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2022-05-05 09:09:00 LUMO Lumos Pharma $8.26 / -0.065 (-0.78%) 09:09 05/05/22 05/05 09:09 05/05/22 09:09	Lumos Pharma, MGH enter clinical collaboration for oral LUM-201 Lumos Pharma announced a collaboration with Laura Dichtel, MD of Massachusetts General Hospital to evaluate the orally administered growth hormone secretagogue, LUM-201, in Nonalcoholic Fatty Liver Disease. The investigational new drug application for this pilot trial has received a study may proceed letter by the FDA. This investigator-initiated Phase 2 trial is a single-site, 6-month, open-label pilot study of daily oral LUM-201 in adults with NAFLD. The trial will evaluate a dose of 25 mg/day of LUM-201 in 10 men and women with NAFLD. GH is a critical stimulator of lipolysis, and preclinical data suggest that amplifying GH secretion has the potential to reduce hepatic steatosis and prevent NAFLD progression. Interestingly, enhancing the natural pulsatile release of GH has been shown clinically in short-term studies to be more efficacious in inducing lipolysis than continuous infusions of GH. The primary endpoints will be to determine the changes in both intrahepatic lipid content and hepatic inflammation and fibrosis with growth hormone augmentation as measured by 1H-MRS and Perspectum's LiverMultiScan. Perspectum's LiverMultiScan is the leading non-invasive digital tool for liver diagnostics, giving physicians key indications of liver tissue characteristics to empower their diagnostic and patient management decisions. Biopsies will be conducted on a subset of patients to obtain additional information at the genetic and cellular level in this indication. Lumos Pharma approved an unsolicited grant application for this study and will supply LUM-201 for this pilot trial. Lumos Pharma has a pending application for a method-of-use patent for LUM-201 in NAFLD and retains all intellectual property rights for LUM-201 in this indication.	10 May

2022-05-05 09:09:00

LUMO

Lumos Pharma

$8.26 / -0.065 (-0.78%)

09:09

05/05/22

05/05

09:09

05/05/22

09:09

Lumos Pharma, MGH enter clinical collaboration for oral LUM-201

Lumos Pharma announced a collaboration with Laura Dichtel, MD of Massachusetts General Hospital to evaluate the orally administered growth hormone secretagogue, LUM-201, in Nonalcoholic Fatty Liver Disease. The investigational new drug application for this pilot trial has received a study may proceed letter by the FDA. This investigator-initiated Phase 2 trial is a single-site, 6-month, open-label pilot study of daily oral LUM-201 in adults with NAFLD. The trial will evaluate a dose of 25 mg/day of LUM-201 in 10 men and women with NAFLD. GH is a critical stimulator of lipolysis, and preclinical data suggest that amplifying GH secretion has the potential to reduce hepatic steatosis and prevent NAFLD progression. Interestingly, enhancing the natural pulsatile release of GH has been shown clinically in short-term studies to be more efficacious in inducing lipolysis than continuous infusions of GH. The primary endpoints will be to determine the changes in both intrahepatic lipid content and hepatic inflammation and fibrosis with growth hormone augmentation as measured by 1H-MRS and Perspectum's LiverMultiScan. Perspectum's LiverMultiScan is the leading non-invasive digital tool for liver diagnostics, giving physicians key indications of liver tissue characteristics to empower their diagnostic and patient management decisions. Biopsies will be conducted on a subset of patients to obtain additional information at the genetic and cellular level in this indication. Lumos Pharma approved an unsolicited grant application for this study and will supply LUM-201 for this pilot trial. Lumos Pharma has a pending application for a method-of-use patent for LUM-201 in NAFLD and retains all intellectual property rights for LUM-201 in this indication.

10
May

OTHER BREAKING NEWS FROM THE FLY

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General news	The U.S. consumer confidence rise to 104.2 » 10:25 03/28/23 03/28 10:25 03/28/23 10:25 $ECON Economic Data / + The U.S. consumer… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Periodicals On The Fly Technical Analysis $ECON Economic Data / + 03/22/23 Senators Scott, Warren unveil bipartisan Fed oversight legislation 03/01/23 Einhorn says investors should be 'bearish on stocks and bullish on inflation' $ECON Economic Data / + $ECON Economic Data / + 03/08/23 Biden to propose 25% billionaire tax, Bloomberg says 03/08/23 Biden to propose 25% billionaire tax, Bloomberg says 03/07/23 Powell tells Congress data from January partly reversed softening trends 01/30/23 Fed likely to raise funds rate benchmark by quarter percentage point, WSJ says $ECON Economic Data / + 03/22/23 What You Missed On Wall Street On Wednesday 03/21/23 What You Missed On Wall Street On Tuesday 03/21/23 What You Missed On Wall Street This Morning 03/08/23 What You Missed On Wall Street On Wednesday $ECON Economic Data / + 03/22/23 Fed says 'additional policy firming may be appropriate'
Conference/Events	JPMorgan software analyst to hold an analyst/industry conference call » 10:25 03/28/23 03/28 10:25 03/28/23 10:25 Mid & Small Cap… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial
Conference/Events	Euronet to participate in a conference call with Northland » 10:25 03/28/23 03/28 10:25 03/28/23 10:25 EEFT Euronet $109.09 / -0.48 (-0.44%) Investor presentation… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Events EEFT Euronet $109.09 / -0.48 (-0.44%) 03/23/23 Euronet's Ria Money Transfer to sponsor FC Internazionale Milano 03/09/23 Euronet's Ria Money Transfer partners with ACLEDA 02/01/23 Euronet's platform to enhance prepaid card issuing services for SOLFIN 12/15/22 Euronet launches refreshed brand strategy, new logo, mission statement EEFT Euronet $109.09 / -0.48 (-0.44%) 01/23/23 Citi Euronet downgraded to Neutral from Buy at Citi 01/20/23 Truist Euronet price target raised to $135 from $100 at Truist 01/12/23 DA Davidson DA Davidson expects material FX headwinds for Euronet to diminish 01/05/23 Wolfe Research Euronet downgraded to Underperform from Peer Perform at Wolfe Research EEFT Euronet $109.09 / -0.48 (-0.44%) 02/08/23 Euronet reports Q4 adjusted EPS $1.39, consensus $1.24 11:00 Today Euronet - EEFT 05/03/23 Euronet - EEFT
Conference/Events	Porch Group participates in a conference call with Cantor Fitzgerald » 10:25 03/28/23 03/28 10:25 03/28/23 10:25 PRCH Porch Group $1.39 / +0.09 (+6.92%) Technology Analysts… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings On The Fly Events PRCH Porch Group $1.39 / +0.09 (+6.92%) 03/20/23 Porch Group files application to form a reciprocal insurance exchange 02/27/23 Porch Group's V12 rebrands Porch Group Media 11/23/22 Porch Group CEO reports purchase of 256,949 shares of common stock 11/02/22 Porch Group appoints Shawn Tabak as CFO PRCH Porch Group $1.39 / +0.09 (+6.92%) 03/15/23 Loop Capital Loop cuts Porch Group to Hold after Q4 miss, sees 2023 as transition year 03/15/23 Loop Capital Porch Group downgraded to Hold from Buy at Loop Capital 12/28/22 Stephens Stephens carries over seven stocks to 'Best Ideas' list for 2023 11/09/22 Oppenheimer Porch Group price target lowered to $3 from $9 at Oppenheimer PRCH Porch Group $1.39 / +0.09 (+6.92%) 03/14/23 Porch Group sees FY23 revenue $330M-$350M, consensus $331.74M 03/14/23 Porch Group reports Q4 EPS (36c), consensus (28c) 11/08/22 Porch Group lowers FY22 revenue view to $275M from $290M, consensus $289.84M 11/08/22 Porch Group reports Q3 EPS (88c), consensus (20c) PRCH Porch Group $1.39 / +0.09 (+6.92%) 03/15/23 What You Missed On Wall Street On Wednesday 03/15/23 What You Missed On Wall Street This Morning 03/15/23 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 10:30 Today Porch Group - PRCH

Conference/Events	Praxis Precision Medicines participates in a conference call with HC Wainwright » 10:25 03/28/23 03/28 10:25 03/28/23 10:25 PRAX Praxis Precision Medicines / + Conference call with CEO… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Events PRAX Praxis Precision Medicines / + 03/03/23 Praxis Precision plunges as primary endpoint didn't hit statistical significance 03/03/23 Praxis Precision Medicines announces results from Essential1 study 12/13/22 Praxis in strategic epilepsy pact with UCB for up to $100M potential 11/28/22 Praxis to advance PRAX-562 Phase 2 study in pediatric patients PRAX Praxis Precision Medicines / + 03/06/23 William Blair Praxis downgraded to Market Perform after trial miss at William Blair 03/06/23 H.C. Wainwright Praxis Precision should move to Phase 3 despite miss, says H.C. Wainwright 03/03/23 William Blair Praxis Precision downgraded to Market Perform from Outperform at William Blair 02/07/23 Piper Sandler Piper has 'strong conviction' in odds of Praxis Precision's PRAX-944 succeeding PRAX Praxis Precision Medicines / + 02/07/23 Praxis Precision Medicines reports Q4 EPS (87c), consensus (78c) 11/09/22 Praxis Precision Med reports Q3 EPS (96c), consensus (89c) 11:00 Today Praxis Precision Medicines - PRAX
Conference/Events	US Treasury Department to hold a meeting » 10:25 03/28/23 03/28 10:25 03/28/23 10:25 The Treasury Department… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial
On The Fly	Harmony plunges as Scorpion seeks FDA withdrawal of Wakix approval » 10:20 03/28/23 03/28 10:20 03/28/23 10:20 HRMY Harmony Biosciences $32.38 / -9.12 (-21.98%) Shares of Harmony… Open Full Text ShowHide Related Items >><< Company News Street Research Earnings Periodicals On The Fly HRMY Harmony Biosciences $32.38 / -9.12 (-21.98%) 01/09/23 Novavax names John Jacobs as new CEO, succeeding Stanley Erck 01/06/23 Harmony Biosciences CEO John Jacobs stepping down 11/15/22 Harmony Biosciences director sells $9.12M in common stock 11/01/22 Harmony Biosciences reports topline Phase 2 results of pitolisant HRMY Harmony Biosciences $32.38 / -9.12 (-21.98%) 02/22/23 Mizuho Harmony Biosciences price target lowered to $60 from $70 at Mizuho 01/04/23 Piper Sandler Harmony Biosciences price target raised to $70 from $62 at Piper Sandler 11/08/22 Mizuho Harmony Biosciences price target raised to $70 from $60 at Mizuho 10/14/22 Jefferies Jefferies upgrades 'undervalued' Harmony Biosciences to Buy HRMY Harmony Biosciences $32.38 / -9.12 (-21.98%) 02/21/23 Harmony Biosciences reports Q4 non-GAAP EPS $1.01, consensus 58c 11/01/22 Harmony Biosciences reports Q3 non-GAAP EPS 95c vs 41c last year HRMY Harmony Biosciences $32.38 / -9.12 (-21.98%) 09:47 Today Scorpion: Filing Citizen's Petition to request withdrawal of Harmony drug 09:47 Today Scorpion Capital issues investigative report on Harmony Biosciences HRMY Harmony Biosciences $32.38 / -9.12 (-21.98%) 10/14/22 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations
Recommendations	Alibaba can unlock 'significant value' with restructuring, says Morgan Stanley » 10:19 03/28/23 03/28 10:19 03/28/23 10:19 BABA Alibaba $94.05 / +7.92 (+9.20%) After Alibaba said it… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Periodicals On The Fly Options BABA Alibaba $94.05 / +7.92 (+9.20%) 09:47 Today Alibaba rises 12.4% 07:13 Today Alibaba to reorganize into six business groups and other investments 02/23/23 Alibaba jumps 6% to $100.65 after Q3 results beat estimates 02/23/23 Alibaba CEO sees 'continued recovery in consumer sentiment' BABA Alibaba $94.05 / +7.92 (+9.20%) 02/28/23 Susquehanna Alibaba price target lowered to $175 from $185 at Susquehanna 02/24/23 UBS Vipshop upgraded to Buy at UBS on apparel demand recovery 02/24/23 Truist Alibaba price target raised to $130 from $120 at Truist 02/24/23 KGI Securities Alibaba upgraded to Outperform from Neutral at KGI Securities BABA Alibaba $94.05 / +7.92 (+9.20%) 02/23/23 Alibaba reports Q3 adjusted EPS $2.79, consensus $2.37 02/22/23 Notable companies reporting before tomorrow's open 02/22/23 Notable companies reporting before tomorrow's open 11/17/22 Alibaba reports Q2 adjusted EPS $1.82, consensus $1.64 BABA Alibaba $94.05 / +7.92 (+9.20%) 06:04 Today Alibaba plans to split into six main units, explore IPOs, Bloomberg reports 03/27/23 Alibaba founder Jack Ma returns to China, Reuters reports 03/22/23 Part of Alibaba shareholder lawsuit dismissed by judge, Reuters reports 02/27/23 Tencent sets up team to work on ChatGPT-style chatbot, Reuters reports BABA Alibaba $94.05 / +7.92 (+9.20%) 08:51 Today Fly Intel: Pre-market Movers 03/27/23 What You Missed On Wall Street This Morning 03/27/23 Fly Intel: Pre-market Movers 03/22/23 What You Missed On Wall Street On Wednesday BABA Alibaba $94.05 / +7.92 (+9.20%) 09:40 Today Unusually active option classes on open March 28th 03/24/23 Alibaba call volume above normal and directionally bullish 03/24/23 Unusually active option classes on open March 24th 03/23/23 Unusually active option classes on open March 23rd
Hot Stocks	Guardion Health Sciences Inc trading halted, volatility trading pause 10:18 03/28/23 03/28 10:18 03/28/23 10:18 GHSI Guardion Health Sciences $7.88 / +1.715 (+27.82%) ShowHide Related Items >><< Company News Street Research Earnings GHSI Guardion Health Sciences $7.88 / +1.715 (+27.82%) 03/06/23 Guardion Health Sciences retains Atlantra to explore strategic alternatives 01/24/23 Guardion Health Sciences regains compliance with Nasdaq 01/06/23 Guardion Health Sciences announces 1-for-50 reverse stock split 10/06/22 Guardion Health announces clinical results on Viactiv Omega Boost Gel Bites GHSI Guardion Health Sciences $7.88 / +1.715 (+27.82%) 07/18/22 Ascendiant Guardion Health Sciences initiated with a Buy at Ascendiant GHSI Guardion Health Sciences $7.88 / +1.715 (+27.82%) 11/14/22 Guardion Health Sciences reports Q3 EPS (3c) vs (12c) last year

Events

Earnings calls, analyst events, roadshows and more

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Jim Cramer Monthly Meeting: March 2023 Government Event

Webcast
Today at 13:00

5-Year Note Auction Government Event
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Money Supply: M2 - M/M: February 2023 Government Event
Today at 13:00

FY2024 Request for the Commodity Futures Trading Commission Government Event

2362-A Rayburn House Office Building, Washington, D.C.
Today at 13:00

Healthcare Policy Industry Meetings
MU
Today at 16:30

Micron - MU Conference Calls
TSHA
Today at 16:30

Taysha Gene Therapies - TSHA Conference Calls
ARCT
Today at 16:30

Arcturus Therapeutics - ARCT Conference Calls
KITT
Today at 16:30

Nauticus Robotics - KITT Conference Calls
SLGC
Today at 16:30

SomaLogic - SLGC Conference Calls

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Syndicate

This week’s upcoming IPOs and secondary offerings

Priced
Not Priced

Mon	YGF X YGF YanGuFang IPO Managers: EF Hutton Priced at: $4.00 2M Shares ZJYL X ZJYL Jin Medical IPO Managers: Prime Number Priced at: $8.00 1M Shares
Tues	No deals
Wed	No deals
Thurs	No deals
Fri	No deals

Mon	No deals
Tues	No deals
Wed	No deals
Thurs	SYT X SYT Syla Technologies IPO Managers: Boustead $8.00 1.875M Shares
Fri	No deals

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Lumos Pharma, MGH enter clinical collaboration for oral LUM-201

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