2022-01-13 07:32:36 BBIO BridgeBio
Amgen
01/13/22 01/1307:32 01/13/2207:32 | BridgeBio announces clinical collaboration with Amgen to study BBP-398BridgeBio Pharma announced a non-exclusive clinical collaboration with Amgen (AMGN) to evaluate the combination of BBP-398, a potentially best-in-class SHP2 inhibitor, with LUMAKRAS, a KRASG12C inhibitor, in patients with advanced solid tumors with the KRAS G12C mutation. The Phase 1/2 study will include a dose escalation period followed by dose expansion and optimization, and is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of BBP-398 in combination with LUMAKRAS. Under the terms of the non-exclusive collaboration, BridgeBio will sponsor the study and Amgen will provide a global supply of LUMAKRAS. BridgeBio
Amgen
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