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Hot Stocks
NeuBase Therapeutics appoints William Mann as COO » 08:10
07/28/20
07/28
08:10
07/28/20
08:10
NBSE

NeuBase Therapeutics

$7.41 /

-0.08 (-1.07%)

NeuBase Therapeutics…

NeuBase Therapeutics announced the appointment of industry veteran William Mann, Ph.D., MBA as COO. Most recently, he served as the president and CEO of Helsinn Therapeutics.

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NBSE NeuBase Therapeutics
$7.41 /

-0.08 (-1.07%)

NBSE NeuBase Therapeutics
$7.41 /

-0.08 (-1.07%)

06/16/20 RBC Capital
NeuBase Therapeutics initiated with an Outperform at RBC Capital
03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
NBSE NeuBase Therapeutics
$7.41 /

-0.08 (-1.07%)

  • 28
    Apr
NBSE NeuBase Therapeutics
$7.41 /

-0.08 (-1.07%)

Over a month ago
Hot Stocks
NeuBase Therapeutics added to Russell 3000, Microcap Indexes » 09:06
06/29/20
06/29
09:06
06/29/20
09:06
NBSE

NeuBase Therapeutics

$9.59 /

-0.74 (-7.16%)

NeuBase Therapeutics…

NeuBase Therapeutics announced that it has been added to the Russell 3000 and Russell Microcap Indexes at the conclusion of the 2020 Russell indexes annual reconstitution.

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NBSE NeuBase Therapeutics
$9.59 /

-0.74 (-7.16%)

NBSE NeuBase Therapeutics
$9.59 /

-0.74 (-7.16%)

06/16/20 RBC Capital
NeuBase Therapeutics initiated with an Outperform at RBC Capital
03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
NBSE NeuBase Therapeutics
$9.59 /

-0.74 (-7.16%)

  • 28
    Apr
NBSE NeuBase Therapeutics
$9.59 /

-0.74 (-7.16%)

Initiation
NeuBase Therapeutics initiated with an Outperform at RBC Capital » 06:00
06/16/20
06/16
06:00
06/16/20
06:00
NBSE

NeuBase Therapeutics

$10.36 /

+1.94 (+23.04%)

RBC Capital analyst Brian…

RBC Capital analyst Brian Abrahams initiated coverage of NeuBase Therapeutics with an Outperform rating and $16 price target. The analyst believes the company's preclinical protein nucleic acids show "considerable promise" and could have broad applicability in a number of diseases, including lead indications Huntington's disease and myotonic dystrophy.

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NBSE NeuBase Therapeutics
$10.36 /

+1.94 (+23.04%)

NBSE NeuBase Therapeutics
$10.36 /

+1.94 (+23.04%)

03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
11/20/19 Oppenheimer
NeuBase Therapeutics initiated with an Outperform at Oppenheimer
NBSE NeuBase Therapeutics
$10.36 /

+1.94 (+23.04%)

NBSE NeuBase Therapeutics
$10.36 /

+1.94 (+23.04%)

Earnings
NeuBase Therapeutics reports Q2 EPS (26c), consensus (22c) » 16:21
05/14/20
05/14
16:21
05/14/20
16:21
NBSE

NeuBase Therapeutics

$8.13 /

-0.51 (-5.90%)

At March 31, the company…

At March 31, the company had cash and cash equivalents of approximately $5.8M, compared with cash and cash equivalents of approximately $10.3M at September 30, 2019. Subsequent to the end of Q2, the Company completed a public equity offering that generated net proceeds of approximately $33.3M. The company believes that its current cash balance will provide sufficient capital to fund operations into Q2 of 2022. "We have generated a solid foundation of data that we expect will enable us to produce mutation-specific genetic medicines for a multitude of diseases. The positive non-human primate pharmacokinetic (biodistribution) and patient-derived cell line pharmacodynamic (activity) data released on March 31st illustrate our ability to create a new class of mutation silencing therapies. In addition, our proprietary targeting technology enables our PATrOL compounds to achieve therapeutically relevant drug concentrations throughout the body, including in the brain," said Dietrich Stephan, CEO of NeuBase. Our therapeutic development programs continue to drive forward, despite the difficult macroenvironment, as evidenced by the recent positive platform validation data and well-received public offering. As we look ahead, our initial focus is to continue advancing our Huntington's disease ("HD") and myotonic dystrophy type 1 ("DM1") programs through lead optimization and IND-enabling studies. We expect to announce the lead candidate for the NT0100 Program for HD by the end of calendar year 2020, followed by the initiation of IND-enabling studies during the first half of calendar year 2021. Finally, our unique biodistribution profile allows us the opportunity to develop therapies against targets and organ systems that we believe other antisense companies cannot currently reach in the body, including into the brain after systemic delivery, which is one of the grand challenges in drug delivery of macromolecules. We believe this unique ability validates our large opportunity in the antisense space."

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NBSE NeuBase Therapeutics
$8.13 /

-0.51 (-5.90%)

NBSE NeuBase Therapeutics
$8.13 /

-0.51 (-5.90%)

03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
11/20/19 Oppenheimer
NeuBase Therapeutics initiated with an Outperform at Oppenheimer
NBSE NeuBase Therapeutics
$8.13 /

-0.51 (-5.90%)

NBSE NeuBase Therapeutics
$8.13 /

-0.51 (-5.90%)

Over a quarter ago
Syndicate
NeuBase Therapeutics 5M share Spot Secondary priced at $6.00 » 09:33
04/28/20
04/28
09:33
04/28/20
09:33
NBSE

NeuBase Therapeutics

$8.16 /

+0.43 (+5.56%)

The deal size was…

The deal size was increased to $30M in common stock, up from $20M, and priced at the low-end of the $6.00-$6.25 range. Oppenheimer and BTIG acted as joint book running managers for the offering.

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NBSE NeuBase Therapeutics
$8.16 /

+0.43 (+5.56%)

03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
11/20/19 Oppenheimer
NeuBase Therapeutics initiated with an Outperform at Oppenheimer
  • 28
    Apr
Syndicate
NeuBase announces common stock offering, no amount given » 16:03
04/27/20
04/27
16:03
04/27/20
16:03
NBSE

NeuBase Therapeutics

$8.19 /

+0.46 (+5.95%)

NeuBase Therapeutics…

NeuBase Therapeutics announced that it has commenced an underwritten public offering of shares of common stock. NeuBase intends to use the net proceeds from this offering for working capital and general corporate purposes and to advance the development of its product candidates and expand its pipeline. Oppenheimer and BTIG are acting as the joint book-running managers for the offering, and National Securities Corporation is acting as co-manager.

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NBSE NeuBase Therapeutics
$8.19 /

+0.46 (+5.95%)

03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
11/20/19 Oppenheimer
NeuBase Therapeutics initiated with an Outperform at Oppenheimer
Conference/Events
NeuBase Therapeutics to host conference call » 07:48
03/31/20
03/31
07:48
03/31/20
07:48
NBSE

NeuBase Therapeutics

$6.15 /

-0.37 (-5.67%)

Management discusses the…

Management discusses the positive pre-clinical data validating its novel, genetic therapy PATrOL Platform on a conference call to be held on March 31 at 8 am. Webcast Link

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NBSE NeuBase Therapeutics
$6.15 /

-0.37 (-5.67%)

03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
11/20/19 Oppenheimer
NeuBase Therapeutics initiated with an Outperform at Oppenheimer
Hot Stocks
NeuBase announces preclinical data on genetic therapy PATrOL platform » 07:08
03/31/20
03/31
07:08
03/31/20
07:08
NBSE

NeuBase Therapeutics

$6.15 /

-0.37 (-5.67%)

NeuBase Therapeutics…

NeuBase Therapeutics announced positive preclinical data from its pharmacokinetics studies in non-human primates and in vitro pharmacodynamics data in patient-derived cell lines. NeuBase believes these data validate the key advantages of the proprietary NeuBase peptide-nucleic acid antisense oligonucleotide platform and support the Company's decision to advance the development of its Huntington's disease and myotonic dystrophy type 1 programs, as well as the potential expansion of its therapeutic pipeline into other indications. Non-Human Primate Pharmacokinetic Study: Quantitative whole-body autoradiography was performed on NHPs. A PATrOL-enabled compound was radio-labeled, and the resulting material was injected into NHPs at 5 mg/kg via a bolus tail vein injection. At four hours, twelve hours, and seven days post-dosing, NHPs were sacrificed and sectioned into 40 microm slices. Slices were exposed to autoradiography imaging plates alongside a dilution series of radioactive PNA in whole blood. Upon imaging, the dilution series enabled an analysis of the amount of compound in each of the tissues. In addition, prior to sacrifice, whole blood, urine, and feces were collected from the NHPs at specified timepoints. The major conclusions from this study include: Rapid uptake of compound out of the body's circulation after systemic intravenous administration, with a half-life in circulation of approximately 1.5 hours; Compound penetrates every organ system studied, including the central nervous system and skeletal muscle; Compound crosses the blood-brain barrier and into the key deep brain structures, including the caudate, supporting a key capability for the development of the Company's lead program in HD; Delivery of the compound to skeletal muscle, the primary organ system that is affected in DM1; Because both HD and DM1 have manifestations outside of the primary affected organ, the broad biodistribution of the compounds may enable a potential whole-body therapeutic solution in both indications. Therapeutically relevant doses persist for greater than one week in NHPs after single-dose injection; 96% of administered compound remained in vivo after a one-week period; Redistribution over one week after administration between organ systems enriches concentrations in key brain regions up to two-fold, including in those deep brain structures most relevant for HD; Retention of ~90% of compound concentrations achieved in skeletal muscle over the course of one-week post-single-dose administration; and Sustained concentrations in many other key organ systems throughout the body may indicate the potential for durable therapeutic responses and an infrequent dosing cadence. Patient-Derived Huntington's Cell Line Pharmacodynamic Studies: Multiple Huntington's disease candidate compounds were incubated with HD-derived cells and assayed for their toxicity and their ability to selectively knock down mutant huntingtin protein expression by engaging with the CAG repeat expansion in the huntingtin gene transcript. Multi-well plates were seeded with cells and candidates were added to the culture at various concentrations. Cells were grown for three days and thereafter assayed for cell death. Cell pellets were also collected, lysed, and run on gradient SDS-PAGE gels. Following the transfer of the proteins to a membrane, the membrane was probed with anti-huntingtin and anti-beta-actin antibodies. Secondary antibodies were used to image the immunoblots. The beta-actin bands were used to normalize the amount of protein across the wells. The amounts of mutant and wild type huntingtin protein in treated cells were compared to untreated cells to determine the level of knockdown. The major conclusions from this study include: Activity in engaging target disease-causing transcripts and knocking-down resultant malfunctioning mHTT protein levels preferentially over normal HTT protein knock-down; and Dose limiting toxicities were not observed relative to a control either at or above the doses demonstrating activity in human cells in vitro. In addition, PATrOL enabled compounds were generally well-tolerated in vivo after systemic administration, both after single dose administration in NHPs and multi dose administration in mice for over a month. The intersection of the NHP pharmacokinetic data and the in vitro patient-derived pharmacodynamic data provides a roadmap to create a pipeline of therapeutic candidates which can reach target tissues of interest after systemic administration and achieve the desired activity at that dose. NeuBase believes the data from these studies support the advancement of the Company's HD and DM1 programs into lead optimization and subsequent IND-enabling studies, as well as provide a roadmap for the future expansion of the Company's therapeutic pipeline into other indications, including oncology.

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NBSE NeuBase Therapeutics
$6.15 /

-0.37 (-5.67%)

03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
11/20/19 Oppenheimer
NeuBase Therapeutics initiated with an Outperform at Oppenheimer
On The Fly
Fly Intel: After-Hours Movers » 19:00
03/26/20
03/26
19:00
03/26/20
19:00
BGCP

BGC Partners

$3.26 /

+0.03 (+0.93%)

, TXMD

TherapeuticsMD

$1.26 /

-0.025 (-1.95%)

, VMW

VMware

$124.70 /

+8.54 (+7.35%)

, GPS

Gap

$8.43 /

-0.55 (-6.12%)

, LULU

Lululemon

$200.80 /

+7.18 (+3.71%)

, PRGS

Progress Software

$34.69 /

+1.67 (+5.06%)

, HTZ

Hertz

$7.24 /

-0.465 (-6.04%)

, KBH

KB Home

$18.95 /

-0.48 (-2.47%)

, GME

GameStop

$4.40 /

+0.19 (+4.51%)

, SPWH

Sportsman's Warehouse

$5.63 /

+0.03 (+0.54%)

, NBSE

NeuBase Therapeutics

$5.85 /

+0.15 (+2.63%)

, OSS

One Stop Systems

$1.53 /

+0.22 (+16.79%)

Check out this…

Open Full Text

ShowHide Related Items >><<
BGCP BGC Partners
$3.26 /

+0.03 (+0.93%)

TXMD TherapeuticsMD
$1.26 /

-0.025 (-1.95%)

02/21/20 H.C. Wainwright
TherapeuticsMD price target lowered to $6 from $7 at H.C. Wainwright
12/12/19 Stifel
Stifel says TherapeuticsMD's Annovera 'insulated' against generic NuvaRing
12/02/19 Guggenheim
TherapeuticsMD initiated with a Buy at Guggenheim
10/25/19 Stifel
TherapeuticsMD price target cut to $17 from $20 at Stifel
VMW VMware
$124.70 /

+8.54 (+7.35%)

03/24/20 Oppenheimer
VMware price target lowered to $165 from $200 at Oppenheimer
03/02/20 Jefferies
VMware price target lowered to $175 from $190 at Jefferies
02/28/20 RBC Capital
VMware price target lowered to $183 from $200 at RBC Capital
02/28/20 Deutsche Bank
VMware price target lowered to $165 from $190 at Deutsche Bank
GPS Gap
$8.43 /

-0.55 (-6.12%)

03/19/20 Morgan Stanley
Morgan Stanley lowers targets for Gap, Macy's, and four other levered retailers
03/13/20 BMO Capital
Gap price target lowered to $15 from $18 at BMO Capital
03/13/20 MKM Partners
Gap price target lowered to $11 from $19 at MKM Partners
03/12/20 Wedbush
Gap price target lowered to $12 from $20 at Wedbush
LULU Lululemon
$200.80 /

+7.18 (+3.71%)

03/23/20 RBC Capital
Lululemon price target lowered to $195 from $265 at RBC Capital
03/23/20 Needham
Lululemon upgraded to Buy from Hold at Needham
03/23/20 Needham
Lululemon upgraded to Buy from Hold at Needham
03/20/20 Citi
Lululemon upgraded to Buy from Neutral at Citi
PRGS Progress Software
$34.69 /

+1.67 (+5.06%)

01/17/20 Benchmark
Progress Software price target raised to $57 from $49 at Benchmark
10/22/19 Sidoti
Progress Software initiated with a Buy at Sidoti
09/27/19 Benchmark
Progress Software weakness overdone in after-hours trading, says Benchmark
07/26/19 Wedbush
Progress Software upgraded to Outperform from Neutral at Wedbush
HTZ Hertz
$7.24 /

-0.465 (-6.04%)

03/25/20
Fly Intel: Top five analyst downgrades
03/25/20 Barclays
Hertz downgraded to Equal Weight from Overweight at Barclays
03/24/20 Morgan Stanley
Morgan Stanley upgrades Auto industry rating to In-Line from Cautious
03/05/20 Morgan Stanley
Hertz, Avis risk from COVID-19 may be underappreciated, says Morgan Stanley
KBH KB Home
$18.95 /

-0.48 (-2.47%)

03/25/20 KeyBanc
KeyBanc upgrades KB Home to Overweight on valuation, policy response
03/24/20 KeyBanc
KB Home upgraded to Overweight from Sector Weight at KeyBanc
03/12/20 BofA
Foundation Building, Toll Brothers cut to Underperform, KB Home upgraded at BofA
03/12/20 BofA
KB Home upgraded to Buy from Neutral at BofA
GME GameStop
$4.40 /

+0.19 (+4.51%)

03/20/20
Fly Intel: Top five analyst downgrades
03/20/20 Benchmark
GameStop does not qualify as an essential retailer, says Benchmark
03/20/20 Wedbush
GameStop downgraded to Neutral from Outperform at Wedbush
03/20/20 Wedbush
GameStop downgraded to Neutral from Outperform at Wedbush
SPWH Sportsman's Warehouse
$5.63 /

+0.03 (+0.54%)

01/14/20 Piper Sandler
Sportsman's Warehouse recent selloff a buying opportunity, says Piper Sandler
01/10/20 Craig-Hallum
Buy Sportsman's Warehouse on the pullback, says Craig-Hallum
01/06/20 Lake Street
Sportsman's Warehouse initiated with a Buy at Lake Street
12/12/19 Craig-Hallum
Sportsman's Warehouse initiated with a Buy at Craig-Hallum
NBSE NeuBase Therapeutics
$5.85 /

+0.15 (+2.63%)

03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
11/20/19 Oppenheimer
NeuBase Therapeutics initiated with an Outperform at Oppenheimer
OSS One Stop Systems
$1.53 /

+0.22 (+16.79%)

08/06/19
Fly Intel: Top five analyst initiations
08/06/19 Benchmark
One Stop Systems transitioned with a Speculative Buy at Benchmark
04/04/19 Noble Capital
One Stop Systems initiated with an Outperform at Noble Capital
Earnings
NeuBase Therapeutics reports Q1 EPS (26c), consensus (32c) » 16:09
03/26/20
03/26
16:09
03/26/20
16:09
NBSE

NeuBase Therapeutics

$5.70 /

+ (+0.00%)

At December 31, 2019, the…

At December 31, 2019, the company had cash and cash equivalents of approximately $7.7M, compared with cash and cash equivalents of approximately $10.3M at September 30, 2019. The company believes that its current cash balance will provide sufficient capital to fund operations through the end of fiscal FY20.

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NBSE NeuBase Therapeutics
$5.70 /

+ (+0.00%)

03/06/20 Chardan
NeuBase Therapeutics initiated with a Buy at Chardan
02/07/20 Guggenheim
Guggenheim starts NeuBase Therapeutics at Buy with $13 price target
02/06/20 Guggenheim
NeuBase Therapeutics initiated with a Buy at Guggenheim
11/20/19 Oppenheimer
NeuBase Therapeutics initiated with an Outperform at Oppenheimer

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