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CRL

Charles River

$403.61 /

-2.325 (-0.57%)

09:11
10/18/21
10/18
09:11
10/18/21
09:11

Charles River, ATEM in pact to provide clients with cryo-EM capabilities

Charles River Laboratories International and ATEM Structural Discovery announced the formation of a strategic partnership to provide clients access to ATEM's cryo-electron microscopy cryo-EM service solutions. Cryo-EM is a technique that determines the 3D structures of proteins and is utilized to identify how proteins function, how they malfunction in disease and the most effective way to target them with therapies. ATEM's leading platform integrates highly optimized biochemistry, hardware, and software to provide in-depth structural insights about challenging targets at a commercial scale. ATEM's technology directly images vitrified biological macromolecules in single-particle experiments at high resolution. Subsequently, reconstructed coulomb potential maps then allow the precise modeling of 3D atomic coordinates that elucidate the target structure. T By combining ATEM's cryo-EM expertise with Charles River's end-to-end capabilities, the alliance has the potential to significantly accelerate drug discovery efforts from hit design through to lead optimization. With early insights into how lead candidates interact with their intended disease target, clients can interpret actual structural changes, allowing more informed prioritization and optimization of lead candidates. Through the collaboration, Charles River clients will have access to ATEM's platform to support their drug discovery efforts. When utilizing ATEM's cryo-EM platform, clients will be provided with enhanced insights into challenging targets by viewing the 3D structure of full biochemical assemblies, ligand-bound complexes and biologic drugs. This partnership allows Charles River to enhance drug discovery projects by enabling structure-based design for a greater portfolio of targets.

  • 03

    Nov

  • 08

    Nov

CRL Charles River
$403.61 /

-2.325 (-0.57%)

08/23/21 Argus
Charles River price target raised to $480 from $390 at Argus
08/17/21 UBS
Charles River price target raised to $465 from $390 at UBS
08/05/21 Credit Suisse
Charles River price target raised to $420 from $385 at Credit Suisse
08/05/21 Wells Fargo
Charles River price target raised to $470 from $375 at Wells Fargo

TODAY'S FREE FLY STORIES

Recommendations
Vertex Phase 2 data an 'incremental positive,' says Piper Sandler » 10:42
12/01/21
12/01
10:42
12/01/21
10:42
VRTX

Vertex Pharmaceuticals

$197.64 /

+10.65 (+5.70%)

Piper Sandler analyst Do…

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VRTX Vertex Pharmaceuticals
$197.64 /

+10.65 (+5.70%)

VRTX Vertex Pharmaceuticals
$197.64 /

+10.65 (+5.70%)

11/18/21 BMO Capital
Vertex Pharmaceuticals initiated with a Market Perform at BMO Capital
11/18/21 Piper Sandler
Vertex downgraded to Neutral at Piper ahead of AbbVie CF data
11/18/21 Piper Sandler
Vertex Pharmaceuticals downgraded to Neutral from Overweight at Piper Sandler
11/08/21 Goldman Sachs
Bluebird Bio downgraded to Sell from Neutral at Goldman Sachs
VRTX Vertex Pharmaceuticals
$197.64 /

+10.65 (+5.70%)

VRTX Vertex Pharmaceuticals
$197.64 /

+10.65 (+5.70%)

VRTX Vertex Pharmaceuticals
$197.64 /

+10.65 (+5.70%)

Downgrade
BeyondSpring downgraded to Market Perform from Outperform at William Blair » 10:41
12/01/21
12/01
10:41
12/01/21
10:41
BYSI

BeyondSpring

$6.17 /

-6.595 (-51.68%)

William Blair analyst…

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BYSI BeyondSpring
$6.17 /

-6.595 (-51.68%)

BYSI BeyondSpring
$6.17 /

-6.595 (-51.68%)

09:36 Today H.C. Wainwright
BeyondSpring downgraded to Neutral at H.C. Wainwright after CRL for plinabulin
09:33 Today H.C. Wainwright
BeyondSpring downgraded to Neutral from Buy at H.C. Wainwright
09/20/21 H.C. Wainwright
BeyondSpring price target lowered to $65 from $100 at H.C. Wainwright
09/08/21 Baird
BeyondSpring initiated with an Outperform at Baird
BYSI BeyondSpring
$6.17 /

-6.595 (-51.68%)

BYSI BeyondSpring
$6.17 /

-6.595 (-51.68%)

BYSI BeyondSpring
$6.17 /

-6.595 (-51.68%)

Syndicate
Capitalworks Emerging Markets Acquisition opens at $10.07, priced at $10/unit » 10:40
12/01/21
12/01
10:40
12/01/21
10:40
CMCA

Capitalworks Emerging Markets Acquisition

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General news
The U.S. ISM nearly matched estimates » 10:40
12/01/21
12/01
10:40
12/01/21
10:40
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Economic Data

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Syndicate
TLGY Acquisition opens at $10.08, IPO priced at $10 per unit » 10:32
12/01/21
12/01
10:32
12/01/21
10:32
TLGY

TLGY Acquisition

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General news
Week of 11/26 distillate inventories up 2.2M barrels  10:32
12/01/21
12/01
10:32
12/01/21
10:32
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General news
Week of 11/26 gasoline inventories up 4.0M barrels  10:32
12/01/21
12/01
10:32
12/01/21
10:32
$ECON

Economic Data

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General news
Week of 11/26 crude oil inventories down 0.9M barrels  10:32
12/01/21
12/01
10:32
12/01/21
10:32
$ECON

Economic Data

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Periodicals
Byron Allen's $10B McDonald's discrimination suit thrown out, Reuters says » 10:31
12/01/21
12/01
10:31
12/01/21
10:31
MCD

McDonald's

$249.25 /

+4.73 (+1.93%)

A U.S. judge has…

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MCD McDonald's
$249.25 /

+4.73 (+1.93%)

MCD McDonald's
$249.25 /

+4.73 (+1.93%)

11/16/21 Argus
Wendy's downgraded to Hold at Argus after miss on Q3 comps and margins
10/28/21 Credit Suisse
McDonald's price target raised to $281 from $271 at Credit Suisse
10/28/21 Oppenheimer
McDonald's price target raised to $280 from $270 at Oppenheimer
10/28/21 JPMorgan
McDonald's price target raised to $260 from $250 at JPMorgan
MCD McDonald's
$249.25 /

+4.73 (+1.93%)

MCD McDonald's
$249.25 /

+4.73 (+1.93%)

MCD McDonald's
$249.25 /

+4.73 (+1.93%)

MCD McDonald's
$249.25 /

+4.73 (+1.93%)

General news
Crude inventories for week of November 26 » 10:30
12/01/21
12/01
10:30
12/01/21
10:30
USO

United States Oil Fund

$49.06 /

+1.17 (+2.44%)

Crude oil inventories…

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USO United States Oil Fund
$49.06 /

+1.17 (+2.44%)

USO United States Oil Fund
$49.06 /

+1.17 (+2.44%)

Technical Analysis
DJ Transportation Average: Pivot points » 10:30
12/01/21
12/01
10:30
12/01/21
10:30
$DJT

DJ Transportation Average

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General news
U.S. construction spending bounced 0.2% in October » 10:30
12/01/21
12/01
10:30
12/01/21
10:30
$ECON

Economic Data

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U.S. construction…

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General news
Wall Street is sharply higher in early trade » 10:30
12/01/21
12/01
10:30
12/01/21
10:30
$ECON

Economic Data

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Periodicals
Toyota reports November U.S. sales down 25.4% to 153,593 units, Bloomberg says  10:25
12/01/21
12/01
10:25
12/01/21
10:25
TM

Toyota

$182.74 /

+5.01 (+2.82%)

 
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TM Toyota
$182.74 /

+5.01 (+2.82%)

TM Toyota
$182.74 /

+5.01 (+2.82%)

11/02/21 Nomura
Nomura downgrades Ford to Reduce, calls premium valuation 'hard to justify'
10/18/21 Bernstein
Bernstein still 'struggles' with Tesla stock valuation
10/12/21 Morgan Stanley
Toyota initiated with an Overweight at Morgan Stanley
09/16/21 Morgan Stanley
XPeng 'aiming to redefine mass-market EVs' with P5, says Morgan Stanley
TM Toyota
$182.74 /

+5.01 (+2.82%)

TM Toyota
$182.74 /

+5.01 (+2.82%)

TM Toyota
$182.74 /

+5.01 (+2.82%)

Options
PLBY Group call volume above normal and directionally bullish » 10:25
12/01/21
12/01
10:25
12/01/21
10:25
PLBY

PLBY Group

$40.98 /

+2.505 (+6.51%)

Bullish option flow…

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PLBY PLBY Group
$40.98 /

+2.505 (+6.51%)

PLBY PLBY Group
$40.98 /

+2.505 (+6.51%)

11/23/21 Chardan
PLBY Group initiated with a Buy at Chardan
11/16/21 Loop Capital
PLBY Group price target raised to $50 from $29 at Loop Capital
09/30/21 Loop Capital
PLBY Group initiated with a Buy at Loop Capital
08/11/21 Roth Capital
PLBY Group price target lowered to $45 from $55 at Roth Capital
PLBY PLBY Group
$40.98 /

+2.505 (+6.51%)

  • 10
    Jun
PLBY PLBY Group
$40.98 /

+2.505 (+6.51%)

PLBY PLBY Group
$40.98 /

+2.505 (+6.51%)

PLBY PLBY Group
$40.98 /

+2.505 (+6.51%)

Conference/Events
Lava Therapeutics participates in a conference call with JPMorgan » 10:25
12/01/21
12/01
10:25
12/01/21
10:25
LVTX

Lava Therapeutics

$6.94 /

+ (+0.00%)

SMid Cap Biotech Analyst…

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LVTX Lava Therapeutics
$6.94 /

+ (+0.00%)

LVTX Lava Therapeutics
$6.94 /

+ (+0.00%)

04/19/21 SVB Leerink
SVB Leerink bullish on Lava Therapeutics, initiates with an Outperform
04/19/21 JPMorgan
Lava Therapeutics initiated with an Overweight at JPMorgan
04/19/21 Jefferies
Lava Therapeutics initiated with a Buy at Jefferies
04/19/21 SVB Leerink
Lava Therapeutics initiated with an Outperform at SVB Leerink
LVTX Lava Therapeutics
$6.94 /

+ (+0.00%)

  • 25
    Mar
Conference/Events
Cowen ESG & restaurant analysts hold analyst/industry conference call » 10:25
12/01/21
12/01
10:25
12/01/21
10:25

ESG Policy Analyst Miller…

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Conference/Events
Argus research director to hold an analyst/industry conference call » 10:25
12/01/21
12/01
10:25
12/01/21
10:25

Research Director…

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Technical Analysis
DJ Utility Average: Pivot points » 10:23
12/01/21
12/01
10:23
12/01/21
10:23
$DJU

DJ Utility Average

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Technical Analysis
NASDAQ market internals summary » 10:23
12/01/21
12/01
10:23
12/01/21
10:23
$NSD

NASDAQ Market Internals

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Technical Analysis
NYSE market internals summary » 10:22
12/01/21
12/01
10:22
12/01/21
10:22
$NYE

NYSE Market Internals

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Hot Stocks
Wunong Net announces name change to Meiwu Technology Company » 10:17
12/01/21
12/01
10:17
12/01/21
10:17
WNW

Wunong Net Technology

$3.05 /

+0.06 (+2.01%)

Wunong Net Technology…

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  • 15
    Dec
Technical Analysis
Dow Jones Industrial Average: Pivot points » 10:16
12/01/21
12/01
10:16
12/01/21
10:16
DJX

Dow Jones Industrial Average

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11/26/21 Morgan Stanley
Covid variant mutations may reduce vaccine effectiveness, says Morgan Stanley
11/26/21 Credit Suisse
Concerns over new Covid variant 'understandable,' says Credit Suisse
DJX Dow Jones Industrial Average
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DJX Dow Jones Industrial Average
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General news
October construction spending up 8.6% vs. last year  10:15
12/01/21
12/01
10:15
12/01/21
10:15
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General news
FX Action: The dollar » 10:15
12/01/21
12/01
10:15
12/01/21
10:15
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Economic Data

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FX Action: The dollar…

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