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RDUS

Radius Health

$8.62 /

-5.72 (-39.89%)

10:20
12/08/21
12/08
10:20
12/08/21
10:20

Radius Health says EMERALD trial meets both primary endpoints

The Menarini Group and Radius Health provided details on the elacestrant data from the EMERALD trial following the positive results presented today at the San Antonio Breast Cancer Symposium. The data was presented as a "Late Breaker" and shared in an oral presentation by Dr. Aditya Bardia, MD. The EMERALD trial, a multicenter, international, randomized, open-label, controlled phase 3 trial evaluated elacestrant as a monotherapy versus SoC for the treatment of ER+/HER2- advanced or mBC. The trial enrolled patients who had received 1 or 2 prior lines of endocrine therapy. Prior progression on an ET plus CDK4/6 inhibitors was mandated for all patients. Up to 1 line of chemotherapy was allowed. EMERALD met its two primary endpoints: progression-free survival in the overall population and PFS in patients with tumors harboring Estrogen Receptor 1 mutations. Menarini plans to pursue combination studies and initiate activity in new lines of therapy such as the adjuvant setting, enabling elacestrant to be utilized in fully addressing the highest unmet needs for ER+/HER2-patients. In 2018, elacestrant received fast track designation from the FDA. Trial Results: All patients were mandated to be treated with CDK 4/6 inhibitors. Moreover, patient population characteristics showed that 69.4% of patients had visceral metastasis and 22.2% received chemotherapy. EMERALD met both primary endpoints, which measured PFS of elacestrant as a monotherapy vs. SoC in the overall and mESR1 populations: Overall Population Reduced risk of progression or death vs. SoC by 30% Extended median PFS by 2.79 months versus SoC of 1.91 At 12 months, probability of PFS was 22.3% with elacestrant vs. 9.4% with SoC Compared to fulvestrant, elacestrant reduced risk of progression or death by 32% ESR1 Mutation Population Reduced risk of progression or death versus SoC by 45% Extended median PFS by 3.78 months versus SoC of 1.87 At 12 months, probability of PFS was 26.8% with elacestrant vs. 8.2% with SoC Compared to fulvestrant, elacestrant reduced the risk of progression or death by 50%. In both patient populations, results in key pre-specified subgroups, including visceral metastases, number of prior lines, and geographical region, were consistent with the overall outcome A key secondary endpoint for the EMERALD trial is Overall Survival. A pre specified interim analysis indicates a trend favoring elacestrant over SoC in both patient groups. Final analysis is expected to occur in late 2022 or early 2023. Safety Results: Elacestrant was well tolerated with an encouraging safety profile consistent with other ETs: TEAEs leading to discontinuation: infrequent in both elacestrant and SoC arms Grade 3 and higher TRAE were 7.2% for elacestrant and 3.1% for SoC Grade 3 and higher adverse events for elacestrant: nausea, vomiting and diarrhea were 2.5%, 0.8% and 0%, respectively A detailed evaluation of data is ongoing and additional results are expected to be published in a peer-reviewed journal.

OTHER BREAKING NEWS FROM THE FLY

Options
HP Inc. put volume heavy and directionally bearish » 13:55
01/27/22
01/27
13:55
01/27/22
13:55
HPQ

HP Inc.

$35.05 /

-0.18 (-0.51%)

Bearish flow noted in HP…

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HPQ HP Inc.
$35.05 /

-0.18 (-0.51%)

HPQ HP Inc.
$35.05 /

-0.18 (-0.51%)

01/20/22 JPMorgan
HP Inc. price target raised to $40 from $38 at JPMorgan
01/11/22 Bernstein
HP Inc. price target raised to $40 from $32 at Bernstein
12/17/21 Lynx
Micron price target raised to $105 from $67 at Lynx
11/24/21 Evercore ISI
HP Inc. price target raised to $40 from $35 at Evercore ISI
HPQ HP Inc.
$35.05 /

-0.18 (-0.51%)

HPQ HP Inc.
$35.05 /

-0.18 (-0.51%)

HPQ HP Inc.
$35.05 /

-0.18 (-0.51%)

HPQ HP Inc.
$35.05 /

-0.18 (-0.51%)

General news
Treasury Action: the market is sustaining its flattener » 13:55
01/27/22
01/27
13:55
01/27/22
13:55
$ECON

Economic Data

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Treasury Action: the…

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Options
Eargo options imply 14.5% move in share price post-earnings » 13:49
01/27/22
01/27
13:49
01/27/22
13:49
EAR

Eargo

$4.42 /

-0.145 (-3.18%)

Pre-earnings options…

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EAR Eargo
$4.42 /

-0.145 (-3.18%)

EAR Eargo
$4.42 /

-0.145 (-3.18%)

09/23/21
Fly Intel: Top five analyst downgrades
09/23/21 William Blair
William Blair downgrades Eargo on 'multiple unknowns' from criminal probe
09/23/21 Wells Fargo
Wells Fargo cuts Eargo to Equal Weight, slashes price target $10 from $52
09/23/21 William Blair
Eargo downgraded to Market Perform from Outperform at William Blair
EAR Eargo
$4.42 /

-0.145 (-3.18%)

EAR Eargo
$4.42 /

-0.145 (-3.18%)

EAR Eargo
$4.42 /

-0.145 (-3.18%)

Hot Stocks
Toll Brothers opens new active adult community in Hudson, Mass » 13:47
01/27/22
01/27
13:47
01/27/22
13:47
TOL

Toll Brothers

$54.85 /

-1.3 (-2.32%)

Toll Brothers announced…

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TOL Toll Brothers
$54.85 /

-1.3 (-2.32%)

TOL Toll Brothers
$54.85 /

-1.3 (-2.32%)

08:21 Today BofA
BofA double downgrades Toll Brothers to Underperform ahead of rise in rates
06:12 Today BofA
Toll Brothers downgraded to Underperform from Buy at BofA
01/19/22 UBS
Toll Brothers initiated with a Neutral at UBS
01/19/22 KeyBanc
Toll Brothers downgraded to Underweight from Sector Weight at KeyBanc
TOL Toll Brothers
$54.85 /

-1.3 (-2.32%)

TOL Toll Brothers
$54.85 /

-1.3 (-2.32%)

TOL Toll Brothers
$54.85 /

-1.3 (-2.32%)

TOL Toll Brothers
$54.85 /

-1.3 (-2.32%)

Options
Lumen Technologies call volume above normal and directionally bullish » 13:45
01/27/22
01/27
13:45
01/27/22
13:45
LUMN

Lumen

$11.80 /

-0.21 (-1.75%)

Bullish option flow…

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LUMN Lumen
$11.80 /

-0.21 (-1.75%)

LUMN Lumen
$11.80 /

-0.21 (-1.75%)

11/04/21 Citi
Citi upgrades Lumen to Neutral on revised capital allocation plan
11/04/21 Citi
Lumen upgraded to Neutral from Sell at Citi
08/05/21 Citi
Lumen dividend cut more likely post-2021, says Citi
07/26/21 Cowen
Lumen's LatAm sale may be sign of more to come, says Cowen
LUMN Lumen
$11.80 /

-0.21 (-1.75%)

  • 13
    Jan
LUMN Lumen
$11.80 /

-0.21 (-1.75%)

LUMN Lumen
$11.80 /

-0.21 (-1.75%)

Conference/Events
Biostage to host conference call » 13:45
01/27/22
01/27
13:45
01/27/22
13:45
BSTG

Biostage

$3.61 /

+ (+0.00%)

Conference call to…

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BSTG Biostage
$3.61 /

+ (+0.00%)

Hot Stocks
Kroger to add spoke facility in Louisville, Kentucky powered by the Ocado » 13:40
01/27/22
01/27
13:40
01/27/22
13:40
KR

Kroger

$44.76 /

+0.39 (+0.88%)

The Kroger announced it…

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KR Kroger
$44.76 /

+0.39 (+0.88%)

KR Kroger
$44.76 /

+0.39 (+0.88%)

01/25/22 Wells Fargo
Wells Fargo downgrades Kroger to Underweight with $42 price target
01/25/22 Wells Fargo
Kroger downgraded to Underweight from Equal Weight at Wells Fargo
01/19/22 BofA
Kroger upgraded to Neutral from Underperform at BofA
12/03/21 MKM Partners
Kroger price target raised to $48 from $44 at MKM Partners
KR Kroger
$44.76 /

+0.39 (+0.88%)

KR Kroger
$44.76 /

+0.39 (+0.88%)

KR Kroger
$44.76 /

+0.39 (+0.88%)

KR Kroger
$44.76 /

+0.39 (+0.88%)

General news
Treasury's $53 B 7-year auction was very well received » 13:35
01/27/22
01/27
13:35
01/27/22
13:35
$ECON

Economic Data

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+

Treasury's $53 B…

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Options
Atlassian options imply 9.7% move in share price post-earnings » 13:34
01/27/22
01/27
13:34
01/27/22
13:34
TEAM

Atlassian

$299.11 /

+5.47 (+1.86%)

Pre-earnings options…

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TEAM Atlassian
$299.11 /

+5.47 (+1.86%)

TEAM Atlassian
$299.11 /

+5.47 (+1.86%)

01/24/22 Citi
Atlassian assumed with a Buy at Citi
01/20/22 Cowen
Atlassian price target lowered to $325 from $380 at Cowen
01/20/22 Cowen
Atlassian price target lowered to $325 from $380 at Cowen
01/18/22 Truist
Atlassian price target lowered to $400 from $500 at Truist
TEAM Atlassian
$299.11 /

+5.47 (+1.86%)

TEAM Atlassian
$299.11 /

+5.47 (+1.86%)

TEAM Atlassian
$299.11 /

+5.47 (+1.86%)

Hot Stocks
SPRC Stock trading resumes  13:33
01/27/22
01/27
13:33
01/27/22
13:33
SPRC

SciSparc

$5.50 /

+ (+0.00%)

 
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SPRC SciSparc
$5.50 /

+ (+0.00%)

Hot Stocks
SPRC Stock trading halted, volatility trading pause  13:28
01/27/22
01/27
13:28
01/27/22
13:28
SPRC

SciSparc

$5.50 /

+ (+0.00%)

 
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SPRC SciSparc
$5.50 /

+ (+0.00%)

Hot Stocks
PyroGenesis says 'no undisclosed events to warrant' decline in stock price » 13:28
01/27/22
01/27
13:28
01/27/22
13:28
PYR

PyroGenesis

$1.87 /

-0.25 (-11.79%)

PyroGenesis Canada issued…

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PYR PyroGenesis
$1.87 /

-0.25 (-11.79%)

PYR PyroGenesis
$1.87 /

-0.25 (-11.79%)

PYR PyroGenesis
$1.87 /

-0.25 (-11.79%)

Technical Analysis
NASDAQ market internals summary » 13:23
01/27/22
01/27
13:23
01/27/22
13:23
$NSD

NASDAQ Market Internals

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Volume is above average…

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Technical Analysis
NYSE market internals summary » 13:22
01/27/22
01/27
13:22
01/27/22
13:22
$NYE

NYSE Market Internals

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+

Volume is above average…

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Downgrade
Associated British Foods downgraded to Sell from Neutral at Goldman Sachs » 13:22
01/27/22
01/27
13:22
01/27/22
13:22
ASBFY

Associated British Foods

$27.07 /

-0.25 (-0.92%)

Goldman Sachs analyst…

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ASBFY Associated British Foods
$27.07 /

-0.25 (-0.92%)

01/24/22 RBC Capital
Associated British Foods cut to Sector Perform from Outperform at RBC Capital
12/10/21 UBS
Associated British Foods price target lowered to 2,700 GBp at UBS
11/10/21 Deutsche Bank
Associated British Foods price target raised to 2,300 GBp at Deutsche Bank
11/10/21 JPMorgan
Associated British Foods price target lowered to 2,100 GBp at JPMorgan
On The Fly
Fly Intel: What to watch in Apple earnings report » 13:20
01/27/22
01/27
13:20
01/27/22
13:20
AAPL

Apple

$160.40 /

+0.52 (+0.33%)

, FB

Meta Platforms

$297.14 /

+2.82 (+0.96%)

, MVRS

Meta Platforms

/

+

, GOOGL

Alphabet Class A

$2,601.00 /

+13.18 (+0.51%)

, GOOG

Alphabet

$2,599.86 /

+9.38 (+0.36%)

Apple (AAPL) is scheduled…

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AAPL Apple
$160.40 /

+0.52 (+0.33%)

FB Meta Platforms
$297.14 /

+2.82 (+0.96%)

MVRS Meta Platforms
/

+

GOOGL Alphabet Class A
$2,601.00 /

+13.18 (+0.51%)

GOOG Alphabet
$2,599.86 /

+9.38 (+0.36%)

AAPL Apple
$160.40 /

+0.52 (+0.33%)

01/26/22 RBC Capital
Meta Platforms price target lowered to $400 from $415 at RBC Capital
01/25/22 BofA
BofA sees 'strong' December quarter for Apple ahead of 'seasonally weaker' one
01/25/22 Wedbush
Wedbush bullish on Apple, expects robust numbers despite chip shortage
01/24/22 Goldman Sachs
Goldman Sachs 'slightly cautious' on Apple heading into earnings
FB Meta Platforms
$297.14 /

+2.82 (+0.96%)

01/26/22 RBC Capital
Meta Platforms price target lowered to $400 from $415 at RBC Capital
01/19/22 OTR Global
Meta Platforms view upgraded to Positive from Mixed at OTR Global
01/19/22 Morgan Stanley
Meta Platforms price target raised to $395 from $365 at Morgan Stanley
01/18/22 JPMorgan
Meta Platforms remains top pick at JPMorgan despite reduced target
MVRS Meta Platforms
/

+

01/19/22 OTR Global
Meta Platforms view upgraded to Positive from Mixed at OTR Global
01/19/22 Morgan Stanley
Meta Platforms price target raised to $395 from $365 at Morgan Stanley
01/18/22 JPMorgan
Meta Platforms remains top pick at JPMorgan despite reduced target
01/11/22 JPMorgan
Amazon 'strong favorite' to be best performing FANG stock, JPMorgan says
GOOGL Alphabet Class A
$2,601.00 /

+13.18 (+0.51%)

01/24/22 BofA
Bofa adds two, removes three from best investment ideas list
01/19/22 BofA
Alphabet price target raised to $3,470 from $3,210 at BofA
01/19/22 Morgan Stanley
Alphabet price target raised to $3,430 from $3,200 at Morgan Stanley
01/19/22 Citi
Citi says other bidders could emerge for Activision Blizzard
GOOG Alphabet
$2,599.86 /

+9.38 (+0.36%)

01/19/22 BofA
Alphabet price target raised to $3,470 from $3,210 at BofA
01/19/22 Morgan Stanley
Alphabet price target raised to $3,430 from $3,200 at Morgan Stanley
01/19/22 Citi
Citi says other bidders could emerge for Activision Blizzard
01/13/22 Cowen
Alphabet price target raised to $3,500 from $3,360 at Cowen
AAPL Apple
$160.40 /

+0.52 (+0.33%)

FB Meta Platforms
$297.14 /

+2.82 (+0.96%)

GOOGL Alphabet Class A
$2,601.00 /

+13.18 (+0.51%)

GOOG Alphabet
$2,599.86 /

+9.38 (+0.36%)

AAPL Apple
$160.40 /

+0.52 (+0.33%)

FB Meta Platforms
$297.14 /

+2.82 (+0.96%)

MVRS Meta Platforms
/

+

GOOGL Alphabet Class A
$2,601.00 /

+13.18 (+0.51%)

GOOG Alphabet
$2,599.86 /

+9.38 (+0.36%)

AAPL Apple
$160.40 /

+0.52 (+0.33%)

FB Meta Platforms
$297.14 /

+2.82 (+0.96%)

MVRS Meta Platforms
/

+

GOOGL Alphabet Class A
$2,601.00 /

+13.18 (+0.51%)

GOOG Alphabet
$2,599.86 /

+9.38 (+0.36%)

AAPL Apple
$160.40 /

+0.52 (+0.33%)

FB Meta Platforms
$297.14 /

+2.82 (+0.96%)

GOOGL Alphabet Class A
$2,601.00 /

+13.18 (+0.51%)

AAPL Apple
$160.40 /

+0.52 (+0.33%)

Options
US Steel options imply 6.9% move in share price post-earnings » 13:19
01/27/22
01/27
13:19
01/27/22
13:19
X

U.S. Steel

$18.55 /

-0.065 (-0.35%)

Pre-earnings options…

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X U.S. Steel
$18.55 /

-0.065 (-0.35%)

X U.S. Steel
$18.55 /

-0.065 (-0.35%)

01/11/22 Wolfe Research
U.S. Steel downgraded to Underperform from Peer Perform at Wolfe Research
11/16/21 Wolfe Research
U.S. Steel initiated with a Peer Perform at Wolfe Research
11/09/21 Citi
U.S. Steel price target raised to $30 from $26 at Citi
10/29/21 Credit Suisse
U.S. Steel too cheap to ignore, says Credit Suisse
X U.S. Steel
$18.55 /

-0.065 (-0.35%)

  • 03
    Feb
X U.S. Steel
$18.55 /

-0.065 (-0.35%)

X U.S. Steel
$18.55 /

-0.065 (-0.35%)

X U.S. Steel
$18.55 /

-0.065 (-0.35%)

Hot Stocks
Ubisoft to shut down 'Hyper Scape' as of April 28 » 13:11
01/27/22
01/27
13:11
01/27/22
13:11
UBSFY

Ubisoft

$10.83 /

+0.12 (+1.12%)

Ubisoft said it has made…

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UBSFY Ubisoft
$10.83 /

+0.12 (+1.12%)

UBSFY Ubisoft
$10.83 /

+0.12 (+1.12%)

01/07/22 Morgan Stanley
Ubisoft price target lowered to EUR 62 from EUR 70 at Morgan Stanley
12/10/21 Barclays
Ubisoft price target lowered to EUR 43.50 from EUR 45.70 at Barclays
12/10/21 JPMorgan
Ubisoft price target lowered to EUR 55 from EUR 62 at JPMorgan
11/04/21 Berenberg
Ubisoft downgraded to Hold from Buy at Berenberg
UBSFY Ubisoft
$10.83 /

+0.12 (+1.12%)

UBSFY Ubisoft
$10.83 /

+0.12 (+1.12%)

UBSFY Ubisoft
$10.83 /

+0.12 (+1.12%)

Hot Stocks
Urban One trading resumes  13:08
01/27/22
01/27
13:08
01/27/22
13:08
UONE

Urban One

$5.30 /

-0.03 (-0.56%)

 
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UONE Urban One
$5.30 /

-0.03 (-0.56%)

UONE Urban One
$5.30 /

-0.03 (-0.56%)

General news
7-year note auction » 13:08
01/27/22
01/27
13:08
01/27/22
13:08
$ECON

Economic Data

/

+

Total Amount: $53B, Rate:…

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$ECON Economic Data
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Hot Stocks
Carnival sees dampening in booking activity for 2H22 » 13:05
01/27/22
01/27
13:05
01/27/22
13:05
CCL

Carnival

$19.73 /

-0.56 (-2.76%)

In a regulatory filing,…

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CCL Carnival
$19.73 /

-0.56 (-2.76%)

CCL Carnival
$19.73 /

-0.56 (-2.76%)

01/05/22 Jefferies
Carnival initiated with a Hold at Jefferies
12/21/21 Goldman Sachs
Carnival price target lowered to $21 from $24 at Goldman Sachs
10/25/21
Fly Intel: Top five analyst downgrades
10/25/21 Citi
Citi downgrades Carnival to Neutral, sees more upside in Norwegian
CCL Carnival
$19.73 /

-0.56 (-2.76%)

  • 23
    Feb
CCL Carnival
$19.73 /

-0.56 (-2.76%)

CCL Carnival
$19.73 /

-0.56 (-2.76%)

CCL Carnival
$19.73 /

-0.56 (-2.76%)

Options
Robinhood Markets options imply 16.2% move in share price post-earnings » 13:04
01/27/22
01/27
13:04
01/27/22
13:04
HOOD

Robinhood

$11.71 /

-0.67 (-5.41%)

Pre-earnings options…

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HOOD Robinhood
$11.71 /

-0.67 (-5.41%)

HOOD Robinhood
$11.71 /

-0.67 (-5.41%)

01/25/22 Mizuho
Robinhood price target lowered to $20 from $55 at Mizuho
01/14/22 KeyBanc
Robinhood price target lowered to $25 from $50 at KeyBanc
01/13/22 Deutsche Bank
Robinhood price target lowered to $15 from $17 at Deutsche Bank
01/10/22 Piper Sandler
Robinhood price target lowered to $17 from $38 at Piper Sandler
HOOD Robinhood
$11.71 /

-0.67 (-5.41%)

  • 29
    Jul
HOOD Robinhood
$11.71 /

-0.67 (-5.41%)

HOOD Robinhood
$11.71 /

-0.67 (-5.41%)

HOOD Robinhood
$11.71 /

-0.67 (-5.41%)

Hot Stocks
Urban One trading halted, volatility trading pause  13:03
01/27/22
01/27
13:03
01/27/22
13:03
UONE

Urban One

$5.30 /

-0.03 (-0.56%)

 
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UONE Urban One
$5.30 /

-0.03 (-0.56%)

Hot Stocks
CMS Energy board raises quarterly dividend to 46c per share » 13:01
01/27/22
01/27
13:01
01/27/22
13:01
CMS

CMS Energy

$62.71 /

+0.37 (+0.59%)

The Board of Directors of…

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CMS CMS Energy
$62.71 /

+0.37 (+0.59%)

CMS CMS Energy
$62.71 /

+0.37 (+0.59%)

12/23/21 UBS
CMS Energy price target raised to $69 from $65 at UBS
12/17/21
Fly Intel: Top five analyst downgrades
12/17/21 BofA
CMS Energy downgraded to Neutral from Buy at BofA
12/17/21 BofA
CMS Energy downgraded to Neutral from Buy at BofA
CMS CMS Energy
$62.71 /

+0.37 (+0.59%)

Hot Stocks
Southwest sees 2022 capacity down roughly 4% vs 2019 » 12:48
01/27/22
01/27
12:48
01/27/22
12:48
LUV

Southwest

$43.59 /

-0.09 (-0.21%)

Previous view flat vs…

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LUV Southwest
$43.59 /

-0.09 (-0.21%)

LUV Southwest
$43.59 /

-0.09 (-0.21%)

01/14/22 Barclays
Southwest price target lowered to $59 from $65 at Barclays
01/13/22 Susquehanna
Southwest downgraded to Neutral from Positive at Susquehanna
01/12/22 Wolfe Research
Southwest downgraded to Peer Perform from Outperform at Wolfe Research
01/12/22 Wolfe Research
Southwest downgraded to Peer Perform from Outperform at Wolfe Research
LUV Southwest
$43.59 /

-0.09 (-0.21%)

LUV Southwest
$43.59 /

-0.09 (-0.21%)

LUV Southwest
$43.59 /

-0.09 (-0.21%)

LUV Southwest
$43.59 /

-0.09 (-0.21%)

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