32%)

CRM Salesforce
$260.52 /

+0.13 (+0.05%)

AMZN Amazon.com
$3,461.96 /

-25.76 (-0.74%)

PG Procter & Gamble
$144.34 /

+0.22 (+0.15%)

HPQ HP Inc.
$27.68 /

-0.37 (-1.32%)

CRM Salesforce
$260.52 /

+0.13 (+0.05%)

AMZN Amazon.com
$3,461.96 /

-25.76 (-0.74%)

PG Procter & Gamble
$144.34 /

+0.22 (+0.15%)

HPQ HP Inc.
$27.68 /

-0.37 (-1.32%)

CRM Salesforce
$260.52 /

+0.13 (+0.05%)

Recommendations
Nike supply chain disruptions creates buying opportunity, says Piper Sandler » 06:03
09/20/21
09/20
06:03
09/20/21
06:03
NKE

Nike

$156.41 /

-1.21 (-0.77%)

Piper Sandler analyst…

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NKE Nike
$156.41 /

-1.21 (-0.77%)

NKE Nike
$156.41 /

-1.21 (-0.77%)

09/13/21
Fly Intel: Top five analyst downgrades
09/13/21 BTIG
BTIG downgrades Nike on 'severe supply chain disruptions' in Vietnam
09/13/21 BTIG
Nike downgraded to Neutral from Buy at BTIG
09/09/21 UBS
Nike more likely to rise than fall after Q1 results, says UBS
NKE Nike
$156.41 /

-1.21 (-0.77%)

NKE Nike
$156.41 /

-1.21 (-0.77%)

NKE Nike
$156.41 /

-1.21 (-0.77%)

NKE Nike
$156.41 /

-1.21 (-0.77%)

Initiation
PAE initiated with a Buy at BofA » 06:03
09/20/21
09/20
06:03
09/20/21
06:03
PAE

PAE

$5.90 /

+0.045 (+0.77%)

BofA initiated coverage…

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PAE PAE
$5.90 /

+0.045 (+0.77%)

PAE PAE
$5.90 /

+0.045 (+0.77%)

08/25/21
Fly Intel: Top five analyst downgrades
08/25/21 Morgan Stanley
PAE downgraded to Equal Weight from Overweight at Morgan Stanley
08/25/21 Morgan Stanley
PAE downgraded to Equal Weight from Overweight at Morgan Stanley
03/17/21 Deutsche Bank
PAE downgraded on 'unexpected' CEO change at Deutsche Bank
PAE PAE
$5.90 /

+0.045 (+0.77%)

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