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RARX

RA Pharmaceuticals

$8.95

-0.17 (-1.86%)

07:15
01/08/18
01/08
07:15
01/08/18
07:15

RA Pharmaceuticals initiates dosing in Phase 1b clinical study of RA101495 SC

Ra Pharmaceuticals announced that it has initiated dosing in the company's Phase 1b clinical trial evaluating RA101495 SC in patients with renal impairment. This trial is designed to characterize the pharmacokinetics of RA101495 SC in these patients, thereby enabling the evaluation of RA101495 SC in complement-mediated renal diseases, such as atypical hemolytic uremic disorder and lupus nephritis. Ra Pharma is a clinical stage biopharmaceutical company focusing on the development of next-generation therapeutics for the treatment of complement-mediated diseases and is developing RA101495 as a novel, subcutaneously-administered inhibitor of complement component 5. RA101495 SC is currently in Phase 2 clinical development for the treatment of paroxysmal nocturnal hemoglobinuria and generalized myasthenia gravis. The Phase 1b, multi-center, open-label trial is designed to evaluate the PK profile of RA101495 SC in patients with renal impairment. The trial is planned to enroll approximately 16 subjects, including eight patients with severe renal impairment matched with eight healthy control subjects with normal renal function. Each patient will receive a single, SC dose of 0.3 mg/kg of RA101495. The trial will compare the PK profile in patients with renal impairment with subjects with normal renal function.

  • 08

    Jan

RARX RA Pharmaceuticals
$8.95

-0.17 (-1.86%)

12/04/17
12/04/17
NO CHANGE
Target $170

Overweight
RA data 'underwhelms' compared to Alexion's Soliris, says Piper Jaffray
Today's paroxysmal nocturnal hemoglobinuria data from RA Pharmaceuticals (RARX) "underwhelms on efficacy" in comparison to Alexion's (ALNX) Soliris "and for that matter" ALXN1210, Piper Jaffray analyst Christopher Raymond tells investors in a research note titled "Remind Us Again... Why Are We Worried About Ra Pharmaceuticals?" The analyst believes inferior efficacy to Soliris should put "to bed" the treat from RA, and he reminds investors that ALXN1210 "should raise the bar from a convenience standpoint." The analyst sees "little reason to fret" at this point over the competitive threat to Alexion from RA101495. Raymond keeps an Overweight rating on Alexion with a $170 price target.
12/04/17
BMOC
12/04/17
NO CHANGE
Target $34
BMOC
Outperform
RA Pharmaceuticals price target raised to $34 from $31 at BMO Capital
12/04/17
12/04/17
NO CHANGE
Target $34

Outperform
RA Pharmaceuticals price target raised after trial success at BMO Capital
As previously reported, BMO Capital analyst M. IanSomaiya raised his price target for RA Pharmaceuticals to $34 from $31, while reiterating an Outperform rating, after its RA101495 demonstrated clinical benefit in all three cohorts in the ongoing Phase 2 paroxysmal nocturnal hemoglobinuria trial. The analyst believes phase 3 design is rational and likely to succeed.
12/04/17
JEFF
12/04/17
NO CHANGE
Target $25
JEFF
Buy
RA Pharmaceuticals selloff 'way too overdone,' says Jefferies
Jefferies analyst Eun Yang views the post-Phase 2 data selloff today in shares of RA Pharmaceuticals (RARX) as overreaction. The interim data show RA's RA101495 is an active and approvable product with efficacy as good as Alexion's (ALXN) Soliris, Yang tells investors in an intraday research note. While RA101495 may not be suitable for the 20% of Soliris patients that are transfusion dependent, the 37% selloff in the stock today is "way too overdone," the analyst contends. Yang sees "significant upside potential" in RA shares even at "modest market share of Soliris." She keeps a Buy rating on RA Pharmaceuticals with a $25 price target. The stock in midday trading is down $5.34 to $8.89.

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